Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity - Li, Chia-Wei; Lim, Seung-Oe; Xia, Weiya; Lee, Heng-Huan; Chan, Li-Chuan; Kuo, Chu-Wei; Khoo, Kay-Hooi; Chang, Shih-Shin; Cha, Jong-Ho; Kim, Taewan; Hsu, Jennifer L.; Wu, Yun; et al. (Nature communications, 2016)
Keywords: 13/106; 14/1; 38/70; 631/250/580; 631/67/1059/2325; 631/67/1347; 631/80/458/1524; 64; 64/60; 82/58; Animal models; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; B7-H1 Antigen - immunology; B7-H1 Antigen - metabolism; beta-Transducin Repeat-Containing Proteins - metabolism; Breast - pathology; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Cancer; Cell death; Cell Line, Tumor; Deactivation; Epidermal growth factor; Epidermal Growth Factor - metabolism; Female; Gefitinib; Glycogen; Glycogen synthase kinase 3; Glycogen Synthase Kinase 3 beta - metabolism; Glycosylation; Growth factors; Humanities and Social Sciences; Humans; Immunity; Immunologic Surveillance - immunology; Immunosuppression; Inactivation; Kinases; Ligands; Lymphocyte Activation - immunology; Lymphocytes T; Mice; Mice, Inbred BALB C; Mortality; multidisciplinary; PD-1 protein; PD-L1 protein; Phosphorylation; Programmed Cell Death 1 Receptor - metabolism; Proteasomes; Protein Stability - drug effects; Proteins; Quinazolines - pharmacology; Quinazolines - therapeutic use; Science; Science (multidisciplinary); Signal transduction; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor Escape - immunology; Tumors; Ubiquitination; Xenograft Model Antitumor Assays