Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle

• Published in: Journal of applied physiology (1985) Vol. 99; no. 4; pp. 1247 - 1253
• Main Authors: Magalhaes, Jose, Ascensao, Antonio, Soares, Jose M. C, Ferreira, Rita, Neuparth, Maria J, Marques, Franklim, Duarte, Jose A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.10.2005; American Physiological Society
• Subjects: Acute Disease; Animals; Atmospheric Pressure; Biological and medical sciences; Carbonyl compounds; Fundamental and applied biological sciences. Psychology; Hypoxia; Hypoxia - etiology; Hypoxia - metabolism; Hypoxia - physiopathology; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitochondria, Muscle - metabolism; Mitochondrial DNA; Muscle, Skeletal - metabolism; Muscular system; Oxidation; Oxidative Stress; Oxygen Consumption - drug effects; Respiration; Respiratory function; Rodents; Severity of Illness Index; Superoxides - metabolism; Vitamin E - metabolism; Vitamin E - pharmacology; High altitude; Oxidative stress; Oxygen; antioxidants; Acute; Rodentia; vitamin E; Environmental factor; oxidative damage; E-Vitamins; Antioxidant; Striated muscle; Vertebrata; Mitochondria; Mammalia; Mouse; Heat shock protein; Hypoxia; heat shock proteins

1 Department of Sport Biology, Faculty of Sport Science, and 2 Department of Clinical Analysis and of Biochemistry, Faculty of Pharmacy, Institute for Molecular and Cell Biology University of Porto, Porto, Portugal Submitted 24 November 2004 ; accepted in final form 11 May 2005 ABSTRACT Severe high-...