Thiosulphate sulfurtransferase: Biological roles and therapeutic potential

• Published in: Redox biology Vol. 82; p. 103595
• Main Authors: Luo, Yang, Melhem, Shaden, Feelisch, Martin, Chatre, Laurent, Morton, Nicholas M., Dolga, Amalia M., van Goor, Harry
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025; Elsevier
• Subjects: Animals; Antioxidants - metabolism; Humans; Hydrogen Sulfide - metabolism; Life Sciences; Mitochondria - metabolism; Mitochondrial dysfunction; Oxidation-Reduction; Oxidative stress; Oxidative Stress - drug effects; Redox signaling; Review; Thiosulfate sulfurtransferase (TST); Thiosulfate Sulfurtransferase - genetics; Thiosulfate Sulfurtransferase - metabolism; Oxidative stress; Mitochondrial dysfunction; Redox signaling; Thiosulfate sulfurtransferase (TST); redox signaling; mitochondrial dysfunction; oxidative stress

Mitochondria are central to eukaryotic cell function, driving energy production, intermediary metabolism, and cellular homeostasis. Dysregulation of mitochondrial function often results in oxidative stress, a hallmark of numerous diseases, underscoring the critical need for maintaining mitochondrial...