CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

• Published in: Nature communications Vol. 7; no. 1; pp. 11687 - 11
• Main Authors: Cao, Wenqiang, Guo, Jing, Wen, Xiaofeng, Miao, Li, Lin, Feng, Xu, Guanxin, Ma, Ruoyu, Yin, Shengxia, Hui, Zhaoyuan, Chen, Tingting, Guo, Shixin, Chen, Wei, Huang, Yingying, Liu, Yizhi, Wang, Jianli, Wei, Lai, Wang, Lie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.05.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/1619/554; 631/250/1620/1840; 631/250/516; 631/337/458/1648; Animals; Binding sites; CD8 Antigens - metabolism; Cell Line; Cell Survival; DNA methylation; Epigenesis, Genetic; Epigenetics; Gene expression; Genomes; Histones - metabolism; Humanities and Social Sciences; Immunology; Mice; Mice, Knockout; multidisciplinary; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Proteins; Receptors, Antigen, T-Cell - metabolism; Science; Science (multidisciplinary); Thymocytes - physiology; Thymus gland; Trans-Activators - physiology; ZAP-70 Protein-Tyrosine Kinase - metabolism; Pittsburgh Pennsylvania; United States > US; China; Pennsylvania

T-cell development in the thymus is largely controlled by an epigenetic program, involving in both DNA methylation and histone modifications. Previous studies have identified Cxxc1 as a regulator of both cytosine methylation and histone 3 lysine 4 trimethylation (H3K4me3). However, it is unknown whe...