Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

• Published in: Nature biotechnology Vol. 41; no. 1; pp. 70 - 81
• Main Authors: Rafat, Mehrdad, Jabbarvand, Mahmoud, Sharma, Namrata, Xeroudaki, Maria, Tabe, Shideh, Omrani, Raha, Thangavelu, Muthukumar, Mukwaya, Anthony, Fagerholm, Per, Lennikov, Anton, Askarizadeh, Farshad, Lagali, Neil
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2023; Nature Publishing Group
• Subjects: 631/61/2035; 631/61/54/990; 631/61/54/993; 692/308/575; Acuity; Agriculture; Animals; Bioengineering; Bioinformatics; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Blindness; Collagen; Contact lenses; Cornea; Corneal Topography; Eye diseases; Feasibility studies; Follow-Up Studies; Immunological tolerance; Keratoconus; Keratoconus - surgery; Life Sciences; Prospective Studies; Refraction, Ocular; Stroma; Swine; Tissue Engineering; Translational Research, Biomedical; Transplantation; Vision; Visual acuity; Iran; India

Visual impairment from corneal stromal disease affects millions worldwide. We describe a cell-free engineered corneal tissue, bioengineered porcine construct, double crosslinked (BPCDX) and a minimally invasive surgical method for its implantation. In a pilot feasibility study in India and Iran (cli...