Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes

• Published in: Life sciences (1973) Vol. 293; p. 120324
• Main Authors: Silva, Mauro G., Falcoff, Nora L., Corradi, Gerardo R., Alfie, José, Seguel, Rolando F., Tabaj, Gabriela C., Iglesias, Laura I., Nuñez, Myriam, Guman, Gabriela R., Gironacci, Mariela M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.03.2022; Elsevier BV
• Subjects: ACE2; Adult; Age; Age Factors; Aged; Alveolar Epithelial Cells - chemistry; Alveolar Epithelial Cells - drug effects; Alveolar Epithelial Cells - metabolism; Angiotensin; Angiotensin I - metabolism; Angiotensin II; Angiotensin II - metabolism; Angiotensin Receptor Antagonists - pharmacology; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - analysis; Angiotensin-Converting Enzyme 2 - antagonists & inhibitors; Angiotensin-Converting Enzyme 2 - metabolism; Angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Conversion; Coronaviruses; COVID-19; COVID-19 infection; Enzymes; Female; Homeostasis; Humans; Hypertension; Immunohistochemistry; Lung; Lung - chemistry; Lung - drug effects; Lung - metabolism; Lungs; Male; Middle Aged; Older people; Peptide Fragments - metabolism; Peptidyl-dipeptidase A; Pneumocytes; protein content; protein synthesis; proteinases; Proteins; Radioimmunoassay; radioimmunoassays; Receptors; Renin; renin-angiotensin system; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; Retrospective Studies; serine; Serine Endopeptidases - analysis; Serine Endopeptidases - metabolism; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Sex differences; Smoking; Smoking - metabolism; Smoking - pathology; TMPRSS2; Type II pneumocytes; Viral diseases; Hypertension; Angiotensin-converting enzyme 2; RAS; Lung; TMPRSS2; COVID-19; ACE2; SARS-CoV-2; Angiotensin; Type II pneumocytes; Ang; ARBs; ACEIs

Angiotensin-converting enzyme (ACE) 2 is the receptor for severe acute respiratory syndrome coronavirus 2 which causes coronavirus disease 2019 (COVID-19). Viral cellular entry requires ACE2 and transmembrane protease serine 2 (TMPRSS2). ACE inhibitors (ACEIs) or angiotensin (Ang) receptor blockers...