A novel algorithm to predict bone changes in the mouse tibia properties under physiological conditions

• Published in: Biomechanics and modeling in mechanobiology Vol. 19; no. 3; pp. 985 - 1001
• Main Authors: Cheong, Vee San, Campos Marin, Ana, Lacroix, Damien, Dall’Ara, Enrico
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2020
• Subjects: Algorithms; Animals; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biophysics; Bone and Bones; Bone Remodeling; Bone Resorption; Cluster Analysis; Densitometry; Engineering; Female; Finite Element Analysis; Mice; Mice, Inbred C57BL; Original Paper; Stress, Mechanical; Theoretical and Applied Mechanics; Tibia - physiology; Weight-Bearing; X-Ray Microtomography; Bone adaptation; In silico simulation; Validation; Finite element analysis; Bone remodelling; In vivo micro-computed tomography

Understanding how bone adapts to mechanical stimuli is fundamental for optimising treatments against musculoskeletal diseases in preclinical studies, but the contribution of physiological loading to bone adaptation in mouse tibia has not been quantified so far. In this study, a novel mechanistic mod...