Akt Inhibition as Preconditioning Treatment to Protect Kidney Cells against Anoxia

• Published in: International journal of molecular sciences Vol. 23; no. 1; p. 152
• Main Authors: Melis, Nicolas, Carcy, Romain, Rubera, Isabelle, Cougnon, Marc, Duranton, Christophe, Tauc, Michel, Pisani, Didier F
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2022; MDPI
• Subjects: AKT protein; Animals; Anoxia; Antioxidants; Antioxidants - pharmacology; Apoptosis; Cells, Cultured; eIF5A; GC7; Glucose; Glucose metabolism; Glycolysis; Hypoxia; Hypoxia - drug therapy; Hypoxia - metabolism; Immunological tolerance; Ischemia; Ischemic Preconditioning - methods; Kidney - drug effects; Kidney - metabolism; Kidneys; Kinases; Life Sciences; Mammals; Metabolism; Methacrylates - pharmacology; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Nutrients; Organs; Oxidative phosphorylation; Oxidative stress; Oxygen demand; Phosphorylation; Phosphorylation - drug effects; Polyamines; Preconditioning; Protective Agents - pharmacology; Protein Kinase Inhibitors - pharmacology; Proteins; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Reperfusion; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; ROS; Thiazoles - pharmacology; Transcription factors; Transplants; Transplants & implants; triciribine; triciribine; GC7; mitochondria; ROS; eIF5A; ischemia

Lesions issued from the ischemia/reperfusion (I/R) stress are a major challenge in human pathophysiology. Of human organs, the kidney is highly sensitive to I/R because of its high oxygen demand and poor regenerative capacity. Previous studies have shown that targeting the hypusination pathway of eI...