The influence of plasma glucose concentrations on ischemic brain damage is a threshold function

• Published in: Neuroscience Letters Vol. 177; no. 1; pp. 63 - 65
• Main Authors: Li, Ping-An, Shamloo, Mehrdad, Smith, Maj-Lis, Katsura, Ken-ichiro, Siesjö, Bo K
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.08.1994; Elsevier BV; Elsevier
• Subjects: Animals; Biological and medical sciences; Blood Glucose; Blood Glucose - physiology; Brain damage; Brain Ischemia; Brain Ischemia - blood; Brain Ischemia - complications; Brain Ischemia - pathology; Gyrus Cinguli; Gyrus Cinguli - pathology; Hippocampus; Hippocampus - pathology; Histopathology; Hydrogen-Ion Concentration; Hyperglycemia; Hyperglycemia - complications; Ischemia; Male; Medical sciences; Neurology; Rat; Rats; Rats, Wistar; Seizure; Seizures; Seizures - blood; Seizures - etiology; Seizures - pathology; Specific Pathogen-Free Organisms; Status Epilepticus; Status Epilepticus - blood; Status Epilepticus - etiology; Status Epilepticus - pathology; Substantia Nigra; Substantia Nigra - pathology; Thalamic Nuclei; Thalamic Nuclei - pathology; Vascular diseases and vascular malformations of the nervous system; Brain damage; Hyperglycemia; Seizure; Histopathology; Ischemia; Rat; Nervous system diseases; Epilepsy; Rodentia; Glucose; Pathology; Vertebrata; Mammalia; Convulsion; Central nervous system disease; Cerebrovascular disease; Glycemia; Brain (vertebrata)

To investigate whether aggravation of damage in hyperglycemic subjects is a continuous function of changes in intra- and extracellular pH during ischemia or whether there is a threshold value, preischemic plasma glucose was varied from 8.3–20.0 mM. 10 min forebrain ischemia was induced. The results...