Evidence for N-methyl- d-aspartate and AMPA subtypes of the glutamate receptor on substantia nigra dopamine neurons: Possible preferential role for N-methyl- d-aspartate receptors

• Published in: Neuroscience Vol. 67; no. 2; pp. 373 - 381
• Main Authors: Christoffersen, C.L., Meltzer, L.T.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1995; Elsevier
• Subjects: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology; Animals; Biological and medical sciences; Central nervous system; Dopamine - physiology; Electrophysiology; Fundamental and applied biological sciences. Psychology; Glutamic Acid - administration & dosage; Glutamic Acid - pharmacology; Iontophoresis; Male; N-Methylaspartate - administration & dosage; N-Methylaspartate - pharmacology; Neurons - metabolism; Piperazines - pharmacology; Quinoxalines - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, AMPA - agonists; Receptors, AMPA - antagonists & inhibitors; Receptors, AMPA - metabolism; Receptors, N-Methyl-D-Aspartate - agonists; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; Substantia Nigra - cytology; Substantia Nigra - metabolism; Vertebrates: nervous system and sense organs; NMDA; CPP; AMPA; DA; NBQX; Rat; Rodentia; Central nervous system; Discharge pattern; Electrophysiology; Glutamate receptor; Glutamate; Vertebrata; AMPA receptor; Mammalia; Locus niger; Excitatory aminoacid; Neurotransmitter; Dopaminergic neuron; NMDA receptor; Brain (vertebrata)

The present studies utilized extracellular single-unit recordings in chloral hydrate-anesthetized rats to evaluate the contribution of N-methyl- d-aspartate (NMDA) and ( R,S)-α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtypes of glutamate receptors to the excitatory effects of glutamat...