Akkermansia muciniphila supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses

• Published in: Gut microbes Vol. 15; no. 2; p. 2252764
• Main Authors: Li, Na, Tan, Shuwen, Wang, Yue, Deng, Jiao, Wang, Nan, Zhu, Shan, Tian, Wen, Xu, Jing, Wang, Qiang
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 18.12.2023; Taylor & Francis Group
• Subjects: Akkermansia muciniphila; cognitive dysfunction; microbiota-gut-brain axis; microglia; Research Paper; short chain fatty acids; Sleep deprivation; synapse

The microbiome-gut-brain axis plays a crucial role in many neurological diseases, including mild cognitive impairment. Sleep deprivation (SD) induces cognitive decline accompanied by alterations in the gut microbiota. However, the role of gut microbiota alterations in SD-induced cognitive dysfunctio...