Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1

• Published in: Frontiers in cellular neuroscience Vol. 8; p. 412
• Main Authors: Vasconcelos, Francisca F., Castro, Diogo S.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 02.12.2014; Frontiers Media S.A
• Subjects: Artificial chromosomes; ASCL1 protein; Ascl1/Mash1; Cell cycle; Cell differentiation; Cell division; Cell proliferation; Chromatin; Fibroblasts; Genomes; Neural stem cells; Neurogenesis; Neurons; Neuroscience; Neurosciences; Notch signaling; Progenitor cells; proneural gene; Proteins; Stem cells; transcription; Transcription factors; neurogenesis; Ascl1/Mash1; transcription; Notch signaling; proneural gene

Proneural transcription factors (TFs) such as Ascl1 function as master regulators of neurogenesis in vertebrates, being both necessary and sufficient for the activation of a full program of neuronal differentiation. Novel insights into the dynamics of Ascl1 expression at the cellular level, combined...