Stereoselective alkoxycarbonylation of unactivated C(sp3)–H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis

• Published in: Nature communications Vol. 7; no. 1; pp. 12901 - 9
• Main Authors: Liao, Gang, Yin, Xue-Song, Chen, Kai, Zhang, Qi, Zhang, Shuo-Qing, Shi, Bing-Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.09.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/933; 639/638/549/933; 639/638/77/888; Carbon monoxide; Catalysis; Humanities and Social Sciences; Ligands; multidisciplinary; Science; Science (multidisciplinary); United States > US; California

Several examples on Pd-catalysed carbonylation of methyl C( sp 3 )–H bonds with gaseous CO via Pd(II)/Pd(0) catalysis have been reported. However, methylene C( sp 3 )–H carbonylation remains a great challenge, largely due to the lack of reactivity of C–H bonds and the difficulty in CO migratory inse...