Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

• Published in: Neurobiology of disease Vol. 169; p. 105739
• Main Authors: Duan, Na, Zhang, Yanpeng, Tan, Shuwen, Sun, Jianyu, Ye, Mao, Gao, Hui, Pu, Kairui, Wu, Meiyan, Wang, Qiang, Zhai, Qian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2022; Elsevier
• Subjects: Animals; Chronic stress; Cytokines - metabolism; Depression - drug therapy; Depression - etiology; Interferon; Interferon Regulatory Factor-3 - metabolism; Interferon Regulatory Factor-3 - pharmacology; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; Neuroinflammation; Neuroinflammatory Diseases; Phagocytosis; Protein Serine-Threonine Kinases; Neuroinflammation; Chronic stress; Interferon; Phagocytosis; Microglia

Stress is well known to contribute to the development of both neurological and psychiatric diseases. In the central nervous system, a role for STING (stimulator of interferon genes) in modulating immunological responses has been widely suggested, and this protein possesses both neurotoxic and neurop...