Long Noncoding RNAs: Cellular Address Codes in Development and Disease

In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code—how objects are placed and later searched for and retrieved. Long noncoding...

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Bibliographic Details
Published inCell Vol. 152; no. 6; pp. 1298 - 1307
Main Authors Batista, Pedro J., Chang, Howard Y.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 14.03.2013
Subjects
Animals
Cell Nucleus - chemistry
Cell Nucleus - genetics
chromosome translocation
chromosomes
Disease - genetics
Gene Expression Regulation
genes
Humans
non-coding RNA
RNA, Long Noncoding - chemistry
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
traffic
translocation
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Summary:In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code—how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. lncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.
Bibliography:http://dx.doi.org/10.1016/j.cell.2013.02.012
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ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2013.02.012