Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial

• Published in: The Lancet global health Vol. 5; no. 11; pp. e1080 - e1089
• Main Authors: Moh, Raoul, Gabillard, Delphine, Kabran, Mathieu, Ntakpé, Jean-Baptiste, Carrou, Jérôme Le, Kouame, Gérard M, Ouattara, Eric, Messou, Eugène, Anzian, Amani, Minga, Albert, Gouesse, Patrice, Rabe, Cyprien, Sidibé, Baba, Nzunetu, Gustave, Kouame, Amadou-Barenson, Kouamé, Emmanuel, Hawerlander, Denise, Ackoundzé, Simplice, Koule, Serge, Dembélé, Fassery, Koné, Fatoumata, Mbakop, Nathalie, Babatunde, Carolle, Babatunde, Nathaniel, Bleoué, Gisèle, Tchoutedjem, Mireille, Kouadio, Alain-Claude, Karcher, Sophie, Bakayoko, Alima, Aka, Kakou, N'Dri-Yoman, Thérèse, Ouassa, Timothée, Danel, Christine, Anglaret, Xavier, Badje, Anani, Guéhi, Calixte, Kouame, Gérard-Menan, Gnokoro, Joachim, Toni, Thomas-d'Aquin, Amon, Solange, Koua, Aboli, Daligou, Marcelle, Séri, Jonas, Ani, Alex, Sena, Ghislaine, Yededji, Sahinou-Yediga, Kouame, Abo, Domoua, Serge-K., Ahibo, Hughes, Ménan, Hervé, Inwoley, André, Ndja, Ben-Ahoussi, Adou, Blandine, Bissagnene, Emmanuel, Ba-Gomis, Olivier, Zike, Yves-Alain, Sassan-Morokro, Madeleine, Doféré, Bamba, Mesmin, Koman, Horo, Apollinaire, Oussou, Armel, N'Guessan, Kouamé, Jean, Kevin, Bohoussou, Franck, Yao-Yapi, Cyril, Aboua, Adrienne, Konan, Sylvie, Kouamé, Antoine, N'Chot, Celestin, Amani, Elvis, Clouet, Gwenaëlle, Girard, Pierre-Marie, Masumbuko, Jean-Marie, Perronne, Christian, Sow, Papa-Salif
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2017; Elsevier
• Subjects: Adult; Africa, Western - epidemiology; Anti-Retroviral Agents - therapeutic use; Antitubercular Agents - therapeutic use; CD4 Lymphocyte Count - statistics & numerical data; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections - drug therapy; HIV Infections - mortality; Humans; Isoniazid - therapeutic use; Life Sciences; Male; Risk; Santé publique et épidémiologie; Treatment Outcome

Temprano ANRS 12136 was a factorial 2 × 2 trial that assessed the benefits of early antiretroviral therapy (ART; ie, in patients who had not reached the CD4 cell count threshold used to recommend starting ART, as per the WHO guidelines that were the standard during the study period) and 6-month ison...