Protein kinase D at the Golgi controls NLRP3 inflammasome activation

• Published in: The Journal of experimental medicine Vol. 214; no. 9; pp. 2671 - 2693
• Main Authors: Zhang, Zhirong, Meszaros, Gergö, He, Wan-ting, Xu, Yanfang, de Fatima Magliarelli, Helena, Mailly, Laurent, Mihlan, Michael, Liu, Yansheng, Puig Gámez, Marta, Goginashvili, Alexander, Pasquier, Adrien, Bielska, Olga, Neven, Bénédicte, Quartier, Pierre, Aebersold, Rudolf, Baumert, Thomas F., Georgel, Philippe, Han, Jiahuai, Ricci, Romeo
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.09.2017; The Rockefeller University Press
• Subjects: Activation; Animals; Assembly; Cytosol; Deactivation; Diglycerides; Diglycerides - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum - physiology; Golgi apparatus; Golgi Apparatus - physiology; Hazards; Humans; Immune response; Inactivation; Inflammasomes; Inflammasomes - physiology; Innate immunity; Kinases; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Membranes; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mutation; NLR Family, Pyrin Domain-Containing 3 Protein - physiology; Oligomerization; Peripheral blood mononuclear cells; Phosphorylation; Protein kinase; Protein Kinase C - physiology; Proteins; Signaling

The inflammasomes are multiprotein complexes sensing tissue damage and infectious agents to initiate innate immune responses. Different inflammasomes containing distinct sensor molecules exist. The NLRP3 inflammasome is unique as it detects a variety of danger signals. It has been reported that NLRP...