Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3 + regulatory T (Treg)-c...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 7; no. 1; p. 13353
Main Authors Teh, Charis E., Lalaoui, Najoua, Jain, Reema, Policheni, Antonia N., Heinlein, Melanie, Alvarez-Diaz, Silvia, Sheridan, Julie M., Rieser, Eva, Deuser, Stefanie, Darding, Maurice, Koay, Hui-Fern, Hu, Yifang, Kupresanin, Fiona, O’Reilly, Lorraine A., Godfrey, Dale I., Smyth, Gordon K., Bouillet, Philippe, Strasser, Andreas, Walczak, Henning, Silke, John, Gray, Daniel H. D.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 18.11.2016
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/106
13/31
13/95
38/91
631/250/1619/554/1898/1271
631/250/2152/1566/2493
631/250/516/1909
64/110
82/80
96/34
Animals
Apoptosis
Base Sequence
Cell Differentiation - physiology
Cells
Cells, Cultured
Chemokines
Computational Biology
Cytokines
Dermatitis
Gene Expression Regulation - physiology
Genotype
Homeostasis
Homeostasis - physiology
Humanities and Social Sciences
Lymphocytes
Mice
multidisciplinary
Protein Multimerization
Protein Processing, Post-Translational
RNA - genetics
Science
Science (multidisciplinary)
Sequence Analysis, RNA
T-Lymphocytes - classification
T-Lymphocytes - physiology
Thymus Gland - cytology
Tumor necrosis factor-TNF
Ubiquitin - chemistry
Ubiquitin - metabolism
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
Australia
Online AccessGet full text

Cover

Abstract The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3 + regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation. LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.
AbstractList LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3 regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation.
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3+ regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation.
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3 + regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation. LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.
ArticleNumber 13353
Author Strasser, Andreas
Darding, Maurice
Bouillet, Philippe
Hu, Yifang
Koay, Hui-Fern
Smyth, Gordon K.
Sheridan, Julie M.
Rieser, Eva
O’Reilly, Lorraine A.
Godfrey, Dale I.
Kupresanin, Fiona
Gray, Daniel H. D.
Heinlein, Melanie
Jain, Reema
Deuser, Stefanie
Walczak, Henning
Teh, Charis E.
Policheni, Antonia N.
Lalaoui, Najoua
Silke, John
Alvarez-Diaz, Silvia
Author_xml – sequence: 1
  givenname: Charis E.
  surname: Teh
  fullname: Teh, Charis E.
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 2
  givenname: Najoua
  orcidid: 0000-0002-0165-3324
  surname: Lalaoui
  fullname: Lalaoui, Najoua
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 3
  givenname: Reema
  surname: Jain
  fullname: Jain, Reema
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 4
  givenname: Antonia N.
  surname: Policheni
  fullname: Policheni, Antonia N.
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 5
  givenname: Melanie
  surname: Heinlein
  fullname: Heinlein, Melanie
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 6
  givenname: Silvia
  surname: Alvarez-Diaz
  fullname: Alvarez-Diaz, Silvia
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 7
  givenname: Julie M.
  surname: Sheridan
  fullname: Sheridan, Julie M.
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 8
  givenname: Eva
  surname: Rieser
  fullname: Rieser, Eva
  organization: Centre for Cell Death, Cancer and Inflammation, University College London
– sequence: 9
  givenname: Stefanie
  surname: Deuser
  fullname: Deuser, Stefanie
  organization: Centre for Cell Death, Cancer and Inflammation, University College London
– sequence: 10
  givenname: Maurice
  surname: Darding
  fullname: Darding, Maurice
  organization: Centre for Cell Death, Cancer and Inflammation, University College London
– sequence: 11
  givenname: Hui-Fern
  surname: Koay
  fullname: Koay, Hui-Fern
  organization: The Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, The Australian Research Council Centre of Excellence for Advanced Molecular Imaging, The University of Melbourne
– sequence: 12
  givenname: Yifang
  surname: Hu
  fullname: Hu, Yifang
  organization: The Walter and Eliza Hall Institute of Medical Research
– sequence: 13
  givenname: Fiona
  surname: Kupresanin
  fullname: Kupresanin, Fiona
  organization: The Walter and Eliza Hall Institute of Medical Research, Present address: ANZAC Research Institute, Concord Repatriation General Hospital, Concord, New South Wales 2139, Australia
– sequence: 14
  givenname: Lorraine A.
  surname: O’Reilly
  fullname: O’Reilly, Lorraine A.
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 15
  givenname: Dale I.
  orcidid: 0000-0002-3009-5472
  surname: Godfrey
  fullname: Godfrey, Dale I.
  organization: The Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, The Australian Research Council Centre of Excellence for Advanced Molecular Imaging, The University of Melbourne
– sequence: 16
  givenname: Gordon K.
  orcidid: 0000-0001-9221-2892
  surname: Smyth
  fullname: Smyth, Gordon K.
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Mathematics and Statistics, The University of Melbourne
– sequence: 17
  givenname: Philippe
  surname: Bouillet
  fullname: Bouillet, Philippe
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 18
  givenname: Andreas
  surname: Strasser
  fullname: Strasser, Andreas
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 19
  givenname: Henning
  surname: Walczak
  fullname: Walczak, Henning
  organization: Centre for Cell Death, Cancer and Inflammation, University College London
– sequence: 20
  givenname: John
  orcidid: 0000-0002-7611-5774
  surname: Silke
  fullname: Silke, John
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
– sequence: 21
  givenname: Daniel H. D.
  surname: Gray
  fullname: Gray, Daniel H. D.
  email: dgray@wehi.edu.au
  organization: The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27857075$$D View this record in MEDLINE/PubMed
BookMark eNptkk1r3DAQhkVJadJtTr0XQy-F1K0-7Fi-FEpI28BCL-lZjEfjXS22tJHskP33VbJJ2JTqMCOkR-98aN6yIx88MfZe8C-CK_3VYxjHJJSq1St2InklStFIdXSwP2anKW14XqoVuqresGPZ6LrhTX3C7pbOE8Ri7tzN7CbnC1xDtpASjd2wK7L-dqC77EO0zsNEqRiyLab1bnRYXJdIw1BY1_cUyU8OJhfye2-LSKs5oyHunqh1GCmkCZJL79jrHoZEp49-wf78uLy--FUuf_-8uvi-LLEWcipJ9ZIq2QHWxAUpCRWixqYlbqHuAS1WtuXnqBvdS101qIFrpSRBg60itWBXe10bYGO20Y0QdyaAMw8HIa4MxMnhQAaF5dLqXmFvKzoXAFCrDiTlYJqUzVrf9lrbuRvJYi43wvBC9OWNd2uzCrcml8JlTmvBPj0KxHAzU5rM6NJ9Z8BTmJPJ3yOaVun8nwv28R90E-boc6seKMF1W1eZOttTGENKkfrnZAQ39wNiDgYk0x8O839mn8YhA5_3QMpXfkXxIOh_9P4COjvMQA
CitedBy_id crossref_primary_10_1016_j_isci_2020_101939
crossref_primary_10_1042_BCJ20210606
crossref_primary_10_1038_s41392_020_00421_2
crossref_primary_10_1038_s41467_024_47289_2
crossref_primary_10_1016_j_cellimm_2018_11_001
crossref_primary_10_4049_jimmunol_1701526
crossref_primary_10_1073_pnas_2120149119
crossref_primary_10_1111_febs_16699
crossref_primary_10_3892_ol_2020_11850
crossref_primary_10_1016_j_lfs_2020_118258
crossref_primary_10_1038_s41467_018_06155_8
crossref_primary_10_1038_s41388_023_02669_8
crossref_primary_10_1016_j_immuni_2019_01_004
crossref_primary_10_1038_ni_3772
crossref_primary_10_1016_j_celrep_2022_110922
crossref_primary_10_1038_s41418_021_00850_8
crossref_primary_10_3389_fcell_2021_686395
crossref_primary_10_1038_s41467_019_11858_7
crossref_primary_10_1016_j_it_2020_10_013
crossref_primary_10_1038_s41419_023_06183_3
crossref_primary_10_4049_jimmunol_2100173
crossref_primary_10_1186_s40164_023_00394_2
crossref_primary_10_3389_fimmu_2024_1359933
crossref_primary_10_1038_s41577_018_0020_8
crossref_primary_10_3390_v15081761
crossref_primary_10_1038_s41590_024_01817_w
crossref_primary_10_3389_fimmu_2021_626172
crossref_primary_10_3892_ol_2022_13514
crossref_primary_10_1038_s41590_019_0381_6
crossref_primary_10_1093_intimm_dxac047
crossref_primary_10_1111_imcb_12039
crossref_primary_10_3389_fonc_2018_00498
crossref_primary_10_3390_ijms21093381
crossref_primary_10_1074_jbc_RA119_011622
crossref_primary_10_1111_imr_12532
crossref_primary_10_1038_nmeth_4228
crossref_primary_10_3390_biomedicines10061436
crossref_primary_10_1016_j_xcrm_2022_100655
crossref_primary_10_1074_jbc_RA118_005449
crossref_primary_10_1074_jbc_RA118_005802
crossref_primary_10_1111_imr_12551
crossref_primary_10_1007_s10571_020_01023_w
crossref_primary_10_1098_rsob_170026
Cites_doi 10.1016/j.immuni.2008.02.017
10.1038/ni.2849
10.1038/ni.3206
10.1016/S1097-2765(00)00136-2
10.1182/blood-2013-05-504019
10.1038/emboj.2011.307
10.1126/scisignal.2002187
10.1093/bioinformatics/btq401
10.1038/sj.gene.6364403
10.1097/00002281-200307000-00010
10.1016/j.immuni.2012.05.030
10.1038/46218
10.1093/bioinformatics/btp616
10.1038/nri3155
10.1158/0008-5472.CAN-13-2131
10.1073/pnas.0603089103
10.1016/j.immuni.2006.04.005
10.1038/ni.2590
10.1016/j.molcel.2009.10.013
10.1111/imm.12604
10.1016/j.immuni.2014.10.012
10.1084/jem.20151604
10.1038/ni.2457
10.4049/jimmunol.178.2.953
10.1214/16-AOAS920
10.1038/85294
10.1038/nri3605
10.1084/jem.20121458
10.1146/annurev.immunol.25.022106.141623
10.1016/S1074-7613(00)80527-0
10.1084/jem.20141130
10.1038/emboj.2011.264
10.1093/bioinformatics/btt656
10.1084/jem.20070601
10.1073/pnas.1219242110
10.1016/j.celrep.2014.08.066
10.1038/nature09814
10.3389/fimmu.2012.00278
10.4049/jimmunol.1501050
10.1038/ni.2985
10.1038/ni.3004
10.1073/pnas.0504783102
10.1186/gb-2010-11-3-r25
10.1186/1471-2105-7-261
10.1038/ni834
10.1158/2159-8290.CD-13-0915
10.1093/nar/25.4.917
10.1038/cdd.2014.168
10.1016/j.tibs.2012.11.007
10.1038/nri3667
10.1126/science.1160062
10.1038/ni.3419
10.1093/nar/gkv007
10.1016/S1074-7613(03)00237-1
10.1038/ni.2649
10.1038/ni1355
10.1093/nar/gkt214
10.1038/nature09816
10.4049/jimmunol.166.11.6509
10.1111/febs.12944
10.1038/nri2416
10.1038/ni.3352
10.1093/bioinformatics/bti270
10.7554/eLife.03464
10.7554/eLife.03422
10.1111/j.2517-6161.1995.tb02031.x
ContentType Journal Article
Copyright The Author(s) 2016
Copyright Nature Publishing Group Nov 2016
Copyright © 2016, The Author(s) 2016 The Author(s)
Copyright_xml – notice: The Author(s) 2016
– notice: Copyright Nature Publishing Group Nov 2016
– notice: Copyright © 2016, The Author(s) 2016 The Author(s)
DBID C6C
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/ncomms13353
DatabaseName Springer Nature OA Free Journals
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
Publicly Available Content Database

CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature Open Access Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 13353
ExternalDocumentID oai_doaj_org_article_c1d02d8f3cfd4e61aaa53ba2e9e08e3d
4254010631
10_1038_ncomms13353
27857075
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Australia
GeographicLocations_xml – name: Australia
GrantInformation_xml – fundername: European Research Council
  grantid: 294880
– fundername: Wellcome Trust
GroupedDBID ---
0R~
39C
3V.
4.4
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BAPOH
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EJD
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-c512t-e3f2e42bac5e01e32a4cc8c79e0da5facdc4d906c878f2847c8a08332ea7c93e3
IEDL.DBID RPM
ISSN 2041-1723
IngestDate Tue Oct 22 15:10:55 EDT 2024
Tue Sep 17 21:17:59 EDT 2024
Fri Oct 25 22:03:01 EDT 2024
Thu Oct 10 20:32:36 EDT 2024
Fri Nov 22 03:12:33 EST 2024
Tue Aug 27 13:50:52 EDT 2024
Fri Oct 11 20:46:05 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c512t-e3f2e42bac5e01e32a4cc8c79e0da5facdc4d906c878f2847c8a08332ea7c93e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Present address: ANZAC Research Institute, Concord Repatriation General Hospital, Concord, New South Wales 2139, Australia
ORCID 0000-0002-7611-5774
0000-0002-3009-5472
0000-0001-9221-2892
0000-0002-0165-3324
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120208/
PMID 27857075
PQID 1841108954
PQPubID 546298
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_c1d02d8f3cfd4e61aaa53ba2e9e08e3d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5120208
proquest_miscellaneous_1841793813
proquest_journals_1841108954
crossref_primary_10_1038_ncomms13353
pubmed_primary_27857075
springer_journals_10_1038_ncomms13353
PublicationCentury 2000
PublicationDate 2016-11-18
PublicationDateYYYYMMDD 2016-11-18
PublicationDate_xml – month: 11
  year: 2016
  text: 2016-11-18
  day: 18
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2016
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Redecke, Chaturvedi, Kuriakose, Hacker (CR25) 2016; 148
Ohteki, Maki, Koyasu (CR43) 2001; 166
O'Reilly (CR57) 2015; 22
CR39
Tani-ichi (CR4) 2013; 110
Ikeda (CR38) 2011; 471
Vahl (CR10) 2014; 41
Lindsten (CR54) 2000; 6
Peltzer (CR18) 2014; 9
Gerlach (CR19) 2011; 471
HogenEsch (CR20) 1993; 143
Singer, Adoro, Park (CR27) 2008; 8
Yang (CR35) 2014; 4
Liston, Gray (CR11) 2014; 14
Jost (CR36) 2007; 178
Benjamini, Hochberg (CR66) 1995; 57
Rieser, Cordier, Walczak (CR14) 2013; 38
Strasser, Cory, Adams (CR32) 2011; 30
Mingueneau (CR1) 2013; 14
Wing (CR46) 2008; 322
Hsieh, Lee, Lio (CR7) 2012; 12
Sasaki (CR37) 2006; 24
Webb, Ley, Seddon (CR51) 2016; 213
Akiyama, Shinzawa, Akiyama (CR30) 2012; 3
Gambineri, Torgerson, Ochs (CR44) 2003; 15
Ritchie (CR61) 2015; 43
Pierson (CR52) 2013; 14
Daley, Hu, Goodnow (CR29) 2013; 210
Goldrath, Bevan (CR24) 1999; 402
Gray (CR31) 2012; 37
Oestreich (CR41) 2014; 15
Ritchie (CR63) 2006; 7
Phipson, L., Majewski, Alexander, Smyth (CR65) 2016; 10
CR17
Boisson (CR23) 2015; 212
Dubois (CR34) 2014; 123
Hogquist, Xing, Hsu, Shapiro (CR3) 2015; 195
Silke, Rickard, Gerlic (CR40) 2015; 16
Park (CR26) 2016; 17
Xing, Wang, Jameson, Hogquist (CR5) 2016; 17
Mackay (CR16) 2014; 74
Haas (CR50) 2009; 36
Josefowicz, Lu, Rudensky (CR6) 2012; 30
Klein, Kyewski, Allen, Hogquist (CR28) 2014; 14
Smyth, Michaud, Scott (CR64) 2005; 21
Wolfer (CR53) 2001; 2
Mahmud (CR8) 2014; 15
Liao, Smyth, Shi (CR58) 2013; 41
Liu, Xie, Schneider, Chen (CR48) 2006; 103
Schmidt-Supprian (CR47) 2003; 19
Wan, Chi, Xie, Schneider, Flavell (CR49) 2006; 7
Wu (CR68) 2010; 26
Penninger (CR42) 1997; 7
Rubtsov (CR45) 2008; 28
Takeuchi (CR55) 2005; 102
Robinson, Oshlack (CR62) 2010; 11
Seymour (CR21) 2007; 8
Fiil, Gyrd-Hansen (CR13) 2014; 281
CR67
McCaughtry, Wilken, Hogquist (CR2) 2007; 204
Niu, Shi, Iwai, Wu (CR15) 2011; 30
Robinson, McCarthy, Smyth (CR60) 2010; 26
Emmerich, Schmukle, Walczak (CR12) 2011; 4
Rathmell, Lindsten, Zong, Cinalli, Thompson (CR33) 2002; 3
Levine, Arvey, Jin, Rudensky (CR9) 2014; 15
Liao, Smyth, Shi (CR59) 2014; 30
Boisson (CR22) 2012; 13
Lemckert, Sedgwick, Korner (CR56) 1997; 25
W Pierson (BFncomms13353_CR52) 2013; 14
Y Yang (BFncomms13353_CR35) 2014; 4
SR Daley (BFncomms13353_CR29) 2013; 210
B Gerlach (BFncomms13353_CR19) 2011; 471
Y Xing (BFncomms13353_CR5) 2016; 17
N Peltzer (BFncomms13353_CR18) 2014; 9
PJ Jost (BFncomms13353_CR36) 2007; 178
HH Liu (BFncomms13353_CR48) 2006; 103
T Lindsten (BFncomms13353_CR54) 2000; 6
A Liston (BFncomms13353_CR11) 2014; 14
AG Levine (BFncomms13353_CR9) 2014; 15
T Ohteki (BFncomms13353_CR43) 2001; 166
K Wing (BFncomms13353_CR46) 2008; 322
Y Liao (BFncomms13353_CR58) 2013; 41
ME Ritchie (BFncomms13353_CR63) 2006; 7
D Wu (BFncomms13353_CR68) 2010; 26
AW Goldrath (BFncomms13353_CR24) 1999; 402
B Boisson (BFncomms13353_CR23) 2015; 212
A Strasser (BFncomms13353_CR32) 2011; 30
TL Haas (BFncomms13353_CR50) 2009; 36
YP Rubtsov (BFncomms13353_CR45) 2008; 28
YY Wan (BFncomms13353_CR49) 2006; 7
BK Fiil (BFncomms13353_CR13) 2014; 281
ME Ritchie (BFncomms13353_CR61) 2015; 43
MD Robinson (BFncomms13353_CR62) 2010; 11
GK Smyth (BFncomms13353_CR64) 2005; 21
BFncomms13353_CR17
CS Hsieh (BFncomms13353_CR7) 2012; 12
SM Dubois (BFncomms13353_CR34) 2014; 123
LV Webb (BFncomms13353_CR51) 2016; 213
DH Gray (BFncomms13353_CR31) 2012; 37
Y Benjamini (BFncomms13353_CR66) 1995; 57
M Mingueneau (BFncomms13353_CR1) 2013; 14
J Niu (BFncomms13353_CR15) 2011; 30
SZ Josefowicz (BFncomms13353_CR6) 2012; 30
A Singer (BFncomms13353_CR27) 2008; 8
KJ Oestreich (BFncomms13353_CR41) 2014; 15
E Rieser (BFncomms13353_CR14) 2013; 38
Y Sasaki (BFncomms13353_CR37) 2006; 24
BFncomms13353_CR67
B Boisson (BFncomms13353_CR22) 2012; 13
V Redecke (BFncomms13353_CR25) 2016; 148
RE Seymour (BFncomms13353_CR21) 2007; 8
C Mackay (BFncomms13353_CR16) 2014; 74
J Silke (BFncomms13353_CR40) 2015; 16
E Gambineri (BFncomms13353_CR44) 2003; 15
Y Liao (BFncomms13353_CR59) 2014; 30
A Wolfer (BFncomms13353_CR53) 2001; 2
JM Penninger (BFncomms13353_CR42) 1997; 7
TM McCaughtry (BFncomms13353_CR2) 2007; 204
KA Hogquist (BFncomms13353_CR3) 2015; 195
SA Mahmud (BFncomms13353_CR8) 2014; 15
BFncomms13353_CR39
M Schmidt-Supprian (BFncomms13353_CR47) 2003; 19
FA Lemckert (BFncomms13353_CR56) 1997; 25
JC Rathmell (BFncomms13353_CR33) 2002; 3
H HogenEsch (BFncomms13353_CR20) 1993; 143
L Klein (BFncomms13353_CR28) 2014; 14
JC Vahl (BFncomms13353_CR10) 2014; 41
T Akiyama (BFncomms13353_CR30) 2012; 3
CH Emmerich (BFncomms13353_CR12) 2011; 4
MD Robinson (BFncomms13353_CR60) 2010; 26
B Phipson (BFncomms13353_CR65) 2016; 10
O Takeuchi (BFncomms13353_CR55) 2005; 102
S Tani-ichi (BFncomms13353_CR4) 2013; 110
LA O'Reilly (BFncomms13353_CR57) 2015; 22
Y Park (BFncomms13353_CR26) 2016; 17
F Ikeda (BFncomms13353_CR38) 2011; 471
References_xml – volume: 28
  start-page: 546
  year: 2008
  end-page: 558
  ident: CR45
  article-title: Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.02.017
  contributor:
    fullname: Rubtsov
– volume: 15
  start-page: 473
  year: 2014
  end-page: 481
  ident: CR8
  article-title: Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2849
  contributor:
    fullname: Mahmud
– volume: 16
  start-page: 689
  year: 2015
  end-page: 697
  ident: CR40
  article-title: The diverse role of RIP kinases in necroptosis and inflammation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3206
  contributor:
    fullname: Gerlic
– volume: 6
  start-page: 1389
  year: 2000
  end-page: 1399
  ident: CR54
  article-title: The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(00)00136-2
  contributor:
    fullname: Lindsten
– volume: 123
  start-page: 2199
  year: 2014
  end-page: 2203
  ident: CR34
  article-title: A catalytic-independent role for the LUBAC in NF-kappaB activation upon antigen receptor engagement and in lymphoma cells
  publication-title: Blood
  doi: 10.1182/blood-2013-05-504019
  contributor:
    fullname: Dubois
– volume: 30
  start-page: 3667
  year: 2011
  end-page: 3683
  ident: CR32
  article-title: Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.307
  contributor:
    fullname: Adams
– ident: CR39
– volume: 4
  start-page: re5
  year: 2011
  ident: CR12
  article-title: The emerging role of linear ubiquitination in cell signaling
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2002187
  contributor:
    fullname: Walczak
– volume: 26
  start-page: 2176
  year: 2010
  end-page: 2182
  ident: CR68
  article-title: ROAST: rotation gene set tests for complex microarray experiments
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq401
  contributor:
    fullname: Wu
– volume: 8
  start-page: 416
  year: 2007
  end-page: 421
  ident: CR21
  article-title: Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis
  publication-title: Genes Immunity
  doi: 10.1038/sj.gene.6364403
  contributor:
    fullname: Seymour
– volume: 15
  start-page: 430
  year: 2003
  end-page: 435
  ident: CR44
  article-title: Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/00002281-200307000-00010
  contributor:
    fullname: Ochs
– volume: 37
  start-page: 451
  year: 2012
  end-page: 462
  ident: CR31
  article-title: The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.05.030
  contributor:
    fullname: Gray
– volume: 402
  start-page: 255
  year: 1999
  end-page: 262
  ident: CR24
  article-title: Selecting and maintaining a diverse T-cell repertoire
  publication-title: Nature
  doi: 10.1038/46218
  contributor:
    fullname: Bevan
– volume: 26
  start-page: 139
  year: 2010
  end-page: 140
  ident: CR60
  article-title: K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
  contributor:
    fullname: Smyth
– volume: 12
  start-page: 157
  year: 2012
  end-page: 167
  ident: CR7
  article-title: Selection of regulatory T cells in the thymus
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3155
  contributor:
    fullname: Lio
– volume: 74
  start-page: 2246
  year: 2014
  end-page: 2257
  ident: CR16
  article-title: E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-2131
  contributor:
    fullname: Mackay
– volume: 103
  start-page: 11677
  year: 2006
  end-page: 11682
  ident: CR48
  article-title: Essential role of TAK1 in thymocyte development and activation
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0603089103
  contributor:
    fullname: Chen
– volume: 24
  start-page: 729
  year: 2006
  end-page: 739
  ident: CR37
  article-title: Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.04.005
  contributor:
    fullname: Sasaki
– volume: 14
  start-page: 619
  year: 2013
  end-page: 632
  ident: CR1
  article-title: The transcriptional landscape of alphabeta T cell differentiation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2590
  contributor:
    fullname: Mingueneau
– volume: 36
  start-page: 831
  year: 2009
  end-page: 844
  ident: CR50
  article-title: Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.10.013
  contributor:
    fullname: Haas
– volume: 148
  start-page: 216
  year: 2016
  end-page: 226
  ident: CR25
  article-title: SHARPIN controls the development of regulatory T cells
  publication-title: Immunology
  doi: 10.1111/imm.12604
  contributor:
    fullname: Hacker
– volume: 41
  start-page: 722
  year: 2014
  end-page: 736
  ident: CR10
  article-title: Continuous T cell receptor signals maintain a functional regulatory T cell pool
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.10.012
  contributor:
    fullname: Vahl
– volume: 213
  start-page: 1399
  year: 2016
  end-page: 1407
  ident: CR51
  article-title: TNF activation of NF-kappaB is essential for development of single-positive thymocytes
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20151604
  contributor:
    fullname: Seddon
– volume: 13
  start-page: 1178
  year: 2012
  end-page: 1186
  ident: CR22
  article-title: Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2457
  contributor:
    fullname: Boisson
– volume: 178
  start-page: 953
  year: 2007
  end-page: 960
  ident: CR36
  article-title: Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.178.2.953
  contributor:
    fullname: Jost
– ident: CR67
– volume: 10
  start-page: 946
  year: 2016
  end-page: 963
  ident: CR65
  article-title: Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
  publication-title: Ann. Appl. Stat.
  doi: 10.1214/16-AOAS920
  contributor:
    fullname: Smyth
– volume: 2
  start-page: 235
  year: 2001
  end-page: 241
  ident: CR53
  article-title: Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
  publication-title: Nat. Immunol.
  doi: 10.1038/85294
  contributor:
    fullname: Wolfer
– volume: 14
  start-page: 154
  year: 2014
  end-page: 165
  ident: CR11
  article-title: Homeostatic control of regulatory T cell diversity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3605
  contributor:
    fullname: Gray
– volume: 210
  start-page: 269
  year: 2013
  end-page: 285
  ident: CR29
  article-title: Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-kappaB
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20121458
  contributor:
    fullname: Goodnow
– volume: 30
  start-page: 531
  year: 2012
  end-page: 564
  ident: CR6
  article-title: Regulatory T cells: mechanisms of differentiation and function
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.25.022106.141623
  contributor:
    fullname: Rudensky
– volume: 7
  start-page: 243
  year: 1997
  end-page: 254
  ident: CR42
  article-title: The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80527-0
  contributor:
    fullname: Penninger
– volume: 212
  start-page: 939
  year: 2015
  end-page: 951
  ident: CR23
  article-title: Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20141130
  contributor:
    fullname: Boisson
– volume: 30
  start-page: 3741
  year: 2011
  end-page: 3753
  ident: CR15
  article-title: LUBAC regulates NF-kappaB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.264
  contributor:
    fullname: Wu
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: CR59
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
  contributor:
    fullname: Shi
– volume: 204
  start-page: 2513
  year: 2007
  end-page: 2520
  ident: CR2
  article-title: Thymic emigration revisited
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20070601
  contributor:
    fullname: Hogquist
– volume: 110
  start-page: 612
  year: 2013
  end-page: 617
  ident: CR4
  article-title: Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations
  publication-title: Proc. Natl acad. Sci. USA
  doi: 10.1073/pnas.1219242110
  contributor:
    fullname: Tani-ichi
– volume: 9
  start-page: 153
  year: 2014
  end-page: 165
  ident: CR18
  article-title: HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.08.066
  contributor:
    fullname: Peltzer
– volume: 143
  start-page: 972
  year: 1993
  end-page: 982
  ident: CR20
  article-title: A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice
  publication-title: Am. J. Pathol.
  contributor:
    fullname: HogenEsch
– volume: 471
  start-page: 637
  year: 2011
  end-page: 641
  ident: CR38
  article-title: SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis
  publication-title: Nature
  doi: 10.1038/nature09814
  contributor:
    fullname: Ikeda
– volume: 3
  start-page: 278
  year: 2012
  ident: CR30
  article-title: TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2012.00278
  contributor:
    fullname: Akiyama
– volume: 195
  start-page: 1351
  year: 2015
  end-page: 1357
  ident: CR3
  article-title: T cell adolescence: maturation events beyond positive selection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1501050
  contributor:
    fullname: Shapiro
– volume: 15
  start-page: 957
  year: 2014
  end-page: 964
  ident: CR41
  article-title: Bcl-6 directly represses the gene program of the glycolysis pathway
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2985
  contributor:
    fullname: Oestreich
– volume: 15
  start-page: 1070
  year: 2014
  end-page: 1078
  ident: CR9
  article-title: Continuous requirement for the TCR in regulatory T cell function
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3004
  contributor:
    fullname: Rudensky
– volume: 102
  start-page: 11272
  year: 2005
  end-page: 11277
  ident: CR55
  article-title: Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0504783102
  contributor:
    fullname: Takeuchi
– volume: 11
  start-page: R25
  year: 2010
  ident: CR62
  article-title: A scaling normalization method for differential expression analysis of RNA-seq data
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
  contributor:
    fullname: Oshlack
– volume: 7
  start-page: 261
  year: 2006
  ident: CR63
  article-title: Empirical array quality weights in the analysis of microarray data
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-7-261
  contributor:
    fullname: Ritchie
– volume: 3
  start-page: 932
  year: 2002
  end-page: 939
  ident: CR33
  article-title: Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
  publication-title: Nat. Immunol.
  doi: 10.1038/ni834
  contributor:
    fullname: Thompson
– volume: 4
  start-page: 480
  year: 2014
  end-page: 493
  ident: CR35
  article-title: Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-13-0915
  contributor:
    fullname: Yang
– volume: 25
  start-page: 917
  year: 1997
  end-page: 918
  ident: CR56
  article-title: Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/25.4.917
  contributor:
    fullname: Korner
– volume: 22
  start-page: 767
  year: 2015
  end-page: 778
  ident: CR57
  article-title: Loss of c-REL but not NF-kappaB2 prevents autoimmune disease driven by FasL mutation
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2014.168
  contributor:
    fullname: O'Reilly
– volume: 38
  start-page: 94
  year: 2013
  end-page: 102
  ident: CR14
  article-title: Linear ubiquitination: a newly discovered regulator of cell signalling
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2012.11.007
  contributor:
    fullname: Walczak
– volume: 14
  start-page: 377
  year: 2014
  end-page: 391
  ident: CR28
  article-title: Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3667
  contributor:
    fullname: Hogquist
– volume: 322
  start-page: 271
  year: 2008
  end-page: 275
  ident: CR46
  article-title: CTLA-4 control over Foxp3+ regulatory T cell function
  publication-title: Science
  doi: 10.1126/science.1160062
  contributor:
    fullname: Wing
– volume: 17
  start-page: 565
  year: 2016
  end-page: 573
  ident: CR5
  article-title: Late stages of T cell maturation in the thymus involve NF-kappaB and tonic type I interferon signaling
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3419
  contributor:
    fullname: Hogquist
– volume: 43
  start-page: e47
  year: 2015
  ident: CR61
  article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
  contributor:
    fullname: Ritchie
– volume: 19
  start-page: 377
  year: 2003
  end-page: 389
  ident: CR47
  article-title: Mature T cells depend on signaling through the IKK complex
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00237-1
  contributor:
    fullname: Schmidt-Supprian
– volume: 14
  start-page: 959
  year: 2013
  end-page: 965
  ident: CR52
  article-title: Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2649
  contributor:
    fullname: Pierson
– volume: 57
  start-page: 289
  year: 1995
  end-page: 300
  ident: CR66
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J. R. Stat. Soc. Ser. B (Methodol.)
  contributor:
    fullname: Hochberg
– volume: 7
  start-page: 851
  year: 2006
  end-page: 858
  ident: CR49
  article-title: The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1355
  contributor:
    fullname: Flavell
– ident: CR17
– volume: 41
  start-page: e108
  year: 2013
  ident: CR58
  article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt214
  contributor:
    fullname: Shi
– volume: 471
  start-page: 591
  year: 2011
  end-page: 596
  ident: CR19
  article-title: Linear ubiquitination prevents inflammation and regulates immune signalling
  publication-title: Nature
  doi: 10.1038/nature09816
  contributor:
    fullname: Gerlach
– volume: 166
  start-page: 6509
  year: 2001
  end-page: 6513
  ident: CR43
  article-title: Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.166.11.6509
  contributor:
    fullname: Koyasu
– volume: 281
  start-page: 4337
  year: 2014
  end-page: 4350
  ident: CR13
  article-title: Met1-linked ubiquitination in immune signalling
  publication-title: FEBS J.
  doi: 10.1111/febs.12944
  contributor:
    fullname: Gyrd-Hansen
– volume: 8
  start-page: 788
  year: 2008
  end-page: 801
  ident: CR27
  article-title: Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2416
  contributor:
    fullname: Park
– volume: 17
  start-page: 286
  year: 2016
  end-page: 296
  ident: CR26
  article-title: SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3352
  contributor:
    fullname: Park
– volume: 21
  start-page: 2067
  year: 2005
  end-page: 2075
  ident: CR64
  article-title: Use of within-array replicate spots for assessing differential expression in microarray experiments
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti270
  contributor:
    fullname: Scott
– volume: 15
  start-page: 473
  year: 2014
  ident: BFncomms13353_CR8
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2849
  contributor:
    fullname: SA Mahmud
– volume: 471
  start-page: 591
  year: 2011
  ident: BFncomms13353_CR19
  publication-title: Nature
  doi: 10.1038/nature09816
  contributor:
    fullname: B Gerlach
– volume: 210
  start-page: 269
  year: 2013
  ident: BFncomms13353_CR29
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20121458
  contributor:
    fullname: SR Daley
– ident: BFncomms13353_CR17
  doi: 10.7554/eLife.03464
– volume: 30
  start-page: 923
  year: 2014
  ident: BFncomms13353_CR59
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
  contributor:
    fullname: Y Liao
– volume: 25
  start-page: 917
  year: 1997
  ident: BFncomms13353_CR56
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/25.4.917
  contributor:
    fullname: FA Lemckert
– volume: 30
  start-page: 3667
  year: 2011
  ident: BFncomms13353_CR32
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.307
  contributor:
    fullname: A Strasser
– ident: BFncomms13353_CR39
  doi: 10.7554/eLife.03422
– volume: 8
  start-page: 416
  year: 2007
  ident: BFncomms13353_CR21
  publication-title: Genes Immunity
  doi: 10.1038/sj.gene.6364403
  contributor:
    fullname: RE Seymour
– volume: 13
  start-page: 1178
  year: 2012
  ident: BFncomms13353_CR22
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2457
  contributor:
    fullname: B Boisson
– volume: 15
  start-page: 430
  year: 2003
  ident: BFncomms13353_CR44
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/00002281-200307000-00010
  contributor:
    fullname: E Gambineri
– volume: 36
  start-page: 831
  year: 2009
  ident: BFncomms13353_CR50
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.10.013
  contributor:
    fullname: TL Haas
– volume: 281
  start-page: 4337
  year: 2014
  ident: BFncomms13353_CR13
  publication-title: FEBS J.
  doi: 10.1111/febs.12944
  contributor:
    fullname: BK Fiil
– volume: 123
  start-page: 2199
  year: 2014
  ident: BFncomms13353_CR34
  publication-title: Blood
  doi: 10.1182/blood-2013-05-504019
  contributor:
    fullname: SM Dubois
– volume: 2
  start-page: 235
  year: 2001
  ident: BFncomms13353_CR53
  publication-title: Nat. Immunol.
  doi: 10.1038/85294
  contributor:
    fullname: A Wolfer
– volume: 402
  start-page: 255
  year: 1999
  ident: BFncomms13353_CR24
  publication-title: Nature
  doi: 10.1038/46218
  contributor:
    fullname: AW Goldrath
– volume: 102
  start-page: 11272
  year: 2005
  ident: BFncomms13353_CR55
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0504783102
  contributor:
    fullname: O Takeuchi
– volume: 30
  start-page: 3741
  year: 2011
  ident: BFncomms13353_CR15
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.264
  contributor:
    fullname: J Niu
– volume: 26
  start-page: 2176
  year: 2010
  ident: BFncomms13353_CR68
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq401
  contributor:
    fullname: D Wu
– volume: 3
  start-page: 278
  year: 2012
  ident: BFncomms13353_CR30
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2012.00278
  contributor:
    fullname: T Akiyama
– volume: 24
  start-page: 729
  year: 2006
  ident: BFncomms13353_CR37
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.04.005
  contributor:
    fullname: Y Sasaki
– volume: 57
  start-page: 289
  year: 1995
  ident: BFncomms13353_CR66
  publication-title: J. R. Stat. Soc. Ser. B (Methodol.)
  doi: 10.1111/j.2517-6161.1995.tb02031.x
  contributor:
    fullname: Y Benjamini
– volume: 9
  start-page: 153
  year: 2014
  ident: BFncomms13353_CR18
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.08.066
  contributor:
    fullname: N Peltzer
– volume: 103
  start-page: 11677
  year: 2006
  ident: BFncomms13353_CR48
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0603089103
  contributor:
    fullname: HH Liu
– volume: 17
  start-page: 565
  year: 2016
  ident: BFncomms13353_CR5
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3419
  contributor:
    fullname: Y Xing
– volume: 11
  start-page: R25
  year: 2010
  ident: BFncomms13353_CR62
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
  contributor:
    fullname: MD Robinson
– volume: 37
  start-page: 451
  year: 2012
  ident: BFncomms13353_CR31
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.05.030
  contributor:
    fullname: DH Gray
– volume: 26
  start-page: 139
  year: 2010
  ident: BFncomms13353_CR60
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
  contributor:
    fullname: MD Robinson
– volume: 166
  start-page: 6509
  year: 2001
  ident: BFncomms13353_CR43
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.166.11.6509
  contributor:
    fullname: T Ohteki
– volume: 41
  start-page: e108
  year: 2013
  ident: BFncomms13353_CR58
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt214
  contributor:
    fullname: Y Liao
– volume: 10
  start-page: 946
  year: 2016
  ident: BFncomms13353_CR65
  publication-title: Ann. Appl. Stat.
  doi: 10.1214/16-AOAS920
  contributor:
    fullname: B Phipson
– volume: 30
  start-page: 531
  year: 2012
  ident: BFncomms13353_CR6
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.25.022106.141623
  contributor:
    fullname: SZ Josefowicz
– volume: 14
  start-page: 154
  year: 2014
  ident: BFncomms13353_CR11
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3605
  contributor:
    fullname: A Liston
– volume: 213
  start-page: 1399
  year: 2016
  ident: BFncomms13353_CR51
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20151604
  contributor:
    fullname: LV Webb
– volume: 3
  start-page: 932
  year: 2002
  ident: BFncomms13353_CR33
  publication-title: Nat. Immunol.
  doi: 10.1038/ni834
  contributor:
    fullname: JC Rathmell
– volume: 21
  start-page: 2067
  year: 2005
  ident: BFncomms13353_CR64
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti270
  contributor:
    fullname: GK Smyth
– volume: 212
  start-page: 939
  year: 2015
  ident: BFncomms13353_CR23
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20141130
  contributor:
    fullname: B Boisson
– volume: 204
  start-page: 2513
  year: 2007
  ident: BFncomms13353_CR2
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20070601
  contributor:
    fullname: TM McCaughtry
– volume: 14
  start-page: 619
  year: 2013
  ident: BFncomms13353_CR1
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2590
  contributor:
    fullname: M Mingueneau
– volume: 7
  start-page: 243
  year: 1997
  ident: BFncomms13353_CR42
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80527-0
  contributor:
    fullname: JM Penninger
– volume: 12
  start-page: 157
  year: 2012
  ident: BFncomms13353_CR7
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3155
  contributor:
    fullname: CS Hsieh
– volume: 143
  start-page: 972
  year: 1993
  ident: BFncomms13353_CR20
  publication-title: Am. J. Pathol.
  contributor:
    fullname: H HogenEsch
– volume: 322
  start-page: 271
  year: 2008
  ident: BFncomms13353_CR46
  publication-title: Science
  doi: 10.1126/science.1160062
  contributor:
    fullname: K Wing
– volume: 28
  start-page: 546
  year: 2008
  ident: BFncomms13353_CR45
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.02.017
  contributor:
    fullname: YP Rubtsov
– volume: 7
  start-page: 851
  year: 2006
  ident: BFncomms13353_CR49
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1355
  contributor:
    fullname: YY Wan
– volume: 7
  start-page: 261
  year: 2006
  ident: BFncomms13353_CR63
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-7-261
  contributor:
    fullname: ME Ritchie
– volume: 74
  start-page: 2246
  year: 2014
  ident: BFncomms13353_CR16
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-2131
  contributor:
    fullname: C Mackay
– ident: BFncomms13353_CR67
– volume: 16
  start-page: 689
  year: 2015
  ident: BFncomms13353_CR40
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3206
  contributor:
    fullname: J Silke
– volume: 471
  start-page: 637
  year: 2011
  ident: BFncomms13353_CR38
  publication-title: Nature
  doi: 10.1038/nature09814
  contributor:
    fullname: F Ikeda
– volume: 15
  start-page: 1070
  year: 2014
  ident: BFncomms13353_CR9
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3004
  contributor:
    fullname: AG Levine
– volume: 19
  start-page: 377
  year: 2003
  ident: BFncomms13353_CR47
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00237-1
  contributor:
    fullname: M Schmidt-Supprian
– volume: 38
  start-page: 94
  year: 2013
  ident: BFncomms13353_CR14
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2012.11.007
  contributor:
    fullname: E Rieser
– volume: 41
  start-page: 722
  year: 2014
  ident: BFncomms13353_CR10
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.10.012
  contributor:
    fullname: JC Vahl
– volume: 8
  start-page: 788
  year: 2008
  ident: BFncomms13353_CR27
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2416
  contributor:
    fullname: A Singer
– volume: 15
  start-page: 957
  year: 2014
  ident: BFncomms13353_CR41
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2985
  contributor:
    fullname: KJ Oestreich
– volume: 110
  start-page: 612
  year: 2013
  ident: BFncomms13353_CR4
  publication-title: Proc. Natl acad. Sci. USA
  doi: 10.1073/pnas.1219242110
  contributor:
    fullname: S Tani-ichi
– volume: 43
  start-page: e47
  year: 2015
  ident: BFncomms13353_CR61
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
  contributor:
    fullname: ME Ritchie
– volume: 4
  start-page: re5
  year: 2011
  ident: BFncomms13353_CR12
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2002187
  contributor:
    fullname: CH Emmerich
– volume: 22
  start-page: 767
  year: 2015
  ident: BFncomms13353_CR57
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2014.168
  contributor:
    fullname: LA O'Reilly
– volume: 148
  start-page: 216
  year: 2016
  ident: BFncomms13353_CR25
  publication-title: Immunology
  doi: 10.1111/imm.12604
  contributor:
    fullname: V Redecke
– volume: 4
  start-page: 480
  year: 2014
  ident: BFncomms13353_CR35
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-13-0915
  contributor:
    fullname: Y Yang
– volume: 14
  start-page: 959
  year: 2013
  ident: BFncomms13353_CR52
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2649
  contributor:
    fullname: W Pierson
– volume: 6
  start-page: 1389
  year: 2000
  ident: BFncomms13353_CR54
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(00)00136-2
  contributor:
    fullname: T Lindsten
– volume: 195
  start-page: 1351
  year: 2015
  ident: BFncomms13353_CR3
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1501050
  contributor:
    fullname: KA Hogquist
– volume: 14
  start-page: 377
  year: 2014
  ident: BFncomms13353_CR28
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3667
  contributor:
    fullname: L Klein
– volume: 17
  start-page: 286
  year: 2016
  ident: BFncomms13353_CR26
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3352
  contributor:
    fullname: Y Park
– volume: 178
  start-page: 953
  year: 2007
  ident: BFncomms13353_CR36
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.178.2.953
  contributor:
    fullname: PJ Jost
SSID ssj0000391844
Score 2.4671204
Snippet The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we...
LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 13353
SubjectTerms 13/1
13/106
13/31
13/95
38/91
631/250/1619/554/1898/1271
631/250/2152/1566/2493
631/250/516/1909
64/110
82/80
96/34
Animals
Apoptosis
Base Sequence
Cell Differentiation - physiology
Cells
Cells, Cultured
Chemokines
Computational Biology
Cytokines
Dermatitis
Gene Expression Regulation - physiology
Genotype
Homeostasis
Homeostasis - physiology
Humanities and Social Sciences
Lymphocytes
Mice
multidisciplinary
Protein Multimerization
Protein Processing, Post-Translational
RNA - genetics
Science
Science (multidisciplinary)
Sequence Analysis, RNA
T-Lymphocytes - classification
T-Lymphocytes - physiology
Thymus Gland - cytology
Tumor necrosis factor-TNF
Ubiquitin - chemistry
Ubiquitin - metabolism
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlUOiltOnLaRJUSI8mth62fGxLQ-ihpwRyM3qMWEPWbne9kP33HUn2stsUesnFBkuH4ZuR5htrNEPIhVCuNI41uWae58I5kxsPLq_qQhecC1b7mCD7s7q-FT_u5N1eq6-QE5bKAyfgLm3pCuaU59Y7AVWptZbcaAYNFAq4i7tvwfaCqbgH8wZDFzFdyCu4uuxRgcs1RmSSH7igWKn_X_TycZbkX0el0QNdvSIvJ-pIvySRX5Nn0B-T56mZ5PYNecCwEs2Wbkz3e9ONXU_tAsN-iuwYluZ-S2P2ODzgGwPOrg8kk97jk6Kulp2lN3n4i0_nliljUhrVvaOr1LF-WG3nWYthCQMyy3W3fktur77ffLvOp74KuUX3PubAPQPBjLYSihI408JaZWtE1GnptXVWuKaorKqVD-7LKo1MjTPQtW048HfkqB96-ECo9QaQBVRO6kYIgIaF-i5MWg5GCMEzcjFD3f5K5TPaeOzNVbunkYx8DWrYTQk1r-MHtIR2soT2f5aQkdNZie20ENctWkG46NBIkZFPu2FcQgEr3cOwSXNwm1IlyvE-6XwnCatDB4BaZqQ-sIYDUQ9H-m4Ry3Qj1qEDakY-z3azJ9ZjDE6eAoOP5AUyuipclizVKTkaVxs4Q9Y0mvO4QP4AIeodxw
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k1oQUYqR6uJ7STOqQLEUnHg1Eq9RX6M2Uhdp91kpe6_Z5zH0qWISyLFVjSaGXu-GY9nCDmWymXG8Ypp7gWTzhlmPDhWlKlOhZC89EOC7M_i7EL-uMwvp4BbN6VVznvisFG71sYY-Ql6IjFjvcrl6fUNi12j4unq1ELjIXmU8bKIKX1q8X0XY4nVz5WU07W8VKiTgL9cdeiX5WLPEA31-v8FMu_nSv51YDrYocUz8nQCkPTzKPHn5AGEF-Tx2FJy-5LconOJyks3prnZNH0TqF2i808RI8PKXG3pkEMOt_hGt7MJEWrSK3xSlNiqsfScxVg-nRun9KPoqA6Orse-9e16O89atitoEV92TfeKXCy-nX89Y1N3BWbRyPcMhOcgudE2hzQDwbW0VtmygtTp3GvrrHRVWlhVKh-NmFUa8ZrgoEtbCRCvyUFoA7wl1HoDiAUKl-tKSoCKxyovPLcCjJRSJOR4ZnV9PRbRqIfDb6HqOxJJyJcoht2UWPl6-NCuf9XTQqpt5lLulBfWOwlFprXOhdEckG4FwiXkaBZiPS3Hrv6jPAn5uBvGhRR5pQO0m3EOblYqQzrejDLfUcLL2AegzBNS7mnDHqn7I6FZDsW6kdexD2pCPs16c4es-zx493_yD8kTRGxFvAyZqSNy0K838B5RUW8-DKr_G7UKE3A
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB7SlEIvIX07TYsK6dGtLcm2fAilLQ2h0J6ykJvRY9w17NqN1wu7_74jP5ZskkMvMlgyDPPQfGNpZgDOpHKxcTwPNS9FKJ0zoSnRhWkW6UgIybOyvyD7O72cyZ_XyfUBTM04RwauHgztfD-pWbv4tLnZfiGDPx9SxtXnmmSzXFGwlYhH8JiTS_R3u36NOL_fkkVOkYw_YeaRjENy2mLM1bvz_Z536ov4P4Q871-gvHOK2juni2M4GlEl-zqowTM4wPo5PBn6TG5fwIYiTtJotjbVzbrqqprZuaaRgDMuzWLL-ovluKEnxaJV7fEnW9DISIzLyrKr0P_gZ1M3lW6QJ9O1Y-3QzL5pt9OqebPEhkDnqlq9hNnFj6vvl-HYciG05Pm7EEXJUXKjbYJRjIJraa2yWY6R00mprbPS5VFqVaZK79ms0gTiBEed2VygeAWHdVPjG2C2NEgAIXWJzqVEzLkv_cITK9BIKUUAZxOri79DZY2iPxEXqrglkQC-eTHslvhy2P2Lpv1TjNZV2NhF3KlS2NJJTGOtdSKM5kh0KxQugNNJiMWkYgVphM-ByBMZwIfdNFmX55WusVkPa2gHUzHR8XqQ-Y4SnvnmAFkSQLanDXuk7s_U1byv4E289s1RA_g46c0tsu7z4OT_WPUWnhKcS32mZKxO4bBr1_iOIFNn3vfm8A-K5Rsa
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB7SlEIvpenTbRJUmh5NbUm25WO7JIQeekogN6PHiDVk7XTXC9l_35EfS5z00IsN9hiGeXi-kTQzAGdSudQ4XsaaexFL50xsPLo4LxKdCCF54fsDsr_zy2v56ya7OYCvUy3MbP9eqO8NyX21oUQqE8_gOQXfIpjxIl_sF1JCi3Ml5Vh79-ibWbTpm_L_C0k-PRD5aFe0DzYXr-HViBLZj0GtR3CAzRt4McyN3L2Fe8ogyULZ1tR_tnVXN8wuKcNnBIRxZW53rD8ojvd0p9yybgKeZLd0ZaSWVW3ZVRwW7Nk0HaUb9MN049h6GE7frncT1bJdYUsgclNv3sH1xfnV4jIeRyjEliJ5F6PwHCU32maYpCi4ltYqW5SYOJ15bZ2VrkxyqwrlQ6SyShMoExx1YUuB4j0cNm2DH4FZb5ACfu4yXUqJWPLQyoVnVqCRUooIziZRV3dDp4yq3-EWqnqgkQh-BjXsSUJ76_4Bab0avaWyqUu4U15Y7yTmqdY6E0ZzJL4VChfB8aTEavS5TUVWEGoaykxG8GX_mrwlyEo32G4HGvojqZT4-DDofM8JL0Kz_yKLoJhZw4zV-ZumXvYduUnWYdhpBN8mu3nA1lMZfPpPus_wkvBZHkofU3UMh916iyeEgTpz2vvAX8mHCzE
  priority: 102
  providerName: Springer Nature
Title Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
URI https://link.springer.com/article/10.1038/ncomms13353
https://www.ncbi.nlm.nih.gov/pubmed/27857075
https://www.proquest.com/docview/1841108954
https://search.proquest.com/docview/1841793813
https://pubmed.ncbi.nlm.nih.gov/PMC5120208
https://doaj.org/article/c1d02d8f3cfd4e61aaa53ba2e9e08e3d
Volume 7
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBdtx2AvY9_z1gUNukc3tiTb8mMampVAS9layJuRpfNiiO0uH9D89zvJdkjWPe1FAkvg4-6k-510uiPkTEgT5oalvmIF94UxuZ8XYPw4CVTAuWBJ4QJkb-KrezGdRbMjEvVvYVzQvs7L83pRndfl3MVWPlR62MeJDW-vx2ikbG3J4TE5RvO756K77Zen6LWI7i1ewOWwRtlVK3TGIls1hyU2p7uNK9wzRC5f_79A5tNYyb8uTJ0dmrwiLzsASUctoa_JEdRvyPO2pOT2LXlE5xKVl27y8vemXJc11XN0_iliZKjyxZa6GHJ4xB7dzrK2UJMusKUosarU9M63Z_m0L5yybkVHVW3osq1b3yy3_ax5U0GD-HJVrt6R-8nl3fjK76or-Br5t_aBFwwEy5WOIAiBMyW0ljpJITAqKpQ2Wpg0iLVMZGGNmJYK8RpnoBKdcuDvyUnd1PCRUF3kgFggNpFKhQBImc3ywiLNIRdCcI-c9azOHtokGpm7_OYy2xOORy6sGHZTbOZr96FZ_so6-Wc6NAEzsuC6MALiUCkV8VwxQLolcOOR016IWbccVxkqhH3ukEbCI193w7iQLK9UDc2mnYOblQyRjg-tzHeU9DrjkeRAGw5IPRxB3XXJujtd9ci3Xm_2yHrKg0___YfP5AWCudi-kwzlKTlZLzfwBQHTOh_gMpkl2MrJ9wF5NhpNf06xv7i8uf2BX8fxeOCOIrC9FnLgltMfQVwj9w
link.rule.ids 230,314,727,780,784,864,885,2102,12056,12765,21388,24318,27924,27925,31719,31720,33373,33374,33744,33745,41120,42189,43310,43600,43805,51576,53791,53793,73745,74035,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3ra9RAEF_0iugX8W206gr1Y2iyj2TzSay0nFoPkSv0W9jHxAv0kvaSg95_72weZ8-KXxLILmGYx-5vZmdnCDkQysXGsSzUrOChcM6EpgAXJmmkI84FS4suQXaWTM_E13N5PgTcmiGtclwTu4Xa1dbHyA_RE_EZ65kUHy-vQt81yp-uDi007pI9XzldTsje0fHsx89tlMXXP1dCDBfzIq4OK_zpskHPTPKdrair2P8vmHk7W_KvI9NuJzp5RB4OEJJ-6mX-mNyB6gm51zeV3Dwl1-heovrStSmv1mVbVtQu0P2niJJhaS42tMsih2t8o-NZVh5s0gt8UpTZsrR0HvpoPh1bp7S98KiuHF31nevr1WactaiXUCPCbMrmGTk7OZ5_noZDf4XQ4jbfhsALBoIZbSVEMXCmhbXKphlETstCW2eFy6LEqlQVfhuzSiNi4wx0ajMO_DmZVHUFLwm1hQFEA4mTOhMCIGO-zguTloMRQvCAHIyszi_7Mhp5d_zNVX5DIgE58mLYTvG1r7sP9epXPphSbmMXMacKbgsnIIm11pIbzQDpVsBdQPZHIeaDQTb5H_UJyPvtMJqS55WuoF73c3C5UjHS8aKX-ZYSlvpOAKkMSLqjDTuk7o5U5aIr14289p1QA_Jh1JsbZN3mwav_k_-O3J_Ov5_mp19m316TB4jfEn81Mlb7ZNKu1vAGMVJr3g6G8BtY_xfB
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Zb9QwELZgKxAviJtAASOVx2gT20mcJ0Shq3JoVaFW6lvkY8xG6ibtJit1_z3jHEuXIl4SKbaU0Ryeb-zxDCEHQtpYW5aHijkeCmt1qB3YMM0iFXEuWOa6BNl5enwmvp0n50P-UzOkVY5rYrdQ29r4PfIpRiI-Yz1PxNQNaREnX2YfL69C30HKn7QO7TTukj30ihGbkL3Do_nJz-2Oi6-FLoUYLulFXE4r_MGywSgt4Ttuqave_y_IeTtz8q_j084rzR6RhwOcpJ96-T8md6B6Qu71DSY3T8k1hpqoynSty6t12ZYVNQuFT0TMsNQXG9pllMM1vjEILSsPPOkFPinKb1kaehr6nX06tlFpe0FSVVm66rvY16vNOGtRL6FGtNmUzTNyNjs6_XwcDr0WQoMuvw2BOwaCaWUSiGLgTAljpMlyiKxKnDLWCJtHqZGZdN6lGakQvXEGKjM5B_6cTKq6gpeEGqcBkUFqE5ULAZAzX_OFJYaDFkLwgByMrC4u-5IaRXcUzmVxQyIBOfRi2E7xdbC7D_XqVzGYVWFiGzErHTfOCkhjpVTCtWKAdEvgNiD7oxCLwTib4o8qBeT9dhjNyvNKVVCv-zm4dMkY6XjRy3xLCct8V4AsCUi2ow07pO6OVOWiK92NvPZdUQPyYdSbG2Td5sGr_5P_jtxHGyh-fJ1_f00eIJRL_S3JWO6TSbtawxuES61-O9jBbwgQG-4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Linear+ubiquitin+chain+assembly+complex+coordinates+late+thymic+T-cell+differentiation+and+regulatory+T-cell+homeostasis&rft.jtitle=Nature+communications&rft.au=Teh%2C+Charis+E.&rft.au=Lalaoui%2C+Najoua&rft.au=Jain%2C+Reema&rft.au=Policheni%2C+Antonia+N.&rft.date=2016-11-18&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=7&rft.issue=1&rft_id=info:doi/10.1038%2Fncomms13353&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_ncomms13353
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon