Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease

• Published in: Neurobiology of disease Vol. 193; p. 106438
• Main Authors: Vidas-Guscic, Nicholas, van Rijswijk, Joëlle, Van Audekerke, Johan, Jeurissen, Ben, Nnah, Israel, Tang, Haiying, Muñoz-Sanjuan, Ignacio, Pustina, Dorian, Cachope, Roger, Van der Linden, Annemie, Bertoglio, Daniele, Verhoye, Marleen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2024; Elsevier
• Subjects: Animals; Biomarkers; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Disease Models, Animal; Fixel-based analysis; Humans; Huntington Disease - diagnostic imaging; Huntington Disease - genetics; Huntington's disease; Longitudinal; Mice; Neurodegeneration; Neurodegenerative Diseases; Neurofilament; Preclinical; White Matter - diagnostic imaging; Neurofilament; Longitudinal; Preclinical; Huntington's disease; Neurodegeneration; Fixel-based analysis

Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD. The identification of sensitive white-matter-based biomarkers in HD animal models will...