Novel signaling axis for ROS generation during K-Ras-induced cellular transformation

• Published in: Cell death and differentiation Vol. 21; no. 8; pp. 1185 - 1197
• Main Authors: Park, M-T, Kim, M-J, Suh, Y, Kim, R-K, Kim, H, Lim, E-J, Yoo, K-C, Lee, G-H, Kim, Y-H, Hwang, S-G, Yi, J-M, Lee, S-J
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.08.2014
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Biochemistry; Cancer; Cell death; Cell Line, Tumor; Cell Transformation, Neoplastic - metabolism; Enzymes; Fibroblasts - metabolism; Heterografts; Kinases; Life sciences; NADH, NADPH Oxidoreductases - metabolism; NADPH Oxidase 1; NADPH Oxidases - metabolism; Nuclear Proteins - metabolism; Original Paper; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Proteins; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins p21(ras) - metabolism; Radiation; ras Proteins - metabolism; Rats; Reactive Oxygen Species - metabolism; Signal Transduction; Transfection

Reactive oxygen species (ROS) are well known to be involved in oncogene-mediated cellular transformation. However, the regulatory mechanisms underlying ROS generation in oncogene-transformed cells are unclear. In the present study, we found that oncogenic K-Ras induces ROS generation through activat...