Systematic analysis of natural antibody responses to P. falciparum merozoite antigens by protein arrays

• Published in: Journal of proteomics Vol. 78; no. 14; pp. 148 - 158
• Main Authors: Fan, Yan-Ting, Wang, Yue, Ju, Chuan, Zhang, Ting, Xu, Bin, Hu, Wei, Chen, Jun-Hu
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 14.01.2013; Elsevier
• Subjects: Adolescent; Adult; Antibodies, Protozoan; Antibodies, Protozoan - blood; Antibodies, Protozoan - immunology; antibody formation; Antibody response; Antigen; antigens; Antigens, Protozoan; Antigens, Protozoan - blood; Antigens, Protozoan - immunology; Biological and medical sciences; blood; blood serum; cell free system; Diverse techniques; Female; Fundamental and applied biological sciences. Psychology; genes; Humans; immunology; malaria; Malaria, Falciparum; Malaria, Falciparum - blood; Malaria, Falciparum - immunology; Male; Merozoite; merozoites; Merozoites - immunology; Merozoites - metabolism; metabolism; methods; Middle Aged; Molecular and cellular biology; Plasmodium falciparum; Plasmodium falciparum - immunology; Plasmodium falciparum - metabolism; Protein array; Protein Array Analysis; Protein Array Analysis - methods; proteins; proteome; screening; transcriptome; vaccine development; wheat germ; Antigen; Plasmodium falciparum; Protein array; Merozoite; Antibody response; Protozoa; Apicomplexa; Antibody; Analysis; Protein microarray

With the completion of the functional genome, merozoite proteome and stage-specific transcriptomes of the intraerythrocytic developmental cycle of Plasmoidum falciparum, the development of new vaccine candidates targeting Plasmodium merozoites is now possible. Here we report using protein array tech...