Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study

Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are un...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 12; no. 1; pp. 20130 - 9
Main Authors Kubo, Haremaru, Sawada, Shojiro, Satoh, Michihiro, Asai, Yoichiro, Kodama, Shinjiro, Sato, Toshihiro, Tomiyama, Seitaro, Seike, Junro, Takahashi, Kei, Kaneko, Keizo, Imai, Junta, Katagiri, Hideki
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.11.2022
Nature Portfolio
Subjects
692/163/2743/137
692/163/2743/2037
692/163/2743/2815
692/163/2743/393
Adult
Comorbidity
Humanities and Social Sciences
Humans
Insulin-Like Growth Factor I
Japan - epidemiology
Metabolic Diseases - complications
Metabolic Diseases - epidemiology
multidisciplinary
Obesity - complications
Obesity - epidemiology
Retrospective Studies
Science
Science (multidisciplinary)
Japan
Online AccessGet full text

Cover

Abstract Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are unknown. We examined 64 obese subjects with a body mass index (BMI) ≥ 35 kg/m 2 , with no history of endocrinological disorders, receiving inpatient care. IGF-1 levels were interpreted based on the IGF-1 standard deviation score (SDS) clinically used and standardized by age and sex (low IGF-1 group; ≤ − 2.0 SDS and standard IGF-1 group; − 2.0 < and <  + 2.0 SDS). Notably, 26.6% of the subjects had low IGF-1. Body fat mass and percentage, but not BMI, were significantly higher in the low than in the standard IGF-1 group. Furthermore, natural log-transformed high-sensitivity C-reactive protein, and the frequencies of dyslipidemia and hyperuricemia were higher in the low IGF-1 group. Moreover, among the subjects without diabetes, fasting glucose levels were significantly higher in the low IGF-1 group. Stepwise variable selection procedure revealed body fat percentage to be a parameter most strongly associated with low IGF-1. Thus, low IGF-1 levels may be an important marker of adiposity-associated metabolic disorders in obese patients.
AbstractList Abstract Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are unknown. We examined 64 obese subjects with a body mass index (BMI) ≥ 35 kg/m2, with no history of endocrinological disorders, receiving inpatient care. IGF-1 levels were interpreted based on the IGF-1 standard deviation score (SDS) clinically used and standardized by age and sex (low IGF-1 group; ≤ − 2.0 SDS and standard IGF-1 group; − 2.0 < and <  + 2.0 SDS). Notably, 26.6% of the subjects had low IGF-1. Body fat mass and percentage, but not BMI, were significantly higher in the low than in the standard IGF-1 group. Furthermore, natural log-transformed high-sensitivity C-reactive protein, and the frequencies of dyslipidemia and hyperuricemia were higher in the low IGF-1 group. Moreover, among the subjects without diabetes, fasting glucose levels were significantly higher in the low IGF-1 group. Stepwise variable selection procedure revealed body fat percentage to be a parameter most strongly associated with low IGF-1. Thus, low IGF-1 levels may be an important marker of adiposity-associated metabolic disorders in obese patients.
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are unknown. We examined 64 obese subjects with a body mass index (BMI) ≥ 35 kg/m2, with no history of endocrinological disorders, receiving inpatient care. IGF-1 levels were interpreted based on the IGF-1 standard deviation score (SDS) clinically used and standardized by age and sex (low IGF-1 group; ≤ - 2.0 SDS and standard IGF-1 group; - 2.0 < and <  + 2.0 SDS). Notably, 26.6% of the subjects had low IGF-1. Body fat mass and percentage, but not BMI, were significantly higher in the low than in the standard IGF-1 group. Furthermore, natural log-transformed high-sensitivity C-reactive protein, and the frequencies of dyslipidemia and hyperuricemia were higher in the low IGF-1 group. Moreover, among the subjects without diabetes, fasting glucose levels were significantly higher in the low IGF-1 group. Stepwise variable selection procedure revealed body fat percentage to be a parameter most strongly associated with low IGF-1. Thus, low IGF-1 levels may be an important marker of adiposity-associated metabolic disorders in obese patients.Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are unknown. We examined 64 obese subjects with a body mass index (BMI) ≥ 35 kg/m2, with no history of endocrinological disorders, receiving inpatient care. IGF-1 levels were interpreted based on the IGF-1 standard deviation score (SDS) clinically used and standardized by age and sex (low IGF-1 group; ≤ - 2.0 SDS and standard IGF-1 group; - 2.0 < and <  + 2.0 SDS). Notably, 26.6% of the subjects had low IGF-1. Body fat mass and percentage, but not BMI, were significantly higher in the low than in the standard IGF-1 group. Furthermore, natural log-transformed high-sensitivity C-reactive protein, and the frequencies of dyslipidemia and hyperuricemia were higher in the low IGF-1 group. Moreover, among the subjects without diabetes, fasting glucose levels were significantly higher in the low IGF-1 group. Stepwise variable selection procedure revealed body fat percentage to be a parameter most strongly associated with low IGF-1. Thus, low IGF-1 levels may be an important marker of adiposity-associated metabolic disorders in obese patients.
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are unknown. We examined 64 obese subjects with a body mass index (BMI) ≥ 35 kg/m 2 , with no history of endocrinological disorders, receiving inpatient care. IGF-1 levels were interpreted based on the IGF-1 standard deviation score (SDS) clinically used and standardized by age and sex (low IGF-1 group; ≤ − 2.0 SDS and standard IGF-1 group; − 2.0 < and <  + 2.0 SDS). Notably, 26.6% of the subjects had low IGF-1. Body fat mass and percentage, but not BMI, were significantly higher in the low than in the standard IGF-1 group. Furthermore, natural log-transformed high-sensitivity C-reactive protein, and the frequencies of dyslipidemia and hyperuricemia were higher in the low IGF-1 group. Moreover, among the subjects without diabetes, fasting glucose levels were significantly higher in the low IGF-1 group. Stepwise variable selection procedure revealed body fat percentage to be a parameter most strongly associated with low IGF-1. Thus, low IGF-1 levels may be an important marker of adiposity-associated metabolic disorders in obese patients.
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels. However, the prevalence and clinical characteristics of obese subjects with low IGF-1 levels are unknown. We examined 64 obese subjects with a body mass index (BMI) ≥ 35 kg/m , with no history of endocrinological disorders, receiving inpatient care. IGF-1 levels were interpreted based on the IGF-1 standard deviation score (SDS) clinically used and standardized by age and sex (low IGF-1 group; ≤ - 2.0 SDS and standard IGF-1 group; - 2.0 < and <  + 2.0 SDS). Notably, 26.6% of the subjects had low IGF-1. Body fat mass and percentage, but not BMI, were significantly higher in the low than in the standard IGF-1 group. Furthermore, natural log-transformed high-sensitivity C-reactive protein, and the frequencies of dyslipidemia and hyperuricemia were higher in the low IGF-1 group. Moreover, among the subjects without diabetes, fasting glucose levels were significantly higher in the low IGF-1 group. Stepwise variable selection procedure revealed body fat percentage to be a parameter most strongly associated with low IGF-1. Thus, low IGF-1 levels may be an important marker of adiposity-associated metabolic disorders in obese patients.
ArticleNumber 20130
Author Seike, Junro
Kaneko, Keizo
Kodama, Shinjiro
Sato, Toshihiro
Satoh, Michihiro
Tomiyama, Seitaro
Takahashi, Kei
Imai, Junta
Kubo, Haremaru
Sawada, Shojiro
Asai, Yoichiro
Katagiri, Hideki
Author_xml – sequence: 1
  givenname: Haremaru
  surname: Kubo
  fullname: Kubo, Haremaru
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 2
  givenname: Shojiro
  surname: Sawada
  fullname: Sawada, Shojiro
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital, Division of Metabolism and Diabetes, Faculty of Medicine, Tohoku Medical and Pharmaceutical University
– sequence: 3
  givenname: Michihiro
  surname: Satoh
  fullname: Satoh, Michihiro
  organization: Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University
– sequence: 4
  givenname: Yoichiro
  surname: Asai
  fullname: Asai, Yoichiro
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 5
  givenname: Shinjiro
  surname: Kodama
  fullname: Kodama, Shinjiro
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 6
  givenname: Toshihiro
  surname: Sato
  fullname: Sato, Toshihiro
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 7
  givenname: Seitaro
  surname: Tomiyama
  fullname: Tomiyama, Seitaro
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 8
  givenname: Junro
  surname: Seike
  fullname: Seike, Junro
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 9
  givenname: Kei
  surname: Takahashi
  fullname: Takahashi, Kei
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 10
  givenname: Keizo
  surname: Kaneko
  fullname: Kaneko, Keizo
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 11
  givenname: Junta
  surname: Imai
  fullname: Imai, Junta
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
– sequence: 12
  givenname: Hideki
  surname: Katagiri
  fullname: Katagiri, Hideki
  email: katagiri@med.tohoku.ac.jp
  organization: Department of Diabetes and Metabolism, Tohoku University Graduate School of Medicine, Tohoku University Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36418379$$D View this record in MEDLINE/PubMed
BookMark eNp9Uk1vEzEQXaEiWkr_AAfkIwcWbK-9H0JCQlULQZW49G75Y3bj4NjB9qbKv-Gn4iSlajnUF9vj996MZ97r6sQHD1X1luCPBDf9p8QIH_oaU1rThlNSkxfVGcWMlyulJ4_Op9VFSitcFqcDI8Or6rRpGembbjir_ix8mp31tbO_AE0x3OUlGqXOIdYEOdiCS0hGQDKloK3MYNCdLZilnZZIh3WIyhqbdyiMaA1ZquCsRsamEA3EhKxHQUEClGa1Ap3TZyTRD7mR_hC0fnJQa_AZ4gcUIceQNgVmt1CnPJvdm-rlKF2Ci_v9vLq9vrq9_F7f_Py2uPx6U2tOaK5Bg2RYNYNilGqJ25ZqRRQe2dhhyXsKlEjTUm463WoKvaHNgJWRnCkudXNeLY6yJsiV2ES7lnEngrTiEAhxEjJmqx0I05CW9RhM37UMU5BATNsr0nHVklJA0fpy1NrMag1m_7ko3RPRpy_eLsUUtmJoe8YpLwLv7wVi-D1DymJtkwbnStPCnATtmqFjrGGkQN89zvWQ5N-EC4AeAbp0NkUYHyAEi72TxNFJojhJHJwk9qr9fyRts8w27Ou17nlqc6SmksdPEMUqzNGX0T3H-gtFOOE1
CitedBy_id crossref_primary_10_1080_10408363_2024_2306804
crossref_primary_10_3390_ijms25073853
crossref_primary_10_1007_s00467_024_06330_8
crossref_primary_10_3390_ijms25063243
crossref_primary_10_1016_j_eurox_2024_100334
crossref_primary_10_3390_cancers15092440
crossref_primary_10_1111_dom_15695
crossref_primary_10_1186_s12889_024_18065_0
crossref_primary_10_3390_ijms24119556
crossref_primary_10_3390_antiox12051063
crossref_primary_10_3390_metabo14090489
crossref_primary_10_1172_jci_insight_160257
crossref_primary_10_1186_s12887_024_05118_x
crossref_primary_10_1210_jcemcr_luae114
crossref_primary_10_22141_2224_0721_20_6_2024_1440
crossref_primary_10_3390_cancers16030531
Cites_doi 10.1530/eje.1.01829
10.1016/j.atherosclerosis.2009.01.046
10.1016/j.molmet.2021.101245
10.1210/jcem.86.4.7377
10.1172/JCI117427
10.1056/NEJMra1817346
10.1038/nrendo.2018.22
10.1373/clinchem.2010.150631
10.1507/endocrj.ej12-0110
10.1016/S0140-6736(17)32129-3
10.1007/s13340-021-00562-x
10.1016/j.amjhyper.2006.05.010
10.1053/j.ajkd.2008.12.034
10.1016/j.ghir.2004.12.003
10.1016/0026-0495(94)90099-x
10.1038/s41440-019-0284-9
10.5551/jat.GL2017
10.1007/BF00280883
10.1093/gerona/glaa282
10.1016/j.beem.2015.07.002
10.1038/nrendo.2013.67
10.3390/jcm9082614
10.1038/s41387-022-00217-z
10.1016/j.ecl.2020.02.009
10.1210/clinem/dgaa792
10.1210/jcem.85.4.6541
10.1111/jdi.13306
10.1371/journal.pone.0121087
10.1002/j.1550-8528.1996.tb00256.x
10.1172/JCI92035
10.1530/EJE-10-0301
10.1507/endocrj.40.41
10.1210/jc.2014-2700
10.1016/j.ghir.2014.09.002
10.1038/nrendo.2013.64
10.4158/GL-2019-0405
10.3389/fmed.2021.683250
10.1016/s1096-6374(03)00038-8
10.5114/aoms.2016.58928
10.1186/s12967-015-0762-z
10.1159/000284355
10.1210/jc.2011-0179
10.1038/nrc1408
ContentType Journal Article
Copyright The Author(s) 2022
2022. The Author(s).
Copyright_xml – notice: The Author(s) 2022
– notice: 2022. The Author(s).
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOA
DOI 10.1038/s41598-022-23521-1
DatabaseName Springer Nature OA Free Journals (Freely Accessible)
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic


CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 9
ExternalDocumentID oai_doaj_org_article_d316480ed876402eae1d68b175b6139b
PMC9684525
36418379
10_1038_s41598_022_23521_1
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Japan
GeographicLocations_xml – name: Japan
GrantInformation_xml – fundername: Japan Society for the Promotion of Science
  grantid: 20H05694
  funderid: http://dx.doi.org/10.13039/501100001691
– fundername: Moonshot Research and Development Program
  grantid: JPMJPS2023
  funderid: http://dx.doi.org/10.13039/501100020963
– fundername: Japan Society for the Promotion of Science
  grantid: 20H05694
– fundername: Moonshot Research and Development Program
  grantid: JPMJPS2023
– fundername: ;
  grantid: 20H05694
– fundername: ;
  grantid: JPMJPS2023
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7X8
AARCD
PJZUB
PPXIY
PQGLB
5PM
PUEGO
ID FETCH-LOGICAL-c512t-ecea40b39b422ca0662cb1b0f4f70a582e21ad625d7c6c2e8d2390bda54b5ac3
IEDL.DBID DOA
ISSN 2045-2322
IngestDate Wed Aug 27 01:27:06 EDT 2025
Thu Aug 21 18:39:26 EDT 2025
Thu Aug 07 14:00:37 EDT 2025
Thu Jan 02 22:53:43 EST 2025
Thu Apr 24 23:08:40 EDT 2025
Tue Jul 01 00:55:28 EDT 2025
Fri Feb 21 02:36:47 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c512t-ecea40b39b422ca0662cb1b0f4f70a582e21ad625d7c6c2e8d2390bda54b5ac3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://doaj.org/article/d316480ed876402eae1d68b175b6139b
PMID 36418379
PQID 2739744341
PQPubID 23479
PageCount 9
ParticipantIDs doaj_primary_oai_doaj_org_article_d316480ed876402eae1d68b175b6139b
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9684525
proquest_miscellaneous_2739744341
pubmed_primary_36418379
crossref_primary_10_1038_s41598_022_23521_1
crossref_citationtrail_10_1038_s41598_022_23521_1
springer_journals_10_1038_s41598_022_23521_1
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-11-22
PublicationDateYYYYMMDD 2022-11-22
PublicationDate_xml – month: 11
  year: 2022
  text: 2022-11-22
  day: 22
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Portfolio
References Katznelson (CR9) 2014; 99
Juul (CR13) 2003; 13
Clemmons (CR38) 2011; 57
Matthews (CR42) 1985; 28
Isojima (CR11) 2012; 59
Sherlala (CR14) 2021; 76
Hoeflich, Russo (CR29) 2015; 29
Clayton (CR26) 2005; 152
Kinoshita (CR23) 2018; 25
Pena-Bello (CR16) 2015; 10
Yamanaka, Metabolism (CR22) 2012; 55
Saltiel, Olefsky (CR28) 2017; 127
Friedlander (CR32) 2001; 86
Hussain (CR31) 1994; 94
Juiz-Valiña (CR15) 2020
Hjelholt (CR18) 2020; 49
Umemura (CR21) 2019; 42
Savastano, Di Somma, Barrea, Colao (CR3) 2014; 24
Calle, Kaaks (CR17) 2004; 4
Ellulu, Patimah, Khaza'ai, Rahmat, Abed (CR27) 2017; 13
Lewitt (CR5) 2010; 163
Molitch (CR10) 2011; 96
Marques (CR39) 2021; 8
Junnila, List, Berryman, Murrey, Kopchick (CR7) 2013; 9
Matsuo (CR41) 2009; 53
Yamamoto, Kato (CR6) 1993; 40
Mauras, Haymond (CR33) 2005; 15
Yang, Björntorp, Liu, Edén (CR34) 1996; 4
Sasaki (CR19) 2022; 13
Berryman, Glad, List, Johannsson (CR35) 2013; 9
Mauras (CR30) 2000; 85
Araki (CR24) 2020; 11
LeRoith, Holly, Forbes (CR37) 2021; 52
Yuen (CR25) 2019; 25
Yanase (CR44) 2006; 19
Lee (CR20) 2022; 12
Ranke, Wit (CR8) 2018; 14
Aguirre, De Ita, de la Garza, Castilla-Cortazar (CR36) 2016; 14
Tokita (CR43) 2009; 206
Rasmussen (CR4) 1994; 43
Melmed (CR1) 2019; 380
Kreitschmann-Andermahr, Suarez, Jennings, Evers, Brabant (CR2) 2010; 73
(CR12) 2017; 390
Stanley (CR40) 2021; 106
A Hjelholt (23521_CR18) 2020; 49
S Melmed (23521_CR1) 2019; 380
RA Sherlala (23521_CR14) 2021; 76
T Yanase (23521_CR44) 2006; 19
S Umemura (23521_CR21) 2019; 42
TL Stanley (23521_CR40) 2021; 106
L Katznelson (23521_CR9) 2014; 99
P Juiz-Valiña (23521_CR15) 2020
S Savastano (23521_CR3) 2014; 24
MH Rasmussen (23521_CR4) 1994; 43
A Tokita (23521_CR43) 2009; 206
M Kinoshita (23521_CR23) 2018; 25
S Matsuo (23521_CR41) 2009; 53
DR Matthews (23521_CR42) 1985; 28
DE Berryman (23521_CR35) 2013; 9
DR Clemmons (23521_CR38) 2011; 57
MS Ellulu (23521_CR27) 2017; 13
L Pena-Bello (23521_CR16) 2015; 10
EE Calle (23521_CR17) 2004; 4
A Sasaki (23521_CR19) 2022; 13
MB Ranke (23521_CR8) 2018; 14
PE Clayton (23521_CR26) 2005; 152
N Mauras (23521_CR30) 2000; 85
H Yamanaka (23521_CR22) 2012; 55
KCJ Yuen (23521_CR25) 2019; 25
S Yang (23521_CR34) 1996; 4
AR Saltiel (23521_CR28) 2017; 127
T Isojima (23521_CR11) 2012; 59
A Hoeflich (23521_CR29) 2015; 29
I Kreitschmann-Andermahr (23521_CR2) 2010; 73
H Yamamoto (23521_CR6) 1993; 40
ME Molitch (23521_CR10) 2011; 96
H Lee (23521_CR20) 2022; 12
MS Lewitt (23521_CR5) 2010; 163
RK Junnila (23521_CR7) 2013; 9
GA Aguirre (23521_CR36) 2016; 14
MA Hussain (23521_CR31) 1994; 94
D LeRoith (23521_CR37) 2021; 52
E Araki (23521_CR24) 2020; 11
A Juul (23521_CR13) 2003; 13
V Marques (23521_CR39) 2021; 8
(NCD-RisC) NRFC (23521_CR12) 2017; 390
AL Friedlander (23521_CR32) 2001; 86
N Mauras (23521_CR33) 2005; 15
References_xml – volume: 152
  start-page: 165
  year: 2005
  end-page: 170
  ident: CR26
  article-title: Consensus statement on the management of the GH-treated adolescent in the transition to adult care
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/eje.1.01829
– volume: 206
  start-page: 168
  year: 2009
  end-page: 172
  ident: CR43
  article-title: Carotid arterial elasticity is a sensitive atherosclerosis value reflecting visceral fat accumulation in obese subjects
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2009.01.046
– volume: 52
  start-page: 101245
  year: 2021
  ident: CR37
  article-title: Insulin-like growth factors: Ligands, binding proteins and receptors
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2021.101245
– volume: 86
  start-page: 1496
  year: 2001
  end-page: 1503
  ident: CR32
  article-title: One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem.86.4.7377
– volume: 94
  start-page: 1126
  year: 1994
  end-page: 1133
  ident: CR31
  article-title: Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI117427
– volume: 380
  start-page: 2551
  year: 2019
  end-page: 2562
  ident: CR1
  article-title: Pathogenesis and diagnosis of growth hormone deficiency in adults
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra1817346
– volume: 14
  start-page: 285
  year: 2018
  end-page: 300
  ident: CR8
  article-title: Growth hormone—Past, present and future
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2018.22
– volume: 57
  start-page: 555
  year: 2011
  end-page: 559
  ident: CR38
  article-title: Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2010.150631
– volume: 59
  start-page: 771
  year: 2012
  end-page: 780
  ident: CR11
  article-title: Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method
  publication-title: Endocr. J.
  doi: 10.1507/endocrj.ej12-0110
– volume: 390
  start-page: 2627
  year: 2017
  end-page: 2642
  ident: CR12
  article-title: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)32129-3
– volume: 13
  start-page: 33
  year: 2022
  end-page: 34
  ident: CR19
  article-title: Correction to: Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: A joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society and the Japan Society for the Study of Obesity
  publication-title: Diabetol. Int.
  doi: 10.1007/s13340-021-00562-x
– volume: 19
  start-page: 1206
  year: 2006
  end-page: 1212
  ident: CR44
  article-title: Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope
  publication-title: Am. J. Hypertens.
  doi: 10.1016/j.amjhyper.2006.05.010
– volume: 53
  start-page: 982
  year: 2009
  end-page: 992
  ident: CR41
  article-title: Revised equations for estimated GFR from serum creatinine in Japan
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2008.12.034
– volume: 15
  start-page: 19
  year: 2005
  end-page: 27
  ident: CR33
  article-title: Are the metabolic effects of GH and IGF-I separable?
  publication-title: Growth Horm. IGF Res.
  doi: 10.1016/j.ghir.2004.12.003
– volume: 43
  start-page: 315
  year: 1994
  end-page: 319
  ident: CR4
  article-title: The impact of obesity, fat distribution and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin and growth hormone
  publication-title: Metabolism
  doi: 10.1016/0026-0495(94)90099-x
– volume: 42
  start-page: 1235
  year: 2019
  end-page: 1481
  ident: CR21
  article-title: The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2019)
  publication-title: Hypertens. Res.
  doi: 10.1038/s41440-019-0284-9
– volume: 25
  start-page: 846
  year: 2018
  end-page: 984
  ident: CR23
  article-title: Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017
  publication-title: J. Atheroscler. Thromb.
  doi: 10.5551/jat.GL2017
– volume: 28
  start-page: 412
  year: 1985
  end-page: 419
  ident: CR42
  article-title: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
– volume: 76
  start-page: 1303
  year: 2021
  end-page: 1308
  ident: CR14
  article-title: Relationship between serum IGF-1 and BMI differs by age
  publication-title: J. Gerontol. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glaa282
– volume: 29
  start-page: 685
  year: 2015
  end-page: 700
  ident: CR29
  article-title: Physiology and pathophysiology of IGFBP-1 and IGFBP-2—Consensus and dissent on metabolic control and malignant potential
  publication-title: Best Pract. Res. Clin. Endocrinol. Metab.
  doi: 10.1016/j.beem.2015.07.002
– volume: 9
  start-page: 366
  year: 2013
  end-page: 376
  ident: CR7
  article-title: The GH/IGF-1 axis in ageing and longevity
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2013.67
– year: 2020
  ident: CR15
  article-title: Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation
  publication-title: J. Clin. Med.
  doi: 10.3390/jcm9082614
– volume: 12
  start-page: 38
  year: 2022
  ident: CR20
  article-title: Effects of mild obesity on outcomes in Japanese patients with COVID-19: A nationwide consortium to investigate COVID-19 host genetics
  publication-title: Nutr. Diabetes
  doi: 10.1038/s41387-022-00217-z
– volume: 49
  start-page: 239
  year: 2020
  end-page: 250
  ident: CR18
  article-title: Growth hormone and obesity
  publication-title: Endocrinol. Metab. Clin. N. Am.
  doi: 10.1016/j.ecl.2020.02.009
– volume: 106
  start-page: e520
  year: 2021
  end-page: e533
  ident: CR40
  article-title: Relationship of IGF-1 and IGF-binding proteins to disease severity and glycemia in nonalcoholic fatty liver disease
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/clinem/dgaa792
– volume: 85
  start-page: 1686
  year: 2000
  end-page: 1694
  ident: CR30
  article-title: Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: Differential effects on protein, glucose, lipid and calcium metabolism
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem.85.4.6541
– volume: 55
  start-page: 324
  year: 2012
  end-page: 329
  ident: CR22
  article-title: Essence of the revised guideline for the management of hyperuricemia and gout
  publication-title: Jpn. Med. Assoc. J.
– volume: 11
  start-page: 1020
  year: 2020
  end-page: 1076
  ident: CR24
  article-title: Japanese clinical practice guideline for diabetes 2019
  publication-title: J. Diabetes Investig.
  doi: 10.1111/jdi.13306
– volume: 10
  start-page: e0121087
  year: 2015
  ident: CR16
  article-title: Effect of oral glucose administration on rebound growth hormone release in normal and obese women: The role of adiposity, insulin sensitivity and ghrelin
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0121087
– volume: 4
  start-page: 471
  year: 1996
  end-page: 478
  ident: CR34
  article-title: Growth hormone treatment of hypophysectomized rats increases catecholamine-induced lipolysis and the number of beta-adrenergic receptors in adipocytes: No differences in the effects of growth hormone on different fat depots
  publication-title: Obes. Res.
  doi: 10.1002/j.1550-8528.1996.tb00256.x
– volume: 127
  start-page: 1
  year: 2017
  end-page: 4
  ident: CR28
  article-title: Inflammatory mechanisms linking obesity and metabolic disease
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI92035
– volume: 163
  start-page: 233
  year: 2010
  end-page: 242
  ident: CR5
  article-title: IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/EJE-10-0301
– volume: 40
  start-page: 41
  year: 1993
  end-page: 45
  ident: CR6
  article-title: Relationship between plasma insulin-like growth factor I (IGF-I) levels and body mass index (BMI) in adults
  publication-title: Endocr. J.
  doi: 10.1507/endocrj.40.41
– volume: 99
  start-page: 3933
  year: 2014
  end-page: 3951
  ident: CR9
  article-title: Acromegaly: An endocrine society clinical practice guideline
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2014-2700
– volume: 24
  start-page: 221
  year: 2014
  end-page: 226
  ident: CR3
  article-title: The complex relationship between obesity and the somatropic axis: The long and winding road
  publication-title: Growth Horm. IGF Res.
  doi: 10.1016/j.ghir.2014.09.002
– volume: 9
  start-page: 346
  year: 2013
  end-page: 356
  ident: CR35
  article-title: The GH/IGF-1 axis in obesity: Pathophysiology and therapeutic considerations
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2013.64
– volume: 25
  start-page: 1191
  year: 2019
  end-page: 1232
  ident: CR25
  article-title: American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care
  publication-title: Endocr. Pract.
  doi: 10.4158/GL-2019-0405
– volume: 8
  start-page: 683250
  year: 2021
  ident: CR39
  article-title: Adiponectin, leptin and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD
  publication-title: Front. Med.
  doi: 10.3389/fmed.2021.683250
– volume: 13
  start-page: 113
  year: 2003
  end-page: 170
  ident: CR13
  article-title: Serum levels of insulin-like growth factor I and its binding proteins in health and disease
  publication-title: Growth Horm. IGF Res.
  doi: 10.1016/s1096-6374(03)00038-8
– volume: 13
  start-page: 851
  year: 2017
  end-page: 863
  ident: CR27
  article-title: Obesity and inflammation: The linking mechanism and the complications
  publication-title: Arch. Med. Sci.
  doi: 10.5114/aoms.2016.58928
– volume: 14
  start-page: 3
  year: 2016
  ident: CR36
  article-title: Insulin-like growth factor-1 deficiency and metabolic syndrome
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-015-0762-z
– volume: 73
  start-page: 153
  year: 2010
  end-page: 160
  ident: CR2
  article-title: GH/IGF-I regulation in obesity–mechanisms and practical consequences in children and adults
  publication-title: Horm. Res. Paediatr.
  doi: 10.1159/000284355
– volume: 96
  start-page: 1587
  year: 2011
  end-page: 1609
  ident: CR10
  article-title: Evaluation and treatment of adult growth hormone deficiency: An Endocrine Society clinical practice guideline
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2011-0179
– volume: 4
  start-page: 579
  year: 2004
  end-page: 591
  ident: CR17
  article-title: Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1408
– volume: 390
  start-page: 2627
  year: 2017
  ident: 23521_CR12
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)32129-3
– volume: 14
  start-page: 3
  year: 2016
  ident: 23521_CR36
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-015-0762-z
– volume: 152
  start-page: 165
  year: 2005
  ident: 23521_CR26
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/eje.1.01829
– volume: 8
  start-page: 683250
  year: 2021
  ident: 23521_CR39
  publication-title: Front. Med.
  doi: 10.3389/fmed.2021.683250
– volume: 163
  start-page: 233
  year: 2010
  ident: 23521_CR5
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/EJE-10-0301
– volume: 96
  start-page: 1587
  year: 2011
  ident: 23521_CR10
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2011-0179
– volume: 106
  start-page: e520
  year: 2021
  ident: 23521_CR40
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/clinem/dgaa792
– volume: 52
  start-page: 101245
  year: 2021
  ident: 23521_CR37
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2021.101245
– volume: 43
  start-page: 315
  year: 1994
  ident: 23521_CR4
  publication-title: Metabolism
  doi: 10.1016/0026-0495(94)90099-x
– volume: 14
  start-page: 285
  year: 2018
  ident: 23521_CR8
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2018.22
– year: 2020
  ident: 23521_CR15
  publication-title: J. Clin. Med.
  doi: 10.3390/jcm9082614
– volume: 9
  start-page: 346
  year: 2013
  ident: 23521_CR35
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2013.64
– volume: 11
  start-page: 1020
  year: 2020
  ident: 23521_CR24
  publication-title: J. Diabetes Investig.
  doi: 10.1111/jdi.13306
– volume: 15
  start-page: 19
  year: 2005
  ident: 23521_CR33
  publication-title: Growth Horm. IGF Res.
  doi: 10.1016/j.ghir.2004.12.003
– volume: 59
  start-page: 771
  year: 2012
  ident: 23521_CR11
  publication-title: Endocr. J.
  doi: 10.1507/endocrj.ej12-0110
– volume: 49
  start-page: 239
  year: 2020
  ident: 23521_CR18
  publication-title: Endocrinol. Metab. Clin. N. Am.
  doi: 10.1016/j.ecl.2020.02.009
– volume: 9
  start-page: 366
  year: 2013
  ident: 23521_CR7
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2013.67
– volume: 42
  start-page: 1235
  year: 2019
  ident: 23521_CR21
  publication-title: Hypertens. Res.
  doi: 10.1038/s41440-019-0284-9
– volume: 85
  start-page: 1686
  year: 2000
  ident: 23521_CR30
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem.85.4.6541
– volume: 25
  start-page: 1191
  year: 2019
  ident: 23521_CR25
  publication-title: Endocr. Pract.
  doi: 10.4158/GL-2019-0405
– volume: 4
  start-page: 579
  year: 2004
  ident: 23521_CR17
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1408
– volume: 12
  start-page: 38
  year: 2022
  ident: 23521_CR20
  publication-title: Nutr. Diabetes
  doi: 10.1038/s41387-022-00217-z
– volume: 99
  start-page: 3933
  year: 2014
  ident: 23521_CR9
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2014-2700
– volume: 53
  start-page: 982
  year: 2009
  ident: 23521_CR41
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2008.12.034
– volume: 13
  start-page: 33
  year: 2022
  ident: 23521_CR19
  publication-title: Diabetol. Int.
  doi: 10.1007/s13340-021-00562-x
– volume: 10
  start-page: e0121087
  year: 2015
  ident: 23521_CR16
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0121087
– volume: 29
  start-page: 685
  year: 2015
  ident: 23521_CR29
  publication-title: Best Pract. Res. Clin. Endocrinol. Metab.
  doi: 10.1016/j.beem.2015.07.002
– volume: 73
  start-page: 153
  year: 2010
  ident: 23521_CR2
  publication-title: Horm. Res. Paediatr.
  doi: 10.1159/000284355
– volume: 127
  start-page: 1
  year: 2017
  ident: 23521_CR28
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI92035
– volume: 4
  start-page: 471
  year: 1996
  ident: 23521_CR34
  publication-title: Obes. Res.
  doi: 10.1002/j.1550-8528.1996.tb00256.x
– volume: 19
  start-page: 1206
  year: 2006
  ident: 23521_CR44
  publication-title: Am. J. Hypertens.
  doi: 10.1016/j.amjhyper.2006.05.010
– volume: 380
  start-page: 2551
  year: 2019
  ident: 23521_CR1
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra1817346
– volume: 13
  start-page: 113
  year: 2003
  ident: 23521_CR13
  publication-title: Growth Horm. IGF Res.
  doi: 10.1016/s1096-6374(03)00038-8
– volume: 206
  start-page: 168
  year: 2009
  ident: 23521_CR43
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2009.01.046
– volume: 94
  start-page: 1126
  year: 1994
  ident: 23521_CR31
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI117427
– volume: 40
  start-page: 41
  year: 1993
  ident: 23521_CR6
  publication-title: Endocr. J.
  doi: 10.1507/endocrj.40.41
– volume: 76
  start-page: 1303
  year: 2021
  ident: 23521_CR14
  publication-title: J. Gerontol. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glaa282
– volume: 86
  start-page: 1496
  year: 2001
  ident: 23521_CR32
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem.86.4.7377
– volume: 25
  start-page: 846
  year: 2018
  ident: 23521_CR23
  publication-title: J. Atheroscler. Thromb.
  doi: 10.5551/jat.GL2017
– volume: 13
  start-page: 851
  year: 2017
  ident: 23521_CR27
  publication-title: Arch. Med. Sci.
  doi: 10.5114/aoms.2016.58928
– volume: 24
  start-page: 221
  year: 2014
  ident: 23521_CR3
  publication-title: Growth Horm. IGF Res.
  doi: 10.1016/j.ghir.2014.09.002
– volume: 57
  start-page: 555
  year: 2011
  ident: 23521_CR38
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2010.150631
– volume: 28
  start-page: 412
  year: 1985
  ident: 23521_CR42
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
– volume: 55
  start-page: 324
  year: 2012
  ident: 23521_CR22
  publication-title: Jpn. Med. Assoc. J.
SSID ssj0000529419
Score 2.4675043
Snippet Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly...
Abstract Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 20130
SubjectTerms 692/163/2743/137
692/163/2743/2037
692/163/2743/2815
692/163/2743/393
Adult
Comorbidity
Humanities and Social Sciences
Humans
Insulin-Like Growth Factor I
Japan - epidemiology
Metabolic Diseases - complications
Metabolic Diseases - epidemiology
multidisciplinary
Obesity - complications
Obesity - epidemiology
Retrospective Studies
Science
Science (multidisciplinary)
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LbtUwELWqIiQ2qLxTHjISO2qwHSeOhRACRFUqlVUrdWf5lTZqSCDJlejf8KmM87jShauu2OahxJkzmTO25wxCr1iZy9IFQ0pALxFSGgJxnhJnpVLGFq4ca6tOvuVHZ-L4PDvfQUu7o_kD9ltTu9hP6qyr3_z6ef0BHP79VDJevO0hCMVCMUirOPAJRiAbugWRSUZHPZnp_qT1zZVgaq6d2X7rRnwaZfy3cc9_t1D-tY46hqfDPXR35pX44wSEe2gnNPfR7anT5PUD9PvrtOec1NVVwBeQew-XeOq1Qxiu486hHpsuYDObK3gcp2hxlDPGgMq2s5UHxo7bEn8PA0Cnrhz2s3Znj6sGtzb0AfcrG6d2-nfY4GOIxM14EN65DiQOI3QHuAtD1y41nmRUuH2ITg-_nH4-InNzBuKAIwwkgIEFtamygnNnopC8s8zSUpSSmqzggTPjIbvy0uWOh8LzVFHrTSZsZlz6CO02bROeIMypT421RRYkFakRABCqUu9FYSi1ZZYgtlhEu1m4PPbPqPW4gJ4WerKiBivq0YqaJej1-p4fk2zHjVd_ioZeXxklt8cDbXehZw_WPoXMsqDBQ_yApDuYwHxeWKBfFiiRsgl6ucBEg4vGdRf4xO2q18AQIWsTwBcS9HiCzfpRaS7gpypVguQGoDbeZfNMU12OMuAqL-KidIIOFujpxX1uGOv-_xjrU3SHR59hjHD-DO0O3So8B3I22Bejx_0BC6w4eA
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals (Freely Accessible)
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bi9UwEA7LiuCLeLfeiOCbG8ytbYpPenBZF_RphX0LuXW3WFtpex723-xPdZK2B44uC76mKU06k8w3mZkvCL1jdVHWLhhSg_YSWZaGgJ2nxNmyqoxVrk61Vd--Fyc_5Ol5fn6A-FoLk5L2E6Vl2qbX7LAPIxiaWAwGrhMHzMAIeDx3InV71OpNsdmdq8TIlWTVUh9Dhbrh1T0blKj6b8KX_6ZJ_hUrTSbo-AG6v2BH_Gke7UN0ELpH6O58m-TVY3T9dc4rJ23zM-AL8K-nSzzfp0MYbmN20IjNELBZRBI8jsewOFIWY_gP_WAbD6gc9zX-FSZQj7Zx2C_8nCNuOtzbMAY8bm08vhk_YoNPwdp2qRHG3AYSpxGGIzyEaejXOk6SWGyfoLPjL2ebE7JcwEAc4ICJBBCipFZUVnLuTCSLd5ZZWsu6pCZXPHBmPHhQvnSF40F5LipqvcmlzY0TT9Fh13fhOcKcemGsVXkoqRRGghLQSngvlaHU1nmG2CoR7RZy8nhHRqtTkFwoPUtRgxR1kqJmGXq_e-f3TM1xa-_PUdC7npFWOzX0w4Ve1Ex7Ad6josGDjQDHOpjAfKEsQCwLsKeyGXq7qomGZRhjK_CL--2oAQWCZyYBE2To2aw2u0-JQsLGWVYZKvcUam8s-0-65jJRfVeFioHnDB2tqqeXPWa8Za4v_q_7S3SPx9XBGOH8FTqchm14DVBrsm_S2voDwpEmYQ
  priority: 102
  providerName: Springer Nature
Title Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study
URI https://link.springer.com/article/10.1038/s41598-022-23521-1
https://www.ncbi.nlm.nih.gov/pubmed/36418379
https://www.proquest.com/docview/2739744341
https://pubmed.ncbi.nlm.nih.gov/PMC9684525
https://doaj.org/article/d316480ed876402eae1d68b175b6139b
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1db9MwFLVgCIkXxDcZUBmJN2bNdpzYEU9dtWlU2oRgSH2z_JWtoiRTkj7wb_ipXCdptQIaL7w0kpOotu-x77mxfS5C71iZy9IFQ0pALxFSGgJ-nhJnZVEYq1zZn606O89Pv4r5IlvcSPUV94QN8sBDxx36FAi9osHDsIVYJ5jAfK4seD0LnqiwcfYFn3cjmBpUvXkhWDGekqGpOmzBU8XTZBB7cSAdjLAdT9QL9v-NZf65WfK3FdPeEZ08Qg9HBomnQ80fozuheoLuDzklfzxFPz8Ou8vJavkt4EuIsrsrPGTVIQyv4h6hFpsmYDMaJngcP8biKFyMAX91Y5ceuDmuS_w9dACS1dJhP6p0tnhZ4dqGNuB2beNHnPYDNngOPrfqC6HOq0BiM0JzgJvQNfXmNCfptWyfoYuT44vZKRnTMBAHbKAjAUwpqIW-Fpw7EyXjnWWWlqKU1GSKB86MhzjKS5c7HpTnaUGtN5mwmXHpc7RX1VV4iTCnPjXWqixIKlIjAAq0SL0XylBqyyxBbGMR7UaJ8pgpY6X7pfJU6cGKGqyoeytqlqD323euB4GOW58-iobePhnFtfsCgJweIaf_BbkEvd3ARMNgjCss0MX1utXABSE-E8AMEvRigM32r9JcwPQpiwTJHUDt1GX3TrW86gW_i1zF5ecEHWygp8eZpr2lrfv_o62v0AMexwxjhPPXaK9r1uEN0LDOTtBduZATdG86nX-Zw_Xo-PzTZyid5bNJPxrh90yoXxQCNkA
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaqIgQXxJuUl5G4UQu_8hInWFFtS9vTIvVm-ZU2YkmqJHvg3_BTGTvJSgtVJa6Oo9iZsecbz8xnhN6zKssr6zWpQHuJzHNNwM5TYk1eltoUtoq1VWfn2fK7PLlIL_YQn2thYtJ-pLSM2_ScHfaxB0MTisHAdeKAGRgBj-cOYO0spHEtssX2XCVEriQrp_oYKoobXt2xQZGq_yZ8-W-a5F-x0miCjh6iBxN2xJ_H0T5Ce755jO6Ot0n-eoJ-H4955WRd__D4Evzr4QqP9-kQhtchO6jHuvNYTyLxDodjWBwoizH8h7YztQNUjtsK__QDqMe6tthN_Jw9rhvcGt973G9MOL7pP2GNT8DaNrERxrz2JEzDd4e480PXznWcJLLYPkWro6-rxZJMFzAQCzhgIB6EKKkRpZGcWx3I4q1hhlayyqlOC-450w48KJfbzHJfOC5KapxOpUm1Fc_QftM2_gXCnDqhjSlSn1MptAQloKVwThaaUlOlCWKzRJSdyMnDHRlrFYPkolCjFBVIUUUpKpagD9t3rkdqjlt7fwmC3vYMtNqxoe0u1aRmygnwHgvqHdgIcKy99sxlhQGIZQD2lCZB72Y1UbAMQ2wFfnG76RWgQPDMJGCCBD0f1Wb7KZFJ2DjzMkH5jkLtjGX3SVNfRarvMitC4DlBh7PqqWmP6W-Z68H_dX-L7i1XZ6fq9Pj820t0n4eVwhjh_BXaH7qNfw2wazBv4jr7A8LsKVA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKEYgL4tmGp5G4UQvbcRJHnGBh1RaoOBSpN8uvtFGXBCXZA_-Gn8rYSVZaqCpxdRzFzow933hmPiP0mlV5UVmvSQXaS0RRaAJ2nhJrirLURtoq1lZ9PckPv4vjs-xsB-VzLUxM2o-UlnGbnrPD3vZgaEIxGLhOHDADI7DDuOoGugl4mwana5EvNmcrIXolWDnVyNBUXvH6lh2KdP1XYcx_UyX_ipdGM7S8h-5O-BG_H0d8H-345gG6Nd4o-esh-n005paTVX3p8Tn42MMFHu_UIQyvQoZQj3XnsZ7E4h0OR7E40BZj-BdtZ2oHyBy3Ff7hB1CRVW2xmzg6e1w3uDW-97hfm3CE07_DGh-DxW1iI4x55UmYhu8OcOeHrp1rOUlksn2ETpefTheHZLqEgVjAAgPxIEhBTVoawbnVgTDeGmZoJaqC6kxyz5l24EW5wuaWe-l4WlLjdCZMpm36GO02beP3EebUpdoYmfmCilQLUARaps4JqSk1VZYgNktE2YmgPNyTsVIxUJ5KNUpRgRRVlKJiCXqzeefnSM9xbe8PQdCbnoFaOza03bmaVE25FDxISb0DOwHOtdeeuVwagFkGoE9pEvRqVhMFSzHEV-AXt-teARIE70wALkjQ3qg2m0-luYDNsygTVGwp1NZYtp809UWk-y5zGYLPCTqYVU9N-0x_zVyf_F_3l-j2t49L9eXo5PNTdIeHhcIY4fwZ2h26tX8OyGswL-Iy-wPdwipZ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Insulin-like+growth+factor-1+levels+are+associated+with+high+comorbidity+of+metabolic+disorders+in+obese+subjects%3B+a+Japanese+single-center%2C+retrospective-study&rft.jtitle=Scientific+reports&rft.au=Haremaru+Kubo&rft.au=Shojiro+Sawada&rft.au=Michihiro+Satoh&rft.au=Yoichiro+Asai&rft.date=2022-11-22&rft.pub=Nature+Portfolio&rft.eissn=2045-2322&rft.volume=12&rft.issue=1&rft.spage=1&rft.epage=9&rft_id=info:doi/10.1038%2Fs41598-022-23521-1&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_d316480ed876402eae1d68b175b6139b
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon