A Rapamycin-Sensitive Signaling Pathway Is Essential for the Full Expression of Persistent Pain States

• Published in: The Journal of neuroscience Vol. 29; no. 47; pp. 15017 - 15027
• Main Authors: Geranton, Sandrine M, Jimenez-Diaz, Lydia, Torsney, Carole, Tochiki, Keri K, Stuart, Sarah A, Leith, J. Lianne, Lumb, Bridget M, Hunt, Stephen P
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 25.11.2009; Society for Neuroscience
• Subjects: Afferent Pathways - cytology; Afferent Pathways - drug effects; Afferent Pathways - metabolism; Animals; Hyperalgesia - metabolism; Hyperalgesia - physiopathology; Immunosuppressive Agents - pharmacology; Male; Nerve Fibers, Myelinated - physiology; Nerve Fibers, Myelinated - ultrastructure; Nociceptors - cytology; Nociceptors - drug effects; Nociceptors - metabolism; Pain - metabolism; Pain - physiopathology; Pain Measurement; Pain Threshold - drug effects; Pain Threshold - physiology; Peripheral Nervous System Diseases - metabolism; Peripheral Nervous System Diseases - physiopathology; Posterior Horn Cells - cytology; Posterior Horn Cells - drug effects; Posterior Horn Cells - metabolism; Protein Kinases - metabolism; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sciatic Neuropathy - metabolism; Sciatic Neuropathy - physiopathology; Sirolimus - pharmacology; Spinal Nerve Roots - cytology; Spinal Nerve Roots - drug effects; Spinal Nerve Roots - metabolism; Spinothalamic Tracts - physiology; TOR Serine-Threonine Kinases

Translational control through the mammalian target of rapamycin (mTOR) is critical for synaptic plasticity, cell growth, and axon guidance. Recently, it was also shown that mTOR signaling was essential for the maintenance of the sensitivity of subsets of adult sensory neurons. Here, we show that per...