Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients

• Published in: Scientific reports Vol. 8; no. 1; pp. 12247 - 8
• Main Authors: Ezzikouri, Sayeh, Elfihry, Raouia, Chihab, Hajar, Elmessaoudi-Idrissi, Mohcine, Zaidane, Imane, Jadid, Fatima Zahra, Karami, Adnane, Tahiri, Mohamed, Elhabazi, Abdellah, Kabine, Mostafa, Chair, Mohammed, Pineau, Pascal, Benjelloun, Soumaya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.08.2018; Nature Publishing Group
• Subjects: 45/56; 45/77; 631/208; 692/53/2421; Acyltransferase; Acyltransferases - genetics; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Disease Progression; Female; Fibrosis; Gene Frequency; Gene polymorphism; Genetic diversity; Genetic factors; Genetics; Genotype; Hepatitis; Hepatitis B; Hepatitis B, Chronic - genetics; Hepatitis B, Chronic - pathology; Hepatitis C; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - pathology; Human genetics; Human health and pathology; Humanities and Social Sciences; Humans; Hépatology and Gastroenterology; Infections; Infectious diseases; Interferon; Life Sciences; Liver diseases; Male; Membrane proteins; Membrane Proteins - genetics; Microbiology and Parasitology; Middle Aged; Morocco; multidisciplinary; Polymorphism, Single Nucleotide; Regression analysis; Science; Science (multidisciplinary); Virology; Young Adult; Morocco

The outcomes of HBV and HCV infections are associated both with viral and host genetic factors. Here, we explore the role of a genetic variation located in membrane-bound O-acyltransferase domain-containing protein 7 ( MBOAT7) gene on spontaneous clearance of HBV and HCV infections and on liver fibr...