A bias-ed assessment of the use of SNPs in human complex traits

• Published in: Current Opinion in Genetics & Development Vol. 12; no. 6; pp. 726 - 734
• Main Authors: Terwilliger, Joseph D., Haghighi, Fatemeh, Hiekkalinna, Tero S., Göring, Harald H.H.
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2002
• Subjects: Bias; Chromosome Mapping; genotype-phenotype relationship; haplotype maps; human genome project; Humans; linkage analysis; Linkage Disequilibrium; Multifactorial Inheritance; multiple testing bias; Polymorphism, Single Nucleotide; Research Design; small sample bias; SNP; multiple testing bias; SNP; linkage analysis; Techniques & Methods; haplotype maps; Genetics; small sample bias; genotype-phenotype relationship; human genome project; Bioinformatics; linkage disequilibrium

Although many biotechnological advancements have been made in the past decade, there has been very limited success in unraveling the genetic component of complex traits. Heavily invested research has been initiated based on etiological models of unrealistic simplicity and conducted under poor experi...