Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling

• Published in: EMBO reports Vol. 22; no. 12; pp. e52170 - n/a
• Main Authors: Górska, Agnieszka A, Sandmann, Clara, Riechert, Eva, Hofmann, Christoph, Malovrh, Ellen, Varma, Eshita, Kmietczyk, Vivien, Ölschläger, Julie, Jürgensen, Lonny, Kamuf-Schenk, Verena, Stroh, Claudia, Furkel, Jennifer, Konstandin, Mathias H, Sticht, Carsten, Boileau, Etienne, Dieterich, Christoph, Frey, Norbert, Katus, Hugo A, Doroudgar, Shirin, Völkers, Mirko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.12.2021; Blackwell Publishing Ltd; John Wiley and Sons Inc
• Subjects: Cand2; cardiac; Cardiomyocytes; Coronary artery disease; Cullin; EMBO24; Gene deletion; Gene expression; Gene sequencing; Genes; Genomes; Heart diseases; Humans; Hypertrophy; Mechanistic Target of Rapamycin Complex 1 - genetics; Mechanistic Target of Rapamycin Complex 1 - metabolism; mTOR; Muscle Proteins; Muscles; Myocardium; Myocardium - metabolism; Myocyte enhancer factor 2; Myocytes; Myocytes, Cardiac - metabolism; Proteins; Rapamycin; Signal Transduction; TOR protein; Transcription Factors; Translation; Up-Regulation; Ventricular Remodeling - genetics; mTOR; Cand2; hypertrophy; cardiac

The mechanistic target of rapamycin (mTOR) promotes pathological remodeling in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in cardiomyocytes is protective; however, a detailed role of mTOR in translational regulation of specific mRNA networks in the diseased...