Functions of Thrombospondin-1 in the Tumor Microenvironment

• Published in: International journal of molecular sciences Vol. 22; no. 9; p. 4570
• Main Authors: Kaur, Sukhbir, Bronson, Steven M, Pal-Nath, Dipasmita, Miller, Thomas W, Soto-Pantoja, David R, Roberts, David D
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2021; MDPI
• Subjects: Adhesion; Angiogenesis; Angiogenesis inhibitors; Animals; Autophagy; Binding sites; Breast cancer; Cancer; Carcinogenesis; Carcinogens; CD36; CD47; Cell Adhesion; Cell Movement; Cell surface; Chemotherapy; cytotoxic T cells; Extracellular vesicles; Fibroblasts; Gene expression; Genotoxicity; Growth factors; Humans; Immune system; integrins; Integrins - metabolism; Ischemia; Life Sciences; Low density lipoprotein receptors; Lymphocytes; Melanoma; Metabolic response; Metastases; Metastasis; Mice; Motility; mRNA; natural killer cells; Neoplasms - blood supply; Neoplasms - immunology; Neoplasms - pathology; Neovascularization, Pathologic - metabolism; Neovascularization, Physiologic - genetics; Peptides; Perfusion; Phagocytosis; Proteins; Radiation therapy; Review; Senescence; Stem cells; T-Lymphocytes - immunology; Therapeutic targets; Thrombospondin; Thrombospondin 1 - genetics; Thrombospondin 1 - metabolism; Thrombospondin 1 - physiology; Tumor microenvironment; Tumor Microenvironment - physiology; Tumor suppressor genes; natural killer cells; integrins; nitric oxide; autophagy; angiogenesis; transforming growth factor-β1; tumor-initiating cells; CD36; CD47; cytotoxic T cells

The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. Decreased thrombospondin-1 mRNA and protein expression are associated with progression in several cancers, while expression by nonmaligna...