Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis

• Published in: Critical reviews in biochemistry and molecular biology Vol. 54; no. 2; pp. 184 - 192
• Main Authors: Cantorna, Margherita T., Snyder, Lindsay, Arora, Juhi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.03.2019
• Subjects: Animals; diet; digestive tract; Gastrointestinal Microbiome; gastrointestinal tract; Homeostasis; Humans; Immunity, Mucosal; interleukin-17; intestinal microorganisms; intestinal mucosa; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; microbiota; molecular biology; mucosal immune system; mucosal immunity; nutrition; tight junctions; Vitamin A; Vitamin A - immunology; vitamin D; Vitamin D - immunology; microbiota; mucosal immune system; Vitamin A; nutrition; gastrointestinal tract; vitamin D

Diet is an important regulator of the gastrointestinal microbiota. Vitamin A and vitamin D deficiencies result in less diverse, dysbiotic microbial communities and increased susceptibility to infection or injury of the gastrointestinal tract. The vitamin A and vitamin D receptors are nuclear recepto...