Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis

• Published in: Psychological medicine Vol. 42; no. 10; pp. 2015 - 2026
• Main Authors: Hiles, S. A., Baker, A. L., de Malmanche, T., Attia, J.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2012
• Subjects: Adult and adolescent clinical studies; Age; Antidepressant drugs; Antidepressants; Antidepressive Agents - blood; Antidepressive Agents - therapeutic use; Anxiety; Biological and medical sciences; C-Reactive Protein; Clinical outcomes; Cross-Sectional Studies; Cytokines; Depression; Depressive Disorder - blood; Depressive Disorder - complications; Heterogeneity; Humans; Inflammation - blood; Inflammation - complications; Interleukin-10 - blood; Interleukin-6 - blood; Medical sciences; Mental depression; Meta-analysis; Mood disorders; Neuropharmacology; Pharmacology. Drug treatments; Proteins; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Systematic review; Weight gain; meta-analysis; C-reactive protein; depression; interleukin; systematic review; inflammation; Mood disorder; Psychotropic; Cytokine; Depression; Inflammation; Review; Metaanalysis; Interleukin 6; Treatment; Interleukin 10; Antidepressant agent; C reactive protein

Cross-sectional studies support an association between depression and inflammatory markers. However, little is known of their relationship in the context of antidepressant treatment. Our aim was to explore via meta-analysis whether antidepressant treatment is associated with a reduction in three inf...