Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology

• Published in: Cell Vol. 187; no. 8; pp. 1990 - 2009.e19
• Main Authors: Kukanja, Petra, Langseth, Christoffer M., Rubio Rodríguez-Kirby, Leslie A., Agirre, Eneritz, Zheng, Chao, Raman, Amitha, Yokota, Chika, Avenel, Christophe, Tiklová, Katarina, Guerreiro-Cacais, André O., Olsson, Tomas, Hilscher, Markus M., Nilsson, Mats, Castelo-Branco, Gonçalo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.04.2024
• Subjects: disease-associated glia; EAE; encephalomyelitis; experimental autoimmune; experimental autoimmune encephalomyelitis; in situ sequencing; multiple sclerosis; neuroinflammation; neuroinflammation disease-associated glia; neuropathology; SERPINA3; Serpina3n; single-cell; spatial sequencing; Serpina3n; SERPINA3; in situ sequencing; experimental autoimmune encephalomyelitis; disease-associated glia; neuroinflammation; multiple sclerosis; MS; single-cell; EAE; spatial sequencing; neuropathology

Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and smoldering pathology. Although single-cell analyses provided insights into cytopathology, evolving cellular processes underlying MS remain poorly understood. We investigated the cellular dynamics of MS by model...