Effects of recombinant human growth hormone in the treatment of dwarfism and relationship between IGF-1, IGFBP-3 and thyroid hormone

• Published in: Experimental and therapeutic medicine Vol. 12; no. 6; pp. 3579 - 3582
• Main Authors: Ren, Shanxiang, Nie, Yuxiang, Wang, Aihong
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Care and treatment; Carrier proteins; Development and progression; Drug dosages; Dwarfism; Genetic aspects; growth hormone deficiency; Growth hormones; Health aspects; idiopathic short stature; Insulin; insulin-like growth factor-1; insulin-like growth factor-binding protein-3; Insulin-like growth factors; Metabolism; Proteins; recombinant human growth hormone; Recombinant molecules; Somatotropin; Thyroid gland; thyroid hormone; Thyroid hormones; China; thyroid hormone; insulin-like growth factor-binding protein-3; dwarfism; idiopathic short stature; insulin-like growth factor-1; recombinant human growth hormone; growth hormone deficiency
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2016.3831

The effects of recombinant human growth hormone (rhGH) in the treatment of dwarfism and the relationship between insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3 and thyroid hormone were examined in the present study. For this purpose, 66 patients diagnosed with dwarfism were selected retrospectively, with 36 cases of growth hormone deficiency (GHD) and 30 cases of idiopathic short stature (ISS). The therapeutic dose of GHD 0.10 IU/kg·day and ISS 0.15 IU/kg·day were injected subcutaneously every night before sleep until adulthood. The average follow-up was 5 years, and the results were evaluated and measured every 3 months, including height, BA, secondary test of growth hormone (GH peak), IGF-1, IGFBP-3 and thyroid hormone (FT3, FT4 and TSH). After treatment, the height, BA, GH peak, IGF-A and IGFBP-3 of the GHD group were all increased, and the differences were statistically significant (P<0.05), while FT3, FT4 and TSH had no significant change (P<0.05). The height and BA increased and the differences were statistically significant (P<0.05). The indexes of the ISS group were not statistically significant (P>0.05). The results of the Pearson-related analysis suggested that GH peak of the GHD group, IGF-1 and IGFBP-3 were positively associated with height (P<0.05), and had no relationship with BA (P<0.05). None of the above indexes of the ISS group had an obvious correlation with height and BA (P>0.05). rhGH was effective for GHD and ISS, with the GHD effect being positively associated with the GH peak, IGF-1 and IGFBP-3. ISS had no obvious relationship with GH peak, IGF-1 and IGFBP-3 although other influencing factors may be involved.