SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

• Published in: Neoplasia (New York, N.Y.) Vol. 21; no. 7; pp. 665 - 675
• Main Authors: Chen, Shuaiyi, Yang, Xin, Yu, Miao, Wang, Zhe, Liu, Boya, Liu, Minghui, Liu, Lu, Ren, Mengmeng, Qi, Hao, Zou, Junhua, Vucenik, Ivana, Zhu, Wei-Guo, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier
• Subjects: Acetylation; Cell Proliferation - genetics; delta-1-Pyrroline-5-Carboxylate Reductase; Humans; MCF-7 Cells; Mitochondria - genetics; Mitochondria - metabolism; Neoplasms - genetics; Neoplasms - pathology; Peptide Fragments - genetics; Proline - biosynthesis; Proline - metabolism; Pyrroline Carboxylate Reductases - genetics; Sialoglycoproteins - genetics; Sirtuin 3 - genetics

SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported. Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to pro...