Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54...

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Published inNature communications Vol. 11; no. 1; p. 5243
Main Authors Carissimo, Guillaume, Xu, Weili, Kwok, Immanuel, Abdad, Mohammad Yazid, Chan, Yi-Hao, Fong, Siew-Wai, Puan, Kia Joo, Lee, Cheryl Yi-Pin, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Chee, Rhonda Sin-Ling, How, Wilson, Chan, Stephrene, Fan, Bingwen Eugene, Andiappan, Anand Kumar, Lee, Bernett, Rötzschke, Olaf, Young, Barnaby Edward, Leo, Yee-Sin, Lye, David Chien, Renia, Laurent, Ng, Lai Guan, Larbi, Anis, Ng, Lisa FP
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.10.2020
Nature Portfolio
Subjects
13/21
13/31
631/250/127
631/250/2520
631/250/255
631/326/596/4130
Betacoronavirus - immunology
Biomarkers - blood
CD8-Positive T-Lymphocytes - immunology
Coronavirus Infections - immunology
Coronavirus Infections - pathology
COVID-19
Cytokine Release Syndrome - immunology
Cytokine Release Syndrome - pathology
Flow Cytometry
Humanities and Social Sciences
Humans
Immunophenotyping - methods
Interleukin-10 - blood
Interleukin-6 - blood
Lymphocyte Count
multidisciplinary
Neutrophils - immunology
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Receptors, Antigen, T-Cell, gamma-delta - immunology
SARS-CoV-2
Science
Science (multidisciplinary)
Severity of Illness Index
Online AccessGet full text

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Abstract SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management. COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.
AbstractList COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.
SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management. COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.
SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management.
ArticleNumber 5243
Author Larbi, Anis
Chan, Yi-Hao
Amrun, Siti Naqiah
Andiappan, Anand Kumar
Fan, Bingwen Eugene
Ng, Lai Guan
Lee, Bernett
Rötzschke, Olaf
Abdad, Mohammad Yazid
Puan, Kia Joo
Young, Barnaby Edward
Xu, Weili
Renia, Laurent
Yeo, Nicholas Kim-Wah
Kwok, Immanuel
Fong, Siew-Wai
Lye, David Chien
How, Wilson
Chan, Stephrene
Ng, Lisa FP
Carissimo, Guillaume
Leo, Yee-Sin
Lee, Cheryl Yi-Pin
Chee, Rhonda Sin-Ling
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SSID ssj0000391844
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Snippet SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected...
COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors...
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SubjectTerms 13/21
13/31
631/250/127
631/250/2520
631/250/255
631/326/596/4130
Betacoronavirus - immunology
Biomarkers - blood
CD8-Positive T-Lymphocytes - immunology
Coronavirus Infections - immunology
Coronavirus Infections - pathology
COVID-19
Cytokine Release Syndrome - immunology
Cytokine Release Syndrome - pathology
Flow Cytometry
Humanities and Social Sciences
Humans
Immunophenotyping - methods
Interleukin-10 - blood
Interleukin-6 - blood
Lymphocyte Count
multidisciplinary
Neutrophils - immunology
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Receptors, Antigen, T-Cell, gamma-delta - immunology
SARS-CoV-2
Science
Science (multidisciplinary)
Severity of Illness Index
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Title Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19
URI https://link.springer.com/article/10.1038/s41467-020-19080-6
https://www.ncbi.nlm.nih.gov/pubmed/33067472
https://search.proquest.com/docview/2451849252
https://pubmed.ncbi.nlm.nih.gov/PMC7568554
https://doaj.org/article/d967340f6639442885027de8b53a2e43
Volume 11
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