Impact of polydextrose on the faecal microbiota: a double-blind, crossover, placebo-controlled feeding study in healthy human subjects

• Published in: British journal of nutrition Vol. 108; no. 3; pp. 471 - 481
• Main Authors: Costabile, Adele, Fava, Francesca, Röytiö, Henna, Forssten, Sofia D., Olli, Kaisa, Klievink, Judith, Rowland, Ian R., Ouwehand, Arthur C., Rastall, Robert A., Gibson, Glenn R., Walton, Gemma E.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.08.2012
• Subjects: Adult; bacteria; Biological and medical sciences; butyrates; Clostridium; Clostridium - drug effects; Clostridium - growth & development; Cluster Analysis; colon; Colon - drug effects; Colon - microbiology; colorectal neoplasms; Cross-Over Studies; denaturing gradient gel electrophoresis; Denaturing Gradient Gel Electrophoresis - methods; Dietary fiber; Digestive system; Double-Blind Method; Eating - drug effects; eating habits; Enterococcus - drug effects; Enterococcus - growth & development; Feces - chemistry; Feces - microbiology; Feeding. Feeding behavior; Female; Fermentation; Fundamental and applied biological sciences. Psychology; Genotoxicity; Glucans - pharmacology; glucose; Humans; intestinal microorganisms; Lactobacillus - drug effects; Lactobacillus - growth & development; Male; Microbiology; Middle Aged; placebos; Polymerase Chain Reaction - methods; Prebiotics; Quality of life; Risk Factors; Risk reduction; Ruminococcus; Ruminococcus - drug effects; Ruminococcus - growth & development; snacks; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Polydextrose; Biomarkers of colonic health; Human faecal microbiota; Genotoxicity; Human; Feeding behavior; Healthy subject; Digestive system; Health; Gut; Biological marker; Microflora; Feeding; Vertebrata; Mammalia; Double blind study; Colon; Feces

In this placebo-controlled, double-blind, crossover human feeding study, the effects of polydextrose (PDX; 8 g/d) on the colonic microbial composition, immune parameters, bowel habits and quality of life were investigated. PDX is a complex glucose oligomer used as a sugar replacer. The main goal of...