The Centriolar Adjunct–Appearance and Disassembly in Spermiogenesis and the Potential Impact on Fertility

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 2; pp. 180 - 11
• Main Authors: Garanina, Anastasiia S., Alieva, Irina B., Bragina, Elizaveta E., Blanchard, Emmanuelle, Arbeille, Brigitte, Guerif, Fabrice, Uzbekova, Svetlana, Uzbekov, Rustem E.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.02.2019; MDPI
• Subjects: Adult; Animals; centriolar adjunct; centriole; Centrioles - metabolism; Centrioles - ultrastructure; centrosome; Chromatin; Chromatin - metabolism; Computer Science; Ethanol; Fertility; Fertility - physiology; human spermatozoa ultrastructure; Humans; idiopathic male sterility (IMS); In vitro fertilization; in vitro fertilization (IVF); Infertility; Infertility, Male - pathology; Laboratory animals; Life Sciences; Male; Male sterility; Morphology; Patients; Sperm; Spermatids; Spermatids - metabolism; Spermatids - ultrastructure; Spermatogenesis - physiology; Spermiogenesis; Statistical analysis; Swine; Tissue Donors; Transmission electron microscopy; Zygotes; France; United States > US; Germany; idiopathic male sterility (IMS); human spermatozoa ultrastructure; centriolar adjunct; centriole; centrosome; in vitro fertilization (IVF)

During spermiogenesis, the proximal centriole forms a special microtubular structure: the centriolar adjunct. This structure appears at the spermatid stage, which is characterized by a condensed chromatin nucleus. We showed that the centriolar adjunct disappears completely in mature porcine spermato...