Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

• Published in: Nature communications Vol. 7; no. 1; p. 13353
• Main Authors: Teh, Charis E., Lalaoui, Najoua, Jain, Reema, Policheni, Antonia N., Heinlein, Melanie, Alvarez-Diaz, Silvia, Sheridan, Julie M., Rieser, Eva, Deuser, Stefanie, Darding, Maurice, Koay, Hui-Fern, Hu, Yifang, Kupresanin, Fiona, O’Reilly, Lorraine A., Godfrey, Dale I., Smyth, Gordon K., Bouillet, Philippe, Strasser, Andreas, Walczak, Henning, Silke, John, Gray, Daniel H. D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.11.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 13/31; 13/95; 38/91; 631/250/1619/554/1898/1271; 631/250/2152/1566/2493; 631/250/516/1909; 64/110; 82/80; 96/34; Animals; Apoptosis; Base Sequence; Cell Differentiation - physiology; Cells; Cells, Cultured; Chemokines; Computational Biology; Cytokines; Dermatitis; Gene Expression Regulation - physiology; Genotype; Homeostasis; Homeostasis - physiology; Humanities and Social Sciences; Lymphocytes; Mice; multidisciplinary; Protein Multimerization; Protein Processing, Post-Translational; RNA - genetics; Science; Science (multidisciplinary); Sequence Analysis, RNA; T-Lymphocytes - classification; T-Lymphocytes - physiology; Thymus Gland - cytology; Tumor necrosis factor-TNF; Ubiquitin - chemistry; Ubiquitin - metabolism; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Australia

The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3 + regulatory T (Treg)-c...