Synthesis and antiviral activity of a series of novel N-phenylbenzamide and N-phenylacetophenone compounds as anti-HCV and anti-EV71 agents

• Published in: Acta pharmaceutica Sinica. B Vol. 5; no. 3; pp. 201 - 209
• Main Authors: Jiang, Zhi, Wang, Huiqiang, Li, Yanping, Peng, Zonggen, Li, Yuhuan, Li, Zhuorong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.05.2015
• Subjects: Agents; Anti-EV71; Anti-HCV; N-phenylacetophenone; N-phenylbenzamide; Original; Synthesis; N-phenylacetophenone; Agents; Anti-HCV; Synthesis; N-phenylbenzamide; Anti-EV71

A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71(strain SZ-98).The biological results showed that three compounds(23,25 and 41) exhibited considerable anti-HCV activity(IC50? 0.57–7.12 μmol/L) and...