Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors

• Published in: Bioorganic & medicinal chemistry letters Vol. 23; no. 21; pp. 5836 - 5839
• Main Authors: Li, Wei, Li, Songpei, Higai, Koji, Sasaki, Tatsunori, Asada, Yoshihisa, Ohshima, Shigeru, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2013
• Subjects: AKT protein; carcinogenesis; diabetes; drugs; Flavonoids; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Glycyrrhiza; Glycyrrhiza - chemistry; Glycyrrhiza glabra; Hep G2 Cells; Humans; Insulin - metabolism; Licorice; obesity; phosphorylation; Phosphorylation - drug effects; Protein tyrosine phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism; protein-tyrosine-phosphatase; Proto-Oncogene Proteins c-akt - metabolism; screening; Protein tyrosine phosphatase 1B; Flavonoids; Licorice; Glycyrrhiza

Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator in insulin- and leptin-signaling cascades as well as a positive regulator in tumorigenesis, and much attention has been paid to PTP1B inhibitors as potential therapies for diabetes, obesity, and cancer. In the present study, the s...