Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter

• Published in: Biochemical journal Vol. 384; no. Pt 1; pp. 101 - 110
• Main Authors: Furihata, Tomomi, Hosokawa, Masakiyo, Satoh, Tetsuo, Chiba, Kan
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 15.11.2004
• Subjects: 5' Flanking Region - genetics; Animals; Carboxylic Ester Hydrolases - genetics; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; COS Cells - chemistry; COS Cells - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Drosophila - cytology; Drosophila - genetics; E-Box Elements - genetics; Enhancer Elements, Genetic - genetics; GC Rich Sequence - genetics; Gene Expression Profiling - methods; Gene Expression Regulation, Enzymologic - genetics; Liver Neoplasms, Experimental - genetics; Liver Neoplasms, Experimental - pathology; Male; Mice; Mice, Inbred C57BL; Microsomes - enzymology; Molecular Sequence Data; NF-kappa B - genetics; Nuclear Proteins - metabolism; Organ Specificity - genetics; Promoter Regions, Genetic - genetics; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Sp1 Transcription Factor - genetics; Sp3 Transcription Factor; Transcription Factors - genetics; Transcription Factors - physiology; Transcription Initiation Site; Transcriptional Activation - genetics; Upstream Stimulatory Factors

Mouse carboxylesterase 2 (mCES2), a microsomal acylcarnitine hydrolase, is thought to play some important roles in fatty acid (ester) metabolism, and it is therefore thought that the level of transcription of the mCES2 gene is under tight control. Examination of the tissue expression profiles reveal...