Sex Hormone-Binding Globulin, Oligomenorrhea, Polycystic Ovary Syndrome, and Childhood Insulin at Age 14 Years Predict Metabolic Syndrome and Class III Obesity at Age 24 Years

• Published in: The Journal of pediatrics Vol. 159; no. 2; pp. 308 - 313.e2
• Main Authors: Glueck, Charles J., MD, Morrison, John A., PhD, Daniels, Stephen, MD, PhD, Wang, Ping, PhD, Stroop, Davis, MSc
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Elsevier Inc 01.08.2011; Mosby, Inc; Elsevier
• Subjects: Adolescent; adulthood; animal ovaries; Biological and medical sciences; Biomarkers - blood; Body Mass Index; Child; childhood; Disease Progression; Female; Female genital diseases; Follow-Up Studies; General aspects; girls; Gynecology. Andrology. Obstetrics; Humans; Hyperaldosteronism - blood; Hyperaldosteronism - complications; Hyperaldosteronism - epidemiology; hyperandrogenism; Incidence; insulin; Insulin - blood; Insulin Resistance; Medical sciences; Metabolic diseases; metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Miscellaneous; Non tumoral diseases; obesity; Obesity, Morbid - blood; Obesity, Morbid - epidemiology; Obesity, Morbid - etiology; Oligomenorrhea - blood; Oligomenorrhea - complications; Oligomenorrhea - epidemiology; Other metabolic disorders; Pediatrics; periodicity; polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - epidemiology; Prospective Studies; Radioimmunoassay; ROC Curve; Sex Hormone-Binding Globulin - metabolism; Time Factors; United States - epidemiology; Young Adult; NGHS; Polycystic ovary syndrome; Sex hormone-binding globulin; Metabolic syndrome; E2; Estradiol; AUC; Body mass index; HDL; Area under the receiver operating characteristic curve; PCOS; DHEAS; Dehydroepiandrosterone sulfate; MetS; High-density lipoprotein; National Growth and Health Study; SHBG; BMI; Endocrinopathy; Human; Obesity; Pediatrics; Pancreatic hormone; Menstruation disorders; Nutrition disorder; Prediction; Sex hormone binding protein; Metabolic diseases; Cardiovascular disease; Female sterility; Oligomenorrhea; Polycystic ovary; Insulin; Female genital diseases; Ovarian diseases; Cyst; Benign neoplasm; Predictive factor; Child; Age; Nutritional status

Objective We hypothesized that oligomenorrhea (menstrual cyclicity ≥42 days), hyperandrogenism, low levels of sex hormone-binding globulin (SHBG), childhood insulin, and metabolic syndrome (MetS) at age 14 years would predict MetS and class III obesity (body mass index ≥40 kg/m2 ) at age 24 years. S...