Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts

• Published in: Journal of molecular and cellular cardiology Vol. 46; no. 4; pp. 508 - 517
• Main Authors: Benamer, Najate, Moha Ou Maati, Hamid, Demolombe, Sophie, Cantereau, Anne, Delwail, Adriana, Bois, Patrick, Bescond, Jocelyn, Faivre, Jean-François
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2009; Elsevier
• Subjects: Actins - metabolism; Animals; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Cardiac fibroblasts; Cardiology and cardiovascular system; Cardiovascular; Cell Proliferation - drug effects; Cells, Cultured; Cellular Biology; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - secretion; Gene Expression Regulation - drug effects; Glyburide - pharmacology; Heart Ventricles - cytology; Heart Ventricles - metabolism; Human health and pathology; IL-6; Interleukin-6 - secretion; Ion Channel Gating - drug effects; K-channel; KATP Channels; Life Sciences; Lysophospholipids - pharmacology; Mice; Pharmaceutical sciences; Pharmacology; Pinacidil - pharmacology; Potassium Channels, Inwardly Rectifying - genetics; Potassium Channels, Inwardly Rectifying - metabolism; Protein Subunits - genetics; Protein Subunits - metabolism; Receptors, Drug - genetics; Receptors, Drug - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sphingosine - analogs & derivatives; Sphingosine - pharmacology; Sphingosine-1-phosphate; Subcellular Processes; Sulfonylurea Receptors; SUR2/Kir6.1; SUR2/Kir6.1; Cardiac fibroblasts; K-channel; IL-6; Sphingosine-1-phosphate; SUR2/Kir6.1 K-channel Cardiac fibroblasts IL-6 Sphingosine-1-phosphate

Abstract The present work is aimed at identifying and characterizing, at a molecular and functional level, new ionic conductances potentially involved in the excitation–secretion coupling and proliferation of cardiac ventricular fibroblasts. Among potassium channel transcripts which were screened by...