Adherent-Invasive E. coli: Update on the Lifestyle of a Troublemaker in Crohn’s Disease

• Published in: International journal of molecular sciences Vol. 21; no. 10; p. 3734
• Main Authors: Chervy, Mélissa, Barnich, Nicolas, Denizot, Jérémy
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2020; MDPI
• Subjects: Animals; Bacteria; Bacteriology; Biomarkers; Crohn Disease - metabolism; Crohn Disease - microbiology; Crohn's disease; E coli; Enteropathogenic Escherichia coli - genetics; Enteropathogenic Escherichia coli - metabolism; Enteropathogenic Escherichia coli - pathogenicity; Etiology; Gene expression; Genotype & phenotype; Host-Pathogen Interactions; Human health and pathology; Humans; Hépatology and Gastroenterology; Inflammation; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Life Sciences; Lifestyles; Microbiology and Parasitology; Microbiota; Pathogens; Phages; Review; Virulence; microbiota; AIEC-targeting therapy; adherent-invasive Escherichia coli; virulence gene; AIEC-host interaction; intestinal environment; Crohn’s disease; Crohn's disease

Besides genetic polymorphisms and environmental factors, the intestinal microbiota is an important factor in the etiology of Crohn’s disease (CD). Among microbiota alterations, a particular pathotype of Escherichia coli involved in the pathogenesis of CD abnormally colonizes the intestinal mucosa of...