Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism

• Published in: Scientific reports Vol. 10; no. 1; p. 17649
• Main Authors: O’Leary, Brianne R., Alexander, Matthew S., Du, Juan, Moose, Devon L., Henry, Michael D., Cullen, Joseph J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.10.2020
• Subjects: 631/67; 692/308; 692/4028; Animals; Antineoplastic Agents - therapeutic use; Ascorbic Acid - therapeutic use; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Female; Humanities and Social Sciences; Humans; Hydrogen Peroxide - metabolism; Liver Neoplasms - secondary; Mice; Mice, Nude; multidisciplinary; Neoplasm Metastasis - drug therapy; Neoplasm Transplantation; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - metabolism; Neoplasms, Experimental - pathology; Neoplastic Cells, Circulating - drug effects; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Peroxides - metabolism; Science; Science (multidisciplinary)

Pharmacological ascorbate (P-AscH − , high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer (PDAC) utilizing P-AscH − have demonstrated increases in progression free survival, suggesting a reduction in metastatic disease bur...