Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality

• Published in: Inflammation research Vol. 69; no. 11; pp. 1077 - 1085
• Main Author: Shenoy, Santosh
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2020
• Subjects: Aging; Allergology; Biomedical and Life Sciences; Biomedicine; Coronavirus Infections - complications; Coronavirus Infections - mortality; Coronavirus Infections - pathology; COVID-19; Dermatology; Humans; Immunology; Inflammation - etiology; Inflammation - mortality; Inflammation - pathology; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Diseases - etiology; Mitochondrial Diseases - mortality; Mitochondrial Diseases - pathology; Neurology; Pandemics; Pharmacology/Toxicology; Pneumonia, Viral - complications; Pneumonia, Viral - mortality; Pneumonia, Viral - pathology; Review; Rheumatology; Sepsis - etiology; Sepsis - mortality; Sepsis - pathology; Sirtuins; HIF-α; Mitochondrial dysfunction; Covid-19; Viral replication; DAMP

Background Decline in mitochondrial function occurs with aging and may increase mortality. We discuss mitochondrial contribution to Covid-19 sepsis, specifically the complex interaction of innate immune function, viral replication, hyper-inflammatory state, and HIF-α/Sirtuin pathways. Methods Articl...