Tc1/Tc2 and Th1/Th2 balance in Asian and Western types of multiple sclerosis, HTLV-I-associated myelopathy/tropical spastic paraparesis and hyperIgEaemic myelitis

• Published in: Journal of neuroimmunology Vol. 119; no. 2; pp. 297 - 305
• Main Authors: Ochi, Hirofumi, Wu, Xiao-Mu, Osoegawa, Manabu, Horiuchi, Izumi, Minohara, Motozumi, Murai, Hiroyuki, Ohyagi, Yasumasa, Furuya, Hirokazu, Kira, Jun-ichi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2001
• Subjects: Adult; Aged; Asian Continental Ancestry Group; CD4 antigen; CD8 antigen; European Continental Ancestry Group; Flow Cytometry; g-Interferon; HTLV-I-associated myelopathy; Human T-lymphotropic virus 1; Humans; Immunoglobulin E - immunology; Middle Aged; Multiple sclerosis; Multiple Sclerosis - ethnology; Multiple Sclerosis - immunology; Myelitis; Myelitis - ethnology; Myelitis - immunology; Paraparesis, Tropical Spastic - ethnology; Paraparesis, Tropical Spastic - immunology; T-Lymphocytes - immunology; T-Lymphocytes, Cytotoxic - immunology; Tc1/Tc2; Th1 Cells - immunology; Th1/Th2; Th2 Cells - immunology; Th1/Th2; Myelitis; Multiple sclerosis; Tc1/Tc2; HTLV-I-associated myelopathy

CD8 + T cells, like CD4 + T cells, can differentiate into at least two subsets with distinct cytokine patterns: Tc1 cells produce Th1-like cytokines and Tc2 cells produce Th2-like cytokines. To clarify the immunopathological roles of Tc1 and Tc2 cells in central nervous system (CNS) inflammation, we...