Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism - O’Leary, Brianne R.; Alexander, Matthew S.; Du, Juan; Moose, Devon L.; Henry, Michael D.; Cullen, Joseph J. (Scientific reports, 2020)
Keywords: 631/67; 692/308; 692/4028; Animals; Antineoplastic Agents - therapeutic use; Ascorbic Acid - therapeutic use; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Female; Humanities and Social Sciences; Humans; Hydrogen Peroxide - metabolism; Liver Neoplasms - secondary; Mice; Mice, Nude; multidisciplinary; Neoplasm Metastasis - drug therapy; Neoplasm Transplantation; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - metabolism; Neoplasms, Experimental - pathology; Neoplastic Cells, Circulating - drug effects; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Peroxides - metabolism; Science; Science (multidisciplinary)