Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N -glycosylation. We show that glycogen sy...
Saved in:
| Published in | Nature communications Vol. 7; no. 1; pp. 12632 - 11 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
30.08.2016
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and
N
-glycosylation. We show that glycogen synthase kinase 3β (GSK3β) interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. In-depth analysis of PD-L1 N192, N200 and N219 glycosylation suggests that glycosylation antagonizes GSK3β binding. In this regard, only non-glycosylated PD-L1 forms a complex with GSK3β and β-TrCP. We also demonstrate that epidermal growth factor (EGF) stabilizes PD-L1 via GSK3β inactivation in basal-like breast cancer. Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse models. Together, our results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy.
Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation. |
|---|---|
| AbstractList | Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and
N
-glycosylation. We show that glycogen synthase kinase 3β (GSK3β) interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. In-depth analysis of PD-L1 N192, N200 and N219 glycosylation suggests that glycosylation antagonizes GSK3β binding. In this regard, only non-glycosylated PD-L1 forms a complex with GSK3β and β-TrCP. We also demonstrate that epidermal growth factor (EGF) stabilizes PD-L1 via GSK3β inactivation in basal-like breast cancer. Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse models. Together, our results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy.
Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation. Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N-glycosylation. We show that glycogen synthase kinase 3β (GSK3β) interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. In-depth analysis of PD-L1 N192, N200 and N219 glycosylation suggests that glycosylation antagonizes GSK3β binding. In this regard, only non-glycosylated PD-L1 forms a complex with GSK3β and β-TrCP. We also demonstrate that epidermal growth factor (EGF) stabilizes PD-L1 via GSK3β inactivation in basal-like breast cancer. Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse models. Together, our results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy. Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation. Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N-glycosylation. We show that glycogen synthase kinase 3β (GSK3β) interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. In-depth analysis of PD-L1 N192, N200 and N219 glycosylation suggests that glycosylation antagonizes GSK3β binding. In this regard, only non-glycosylated PD-L1 forms a complex with GSK3β and β-TrCP. We also demonstrate that epidermal growth factor (EGF) stabilizes PD-L1 via GSK3β inactivation in basal-like breast cancer. Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse models. Together, our results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy.Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N-glycosylation. We show that glycogen synthase kinase 3β (GSK3β) interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. In-depth analysis of PD-L1 N192, N200 and N219 glycosylation suggests that glycosylation antagonizes GSK3β binding. In this regard, only non-glycosylated PD-L1 forms a complex with GSK3β and β-TrCP. We also demonstrate that epidermal growth factor (EGF) stabilizes PD-L1 via GSK3β inactivation in basal-like breast cancer. Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse models. Together, our results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy. Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N -glycosylation. We show that glycogen synthase kinase 3β (GSK3β) interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. In-depth analysis of PD-L1 N192, N200 and N219 glycosylation suggests that glycosylation antagonizes GSK3β binding. In this regard, only non-glycosylated PD-L1 forms a complex with GSK3β and β-TrCP. We also demonstrate that epidermal growth factor (EGF) stabilizes PD-L1 via GSK3β inactivation in basal-like breast cancer. Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse models. Together, our results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy. |
| ArticleNumber | 12632 |
| Author | Lim, Seung-Oe Khoo, Kay-Hooi Wu, Yun Yamaguchi, Hirohito Yao, Jun Chang, Shih-Shin Ding, Qingqing Hung, Mien-Chie Allison, James P. Chan, Li-Chuan Lee, Cheng-Chung Hortobagyi, Gabriel N. Lee, Heng-Huan Wu, Hsing-Ju Wang, Yan Yu, Dihua Hsu, Jung-Mao Sahin, Aysegul A. Hsu, Jennifer L. Li, Chia-Wei Kuo, Chu-Wei Kim, Taewan Xia, Weiya Cha, Jong-Ho |
| Author_xml | – sequence: 1 givenname: Chia-Wei surname: Li fullname: Li, Chia-Wei organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 2 givenname: Seung-Oe surname: Lim fullname: Lim, Seung-Oe organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 3 givenname: Weiya surname: Xia fullname: Xia, Weiya organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 4 givenname: Heng-Huan surname: Lee fullname: Lee, Heng-Huan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 5 givenname: Li-Chuan surname: Chan fullname: Chan, Li-Chuan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston – sequence: 6 givenname: Chu-Wei surname: Kuo fullname: Kuo, Chu-Wei organization: Core Facilities for Protein Structural Analysis, Academia Sinica, Institute of Biological Chemistry, Academia Sinica – sequence: 7 givenname: Kay-Hooi surname: Khoo fullname: Khoo, Kay-Hooi organization: Institute of Biological Chemistry, Academia Sinica – sequence: 8 givenname: Shih-Shin surname: Chang fullname: Chang, Shih-Shin organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston – sequence: 9 givenname: Jong-Ho surname: Cha fullname: Cha, Jong-Ho organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University – sequence: 10 givenname: Taewan surname: Kim fullname: Kim, Taewan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 11 givenname: Jennifer L. surname: Hsu fullname: Hsu, Jennifer L. organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Department of Biotechnology, Asia University – sequence: 12 givenname: Yun surname: Wu fullname: Wu, Yun organization: Department of Pathology, The University of Texas MD Anderson Cancer Center – sequence: 13 givenname: Jung-Mao surname: Hsu fullname: Hsu, Jung-Mao organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 14 givenname: Hirohito surname: Yamaguchi fullname: Yamaguchi, Hirohito organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 15 givenname: Qingqing surname: Ding fullname: Ding, Qingqing organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 16 givenname: Yan surname: Wang fullname: Wang, Yan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 17 givenname: Jun surname: Yao fullname: Yao, Jun organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 18 givenname: Cheng-Chung surname: Lee fullname: Lee, Cheng-Chung organization: Core Facilities for Protein Structural Analysis, Academia Sinica – sequence: 19 givenname: Hsing-Ju surname: Wu fullname: Wu, Hsing-Ju organization: Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University – sequence: 20 givenname: Aysegul A. surname: Sahin fullname: Sahin, Aysegul A. organization: Department of Pathology, The University of Texas MD Anderson Cancer Center – sequence: 21 givenname: James P. surname: Allison fullname: Allison, James P. organization: Department of Immunology, The University of Texas MD Anderson Cancer Center – sequence: 22 givenname: Dihua surname: Yu fullname: Yu, Dihua organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston – sequence: 23 givenname: Gabriel N. orcidid: 0000-0002-4873-4412 surname: Hortobagyi fullname: Hortobagyi, Gabriel N. organization: Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center – sequence: 24 givenname: Mien-Chie surname: Hung fullname: Hung, Mien-Chie email: mhung@mdanderson.org organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Department of Biotechnology, Asia University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27572267$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkkFr3DAQhU1JadI0p96LoZdC6lZjSZZ0CZSQpoFALyk9ClmSHS22tJXswPbXV46TsgmZi8Tom8eb0bwtDnzwtijeA_oCCPOvXodxTFA3uH5VHNWIQAWsxgd798PiJKUNyoEFcELeFIc1o6yuG3ZU_L4cdjqk3aAmF3ypvCnTpFo3uL9rJnTlNoY-qnG0pjRWTbfl4PoMVlCmebuNNiWbyptK22EolZ7cnZt274rXnRqSPXk4j4tf3y9uzn9U1z8vr86_XVeaQj1VtCW04R2xgqPOaKOyRehQQ2vcEOAUdVgoRg3GDSccMDEU6xZaalrKeKvwcXG16pqgNnIb3ajiTgbl5H0ixF6qODk9WClouwSvqWGkE0oYRrUVDLhpke4WrbNVazu3uVlt_RTV8ET06Yt3t7IPd5IiwA0iWeDTg0AMf2abJjm6tIxFeRvmJIFD7hYEsIx-fIZuwhx9HtVCEYExEwv1Yd_RfyuP_5cBWAEdQ0rRdlK76f7jskE3SEByWRO5tya55vRZzaPsy_TnlU6Z8r2Ne0ZfwP8BOYjO1w |
| CitedBy_id | crossref_primary_10_3389_fimmu_2022_1088560 crossref_primary_10_3389_fonc_2022_1093496 crossref_primary_10_1038_s41388_021_01896_1 crossref_primary_10_1021_acs_jmedchem_1c00120 crossref_primary_10_3390_cells13141193 crossref_primary_10_1158_0008_5472_CAN_18_1892 crossref_primary_10_1186_s12935_021_01991_z crossref_primary_10_1002_mc_23170 crossref_primary_10_1186_s13578_022_00756_z crossref_primary_10_1093_jnci_djad154 crossref_primary_10_1038_s41467_019_11449_6 crossref_primary_10_1016_j_biomaterials_2018_11_019 crossref_primary_10_1039_D2RA02903K crossref_primary_10_1002_mco2_10 crossref_primary_10_1016_j_immuni_2018_03_014 crossref_primary_10_1186_s12967_024_05498_9 crossref_primary_10_1038_s41388_023_02622_9 crossref_primary_10_3389_fonc_2021_703681 crossref_primary_10_1002_2211_5463_12998 crossref_primary_10_1136_jitc_2023_007670 crossref_primary_10_1186_s13578_023_01137_w crossref_primary_10_1002_path_5280 crossref_primary_10_2174_0113892010303244240718075729 crossref_primary_10_1038_s41598_023_42739_1 crossref_primary_10_1007_s10555_016_9649_6 crossref_primary_10_1158_0008_5472_CAN_20_1264 crossref_primary_10_1016_j_apsb_2021_03_010 crossref_primary_10_1038_s41388_019_0700_2 crossref_primary_10_1136_jitc_2024_008917 crossref_primary_10_3390_cancers13020309 crossref_primary_10_1016_j_bios_2022_114179 crossref_primary_10_3390_cells14020069 crossref_primary_10_1016_j_intimp_2024_112875 crossref_primary_10_1021_acsami_3c07648 crossref_primary_10_1038_s41423_023_01019_8 crossref_primary_10_1016_j_intimp_2020_107280 crossref_primary_10_1038_s41419_021_04356_6 crossref_primary_10_1038_s41420_019_0216_0 crossref_primary_10_1038_s42003_022_03845_4 crossref_primary_10_1093_femsre_fuab002 crossref_primary_10_3389_fimmu_2022_927265 crossref_primary_10_1007_s00018_024_05144_z crossref_primary_10_4143_crt_2019_183 crossref_primary_10_1038_s41467_022_29401_6 crossref_primary_10_1073_pnas_2114851119 crossref_primary_10_1111_imm_13801 crossref_primary_10_3389_fimmu_2024_1434078 crossref_primary_10_1038_s41388_020_01592_6 crossref_primary_10_1073_pnas_2216796120 crossref_primary_10_3390_ijms25147726 crossref_primary_10_3389_fonc_2022_815437 crossref_primary_10_1038_s41467_021_27651_4 crossref_primary_10_1021_acs_analchem_1c03287 crossref_primary_10_3389_fimmu_2025_1544104 crossref_primary_10_1101_cshperspect_a036863 crossref_primary_10_1038_s41421_022_00507_x crossref_primary_10_1186_s12929_020_00670_x crossref_primary_10_1016_j_ymthe_2022_07_006 crossref_primary_10_1038_s41389_023_00475_1 crossref_primary_10_1021_acs_analchem_0c01572 crossref_primary_10_3390_cancers12082054 crossref_primary_10_1016_j_intimp_2023_111294 crossref_primary_10_1136_jitc_2023_008303 crossref_primary_10_1172_JCI160456 crossref_primary_10_2147_JHC_S400472 crossref_primary_10_3389_fimmu_2024_1342086 crossref_primary_10_3390_cancers12061475 crossref_primary_10_1158_2767_9764_CRC_22_0468 crossref_primary_10_1111_cas_15110 crossref_primary_10_1002_smtd_202200549 crossref_primary_10_1186_s12964_024_01935_w crossref_primary_10_3389_fonc_2022_941666 crossref_primary_10_3389_fimmu_2021_670646 crossref_primary_10_1002_smll_202308688 crossref_primary_10_1002_eji_202048543 crossref_primary_10_1016_j_ccell_2016_11_013 crossref_primary_10_1126_sciadv_adp4917 crossref_primary_10_1073_pnas_1922778117 crossref_primary_10_3390_ijms25063173 crossref_primary_10_1002_jcp_29022 crossref_primary_10_3390_biomedicines10081805 crossref_primary_10_1186_s12916_021_02213_z crossref_primary_10_1016_j_compbiolchem_2020_107362 crossref_primary_10_1039_D3MD00636K crossref_primary_10_1007_s12672_025_01903_x crossref_primary_10_3390_cancers13236008 crossref_primary_10_1016_j_canlet_2021_05_007 crossref_primary_10_1038_s44321_024_00051_z crossref_primary_10_3390_cells13131155 crossref_primary_10_18632_oncotarget_26542 crossref_primary_10_3390_molecules28176386 crossref_primary_10_3390_ijms22105383 crossref_primary_10_1002_1878_0261_12664 crossref_primary_10_1007_s10555_021_09980_4 crossref_primary_10_1016_j_semcancer_2019_06_021 crossref_primary_10_1177_15330338211019442 crossref_primary_10_1038_s41422_018_0124_5 crossref_primary_10_1186_s12964_020_00612_y crossref_primary_10_1016_j_hbpd_2021_06_010 crossref_primary_10_3390_cells10082136 crossref_primary_10_1038_s41551_019_0375_6 crossref_primary_10_1039_D4CC05982D crossref_primary_10_3390_jpm13030529 crossref_primary_10_1186_s13045_024_01532_x crossref_primary_10_3390_cancers13184509 crossref_primary_10_1016_j_cell_2019_02_016 crossref_primary_10_1016_j_chembiol_2021_06_005 crossref_primary_10_1002_hed_25930 crossref_primary_10_1073_pnas_2012149117 crossref_primary_10_3390_cells10051100 crossref_primary_10_1016_j_semcancer_2021_04_002 crossref_primary_10_1186_s12967_024_05126_6 crossref_primary_10_1016_j_celrep_2021_109181 crossref_primary_10_1111_sji_13205 crossref_primary_10_3390_ph15121451 crossref_primary_10_1016_j_ebiom_2019_01_054 crossref_primary_10_1530_ERC_17_0376 crossref_primary_10_1136_jitc_2023_007529 crossref_primary_10_3389_fimmu_2023_1123244 crossref_primary_10_2147_OTT_S257050 crossref_primary_10_1038_s41467_024_48597_3 crossref_primary_10_1158_0008_5472_CAN_19_3133 crossref_primary_10_1016_j_cyto_2023_156271 crossref_primary_10_3389_fonc_2020_594782 crossref_primary_10_3390_jcm8122168 crossref_primary_10_1126_sciadv_ade4186 crossref_primary_10_1038_s41467_022_34346_x crossref_primary_10_3390_cancers12113173 crossref_primary_10_3892_br_2021_1460 crossref_primary_10_3389_fmolb_2022_934584 crossref_primary_10_1158_2326_6066_CIR_24_0298 crossref_primary_10_3389_fimmu_2024_1370367 crossref_primary_10_1016_j_hbpd_2022_08_002 crossref_primary_10_1038_s41598_025_88331_7 crossref_primary_10_3390_ijms21228770 crossref_primary_10_1186_s13046_018_0929_6 crossref_primary_10_1007_s10549_025_07659_w crossref_primary_10_1038_s41418_024_01432_0 crossref_primary_10_1038_s41467_024_54132_1 crossref_primary_10_1021_acsami_4c22466 crossref_primary_10_3390_ijms221910800 crossref_primary_10_3389_fimmu_2022_752065 crossref_primary_10_18632_oncotarget_13161 crossref_primary_10_1186_s12964_021_00816_w crossref_primary_10_1016_j_xpro_2022_101198 crossref_primary_10_1158_1078_0432_CCR_20_0778 crossref_primary_10_1016_j_molcel_2021_03_037 crossref_primary_10_1007_s11010_024_05106_w crossref_primary_10_3389_fonc_2023_1140133 crossref_primary_10_1021_acsptsci_4c00049 crossref_primary_10_1136_jitc_2023_008505 crossref_primary_10_1136_jitc_2021_002844 crossref_primary_10_4155_fmc_2021_0192 crossref_primary_10_1007_s12094_023_03240_3 crossref_primary_10_1016_j_ymthe_2020_12_032 crossref_primary_10_1016_j_intimp_2021_107876 crossref_primary_10_3390_ijms21051806 crossref_primary_10_1177_1758835920944116 crossref_primary_10_1111_1440_1681_13056 crossref_primary_10_1016_j_nantod_2021_101083 crossref_primary_10_1016_j_celrep_2021_110174 crossref_primary_10_1016_j_ccell_2016_10_010 crossref_primary_10_1016_j_drudis_2024_104181 crossref_primary_10_1158_1541_7786_MCR_19_0517 crossref_primary_10_1158_0008_5472_CAN_20_0471 crossref_primary_10_1186_s40164_023_00394_2 crossref_primary_10_1038_nature25015 crossref_primary_10_1158_2326_6066_CIR_20_0264 crossref_primary_10_1002_jhbp_12011 crossref_primary_10_1136_jitc_2020_001222 crossref_primary_10_3724_abbs_2024107 crossref_primary_10_18632_oncotarget_26582 crossref_primary_10_3389_fonc_2021_621050 crossref_primary_10_1007_s10555_024_10174_x crossref_primary_10_1016_j_semcancer_2021_11_006 crossref_primary_10_3389_fimmu_2018_02485 crossref_primary_10_18632_aging_102646 crossref_primary_10_1016_j_pathol_2020_09_018 crossref_primary_10_1111_febs_16383 crossref_primary_10_1089_omi_2024_0174 crossref_primary_10_1186_s40164_025_00627_6 crossref_primary_10_1016_j_bbrc_2017_07_007 crossref_primary_10_1158_2767_9764_CRC_23_0493 crossref_primary_10_1186_s12951_025_03171_x crossref_primary_10_1126_sciadv_adg2809 crossref_primary_10_1021_acs_jmedchem_2c01702 crossref_primary_10_1186_s12964_023_01384_x crossref_primary_10_1186_s13045_018_0589_1 crossref_primary_10_3390_cancers16152676 crossref_primary_10_1038_s41420_025_02368_1 crossref_primary_10_1158_0008_5472_CAN_18_0040 crossref_primary_10_1177_1758835920930333 crossref_primary_10_14789_jmj_JMJ22_0039_OA crossref_primary_10_3389_fimmu_2023_1230135 crossref_primary_10_3390_cancers11101617 crossref_primary_10_1002_ptr_7297 crossref_primary_10_3389_fimmu_2023_1189953 crossref_primary_10_3389_fphar_2018_00536 crossref_primary_10_1002_ctm2_725 crossref_primary_10_1038_s41598_017_08424_w crossref_primary_10_1158_2326_6066_CIR_18_0086 crossref_primary_10_3390_cells14020103 crossref_primary_10_3724_abbs_2024085 crossref_primary_10_1021_acs_biochem_9b00113 crossref_primary_10_1186_s12964_019_0490_8 crossref_primary_10_3389_fimmu_2021_806043 crossref_primary_10_3389_fphar_2017_00332 crossref_primary_10_1002_advs_202207458 crossref_primary_10_3389_fimmu_2023_1255667 crossref_primary_10_1038_s41423_023_00980_8 crossref_primary_10_2147_OTT_S262909 crossref_primary_10_1038_s41467_021_24769_3 crossref_primary_10_1186_s40164_024_00515_5 crossref_primary_10_1016_j_ccell_2019_06_008 crossref_primary_10_1016_j_fct_2019_05_045 crossref_primary_10_1111_febs_16084 crossref_primary_10_1038_s43018_023_00695_9 crossref_primary_10_1016_j_urolonc_2020_11_029 crossref_primary_10_1016_j_ccell_2019_06_006 crossref_primary_10_1007_s12072_023_10572_3 crossref_primary_10_1007_s13258_022_01291_4 crossref_primary_10_1016_j_ijbiomac_2023_127911 crossref_primary_10_1186_s12943_019_1062_7 crossref_primary_10_1007_s00439_024_02673_2 crossref_primary_10_1007_s00262_022_03305_2 crossref_primary_10_1021_acs_analchem_4c00330 crossref_primary_10_1038_s41467_021_21099_2 crossref_primary_10_1111_bjd_19485 crossref_primary_10_1172_jci_insight_153323 crossref_primary_10_1038_s41598_022_25417_6 crossref_primary_10_1016_j_apsb_2020_11_005 crossref_primary_10_1002_anbr_202200017 crossref_primary_10_1016_j_cmet_2022_08_002 crossref_primary_10_1016_j_ymthe_2021_04_029 crossref_primary_10_1002_ange_202103696 crossref_primary_10_1016_j_gendis_2022_01_002 crossref_primary_10_1038_s41392_020_00418_x crossref_primary_10_1158_2326_6066_CIR_22_0815 crossref_primary_10_1177_17588359241242406 crossref_primary_10_1186_s12885_024_12811_8 crossref_primary_10_1111_1759_7714_14564 crossref_primary_10_3389_fimmu_2017_01597 crossref_primary_10_1016_j_xcrm_2023_101253 crossref_primary_10_3389_fimmu_2023_1229397 crossref_primary_10_2967_jnumed_119_241364 crossref_primary_10_1038_s41467_022_29530_y crossref_primary_10_1093_jmcb_mjad070 crossref_primary_10_1186_s12943_024_02176_8 crossref_primary_10_1038_s41467_021_22467_8 crossref_primary_10_1007_s13258_022_01238_9 crossref_primary_10_3390_nu13051718 crossref_primary_10_1016_j_oraloncology_2023_106562 crossref_primary_10_3389_fimmu_2019_01337 crossref_primary_10_3390_biomedicines10051181 crossref_primary_10_1038_aps_2017_123 crossref_primary_10_1111_febs_16185 crossref_primary_10_1016_j_phymed_2021_153867 crossref_primary_10_1016_j_semcancer_2019_08_015 crossref_primary_10_1016_j_ymthe_2023_07_021 crossref_primary_10_1002_ange_201916039 crossref_primary_10_1053_j_gastro_2019_01_252 crossref_primary_10_3390_cancers13174426 crossref_primary_10_1016_j_phymed_2020_153394 crossref_primary_10_3389_fimmu_2020_568931 crossref_primary_10_1186_s40425_019_0770_2 crossref_primary_10_1016_j_mam_2022_101097 crossref_primary_10_3390_ijms18122632 crossref_primary_10_1002_smll_202207201 crossref_primary_10_1186_s12916_021_02161_8 crossref_primary_10_3389_fimmu_2024_1383456 crossref_primary_10_1016_j_ejphar_2022_174822 crossref_primary_10_3389_fimmu_2022_920021 crossref_primary_10_1007_s12094_024_03835_4 crossref_primary_10_1016_j_tranon_2020_100847 crossref_primary_10_1016_j_apsb_2021_09_010 crossref_primary_10_1186_s12967_023_04135_1 crossref_primary_10_1111_jth_15478 crossref_primary_10_3389_fimmu_2018_02754 crossref_primary_10_3390_ijms20112823 crossref_primary_10_1186_s13045_020_01027_5 crossref_primary_10_31083_j_fbl2701023 crossref_primary_10_1038_s41420_024_02182_1 crossref_primary_10_1002_ctm2_803 crossref_primary_10_1096_fj_202400061RR crossref_primary_10_3389_fonc_2022_1022542 crossref_primary_10_1016_j_humgen_2024_201332 crossref_primary_10_1016_j_phrs_2022_106242 crossref_primary_10_1186_s12964_023_01084_6 crossref_primary_10_3390_ijms22116097 crossref_primary_10_1038_s41467_023_44466_7 crossref_primary_10_1038_s41598_023_31543_6 crossref_primary_10_1007_s12094_024_03802_z crossref_primary_10_1002_advs_202310037 crossref_primary_10_1021_acs_jmedchem_0c00489 crossref_primary_10_3892_ijo_2022_5374 crossref_primary_10_1016_j_semcancer_2017_11_009 crossref_primary_10_3390_ijms21113949 crossref_primary_10_1155_2023_6082635 crossref_primary_10_1002_1878_0261_12804 crossref_primary_10_1038_s41375_018_0376_6 crossref_primary_10_1158_1541_7786_MCR_18_0831 crossref_primary_10_3389_fimmu_2025_1560135 crossref_primary_10_1038_s41467_021_25662_9 crossref_primary_10_3389_fonc_2021_771335 crossref_primary_10_1016_j_apsb_2020_06_014 crossref_primary_10_1007_s00262_019_02437_2 crossref_primary_10_1097_BS9_0000000000000149 crossref_primary_10_1158_0008_5472_CAN_23_2664 crossref_primary_10_1172_JCI162951 crossref_primary_10_1016_j_molmed_2021_06_005 crossref_primary_10_1186_s13046_022_02273_w crossref_primary_10_32604_or_2024_052664 crossref_primary_10_1016_j_tranon_2020_100862 crossref_primary_10_1172_JCI181314 crossref_primary_10_3389_fimmu_2020_00147 crossref_primary_10_4251_wjgo_v15_i7_1119 crossref_primary_10_1186_s10020_025_01088_7 crossref_primary_10_3390_ijms222413333 crossref_primary_10_1021_acs_analchem_3c03869 crossref_primary_10_3390_cells13050395 crossref_primary_10_3390_cancers15041093 crossref_primary_10_1021_acsomega_3c01547 crossref_primary_10_1186_s12885_022_09884_8 crossref_primary_10_3389_fonc_2019_00857 crossref_primary_10_1007_s11684_018_0657_5 crossref_primary_10_1093_glycob_cwad005 crossref_primary_10_3390_cancers11050604 crossref_primary_10_1080_21655979_2021_1996509 crossref_primary_10_3390_cancers13174438 crossref_primary_10_1158_2326_6066_CIR_22_0953 crossref_primary_10_1158_1541_7786_MCR_17_0166 crossref_primary_10_3390_ijms23073871 crossref_primary_10_1038_s41401_021_00631_6 crossref_primary_10_1038_s41467_017_01883_9 crossref_primary_10_1111_bph_16054 crossref_primary_10_3389_fimmu_2022_1021452 crossref_primary_10_1016_j_jtho_2021_04_003 crossref_primary_10_1097_JCMA_0000000000000252 crossref_primary_10_3389_fimmu_2024_1409238 crossref_primary_10_1097_PPO_0000000000000557 crossref_primary_10_1038_s41598_017_06002_8 crossref_primary_10_1051_medsci_2020099 crossref_primary_10_1007_s00262_018_2226_9 crossref_primary_10_1021_jacs_0c10008 crossref_primary_10_1186_s12885_022_10343_7 crossref_primary_10_3390_cancers11060771 crossref_primary_10_1038_s41419_023_06083_6 crossref_primary_10_1186_s12943_024_02023_w crossref_primary_10_3390_cancers12040924 crossref_primary_10_3390_ijms21238984 crossref_primary_10_3390_ijms232315384 crossref_primary_10_3389_fonc_2022_998388 crossref_primary_10_1021_acs_jmedchem_3c00551 crossref_primary_10_1038_s41467_023_37617_3 crossref_primary_10_1084_jem_20180870 crossref_primary_10_1126_scitranslmed_abg3072 crossref_primary_10_3390_ijms21197139 crossref_primary_10_1016_j_bcp_2020_113821 crossref_primary_10_1111_imm_13494 crossref_primary_10_1002_mc_22881 crossref_primary_10_3389_fmolb_2022_780200 crossref_primary_10_1038_nature23643 crossref_primary_10_6023_A24080248 crossref_primary_10_1007_s11904_019_00433_w crossref_primary_10_1016_j_canlet_2018_09_003 crossref_primary_10_1002_pep2_24392 crossref_primary_10_1016_j_bbrc_2021_05_022 crossref_primary_10_1021_acsnano_4c11334 crossref_primary_10_3389_fonc_2022_730530 crossref_primary_10_1016_j_bbcan_2023_189027 crossref_primary_10_1016_j_cellsig_2023_110994 crossref_primary_10_1016_j_cclet_2021_12_069 crossref_primary_10_1038_s42003_023_04581_z crossref_primary_10_3390_cells12020322 crossref_primary_10_3390_ijms25052939 crossref_primary_10_1002_stem_3190 crossref_primary_10_3390_ijms24087394 crossref_primary_10_1186_s13046_021_02055_w crossref_primary_10_1002_1873_3468_14191 crossref_primary_10_1002_adfm_201800025 crossref_primary_10_1016_j_bcp_2023_115984 crossref_primary_10_1136_jitc_2024_009444 crossref_primary_10_1186_s12885_019_5364_3 crossref_primary_10_1038_s43018_022_00444_4 crossref_primary_10_3390_cells12192338 crossref_primary_10_3389_fendo_2023_1216193 crossref_primary_10_1128_mcb_00171_22 crossref_primary_10_1016_j_freeradbiomed_2018_11_030 crossref_primary_10_1136_jitc_2021_004026 crossref_primary_10_1186_s13046_022_02335_z crossref_primary_10_1038_s41598_024_63181_x crossref_primary_10_1111_cas_14932 crossref_primary_10_1007_s40242_024_4004_x crossref_primary_10_1016_j_cca_2019_12_015 crossref_primary_10_1038_nature23669 crossref_primary_10_1002_advs_202304068 crossref_primary_10_1111_cts_13788 crossref_primary_10_1631_jzus_B2200195 crossref_primary_10_1007_s11426_022_1240_5 crossref_primary_10_1016_j_biotechadv_2023_108149 crossref_primary_10_1158_1535_7163_MCT_20_0497 crossref_primary_10_1038_s41392_024_01800_9 crossref_primary_10_1007_s12032_019_1270_4 crossref_primary_10_3389_fonc_2022_1101503 crossref_primary_10_1038_s41598_024_51804_2 crossref_primary_10_1016_j_imlet_2018_01_007 crossref_primary_10_1007_s11427_017_9176_7 crossref_primary_10_1016_j_gendis_2021_08_009 crossref_primary_10_1016_j_intimp_2023_110894 crossref_primary_10_1016_j_celrep_2017_07_027 crossref_primary_10_3390_cancers15010104 crossref_primary_10_3390_cells14040314 crossref_primary_10_1002_btpr_3439 crossref_primary_10_1016_j_semcancer_2022_08_009 crossref_primary_10_1186_s12864_023_09888_z crossref_primary_10_1080_2162402X_2018_1512943 crossref_primary_10_1016_j_chembiol_2023_05_010 crossref_primary_10_1158_0008_5472_CAN_21_2300 crossref_primary_10_1186_s12967_023_04257_6 crossref_primary_10_1002_1878_0261_13083 crossref_primary_10_1136_jitc_2022_005668 crossref_primary_10_1007_s11010_024_05033_w crossref_primary_10_1128_mBio_02824_21 crossref_primary_10_1016_j_compbiolchem_2023_107852 crossref_primary_10_1097_CCO_0000000000000680 crossref_primary_10_1002_jev2_12480 crossref_primary_10_1186_s40164_024_00518_2 crossref_primary_10_1016_j_tcb_2018_08_005 crossref_primary_10_1186_s12920_023_01431_z crossref_primary_10_1007_s10735_019_09829_9 crossref_primary_10_1080_26895293_2022_2049901 crossref_primary_10_1002_cac2_12465 crossref_primary_10_1186_s12964_022_00981_6 crossref_primary_10_1002_advs_202300759 crossref_primary_10_1084_jem_20221721 crossref_primary_10_1002_cac2_12460 crossref_primary_10_2147_IJGM_S381530 crossref_primary_10_3390_cancers14225633 crossref_primary_10_3390_ijms24098193 crossref_primary_10_1039_D1SC03059K crossref_primary_10_1136_jitc_2021_004129 crossref_primary_10_1186_s12967_024_05502_2 crossref_primary_10_1186_s13046_022_02469_0 crossref_primary_10_1080_17568919_2024_2366146 crossref_primary_10_1021_acssensors_4c00192 crossref_primary_10_3390_ijms20236074 crossref_primary_10_3390_cancers15123131 crossref_primary_10_1016_j_omtn_2021_05_011 crossref_primary_10_3390_proteomes10040035 crossref_primary_10_1093_glycob_cwaa117 crossref_primary_10_1016_j_vetimm_2021_110367 crossref_primary_10_1039_D2AN02004A crossref_primary_10_1111_imm_13573 crossref_primary_10_1080_15384047_2025_2455722 crossref_primary_10_1002_hep4_1682 crossref_primary_10_1038_s41422_022_00766_z crossref_primary_10_1172_JCI176136 crossref_primary_10_1016_j_csbj_2021_12_020 crossref_primary_10_1007_s00018_022_04431_x crossref_primary_10_1021_acs_jmedchem_0c02265 crossref_primary_10_1007_s00018_017_2660_4 crossref_primary_10_1021_acsabm_1c00507 crossref_primary_10_1136_jitc_2022_004871 crossref_primary_10_3390_ijms241310870 crossref_primary_10_1038_s41418_022_01102_z crossref_primary_10_1042_BSR20211370 crossref_primary_10_1007_s13402_023_00770_4 crossref_primary_10_1038_s12276_019_0295_2 crossref_primary_10_1002_advs_202410285 crossref_primary_10_1016_j_pan_2019_01_011 crossref_primary_10_1111_cas_13981 crossref_primary_10_3390_cancers17030498 crossref_primary_10_1158_1078_0432_CCR_18_0267 crossref_primary_10_1002_cam4_7083 crossref_primary_10_1186_s13046_023_02758_2 crossref_primary_10_1039_D4TB00769G crossref_primary_10_1126_sciimmunol_adp7302 crossref_primary_10_26508_lsa_202302368 crossref_primary_10_3390_cells10123309 crossref_primary_10_3389_fimmu_2021_752466 crossref_primary_10_1186_s12885_024_12712_w crossref_primary_10_4049_jimmunol_1901013 crossref_primary_10_1016_j_exppara_2018_11_003 crossref_primary_10_1038_s41423_019_0348_4 crossref_primary_10_1002_cam4_1675 crossref_primary_10_1038_s41419_023_05878_x crossref_primary_10_1016_j_bcp_2022_115113 crossref_primary_10_3389_fcell_2021_769229 crossref_primary_10_1002_hep_31921 crossref_primary_10_1016_j_semcancer_2022_02_010 crossref_primary_10_1016_j_molcel_2018_07_030 crossref_primary_10_1111_cas_15818 crossref_primary_10_1155_2021_6668573 crossref_primary_10_1084_jem_20191115 crossref_primary_10_3389_fimmu_2023_1120434 crossref_primary_10_1158_1535_7163_MCT_23_0449 crossref_primary_10_1167_iovs_65_3_37 crossref_primary_10_1093_carcin_bgab063 crossref_primary_10_1016_j_intimp_2024_113186 crossref_primary_10_29219_fnr_v68_10974 crossref_primary_10_1080_2162402X_2021_1947569 crossref_primary_10_1097_JBR_0000000000000025 crossref_primary_10_2174_1389203719666180928105632 crossref_primary_10_3389_fonc_2020_01221 crossref_primary_10_1016_j_bbrc_2021_05_034 crossref_primary_10_1016_j_molcel_2019_09_030 crossref_primary_10_3389_fphar_2022_972046 crossref_primary_10_1155_2022_3659714 crossref_primary_10_2147_JHC_S417407 crossref_primary_10_1002_jcp_29671 crossref_primary_10_1136_jitc_2022_006345 crossref_primary_10_1158_1078_0432_CCR_16_3215 crossref_primary_10_1038_s12276_024_01340_w crossref_primary_10_1080_07853890_2021_1937694 crossref_primary_10_3390_ijms26031238 crossref_primary_10_1016_j_apmt_2022_101677 crossref_primary_10_1111_1751_2980_12538 crossref_primary_10_3390_biom11081107 crossref_primary_10_1292_jvms_23_0003 crossref_primary_10_1016_j_tranon_2025_102275 crossref_primary_10_1038_s41388_018_0347_4 crossref_primary_10_2185_jrm_2022_040 crossref_primary_10_1002_hed_26827 crossref_primary_10_1038_s41420_024_02027_x crossref_primary_10_1038_nri_2018_3 crossref_primary_10_1002_mco2_70062 crossref_primary_10_3892_or_2023_8481 crossref_primary_10_1007_s00018_020_03637_1 crossref_primary_10_1007_s11626_023_00755_5 crossref_primary_10_1016_j_tranon_2021_101047 crossref_primary_10_1038_s41467_021_23864_9 crossref_primary_10_1016_j_ccell_2018_01_015 crossref_primary_10_1038_s12276_021_00670_3 crossref_primary_10_1038_s41556_020_0575_z crossref_primary_10_1186_s12929_021_00746_2 crossref_primary_10_1038_s41368_024_00311_1 crossref_primary_10_3389_fimmu_2022_839901 crossref_primary_10_1111_cas_14197 crossref_primary_10_1155_2020_5497015 crossref_primary_10_1016_j_athoracsur_2018_08_056 crossref_primary_10_1038_s41422_020_0315_8 crossref_primary_10_1016_j_lungcan_2024_107788 crossref_primary_10_3390_ijms19092733 crossref_primary_10_1016_j_bioorg_2021_105432 crossref_primary_10_1016_j_ccell_2018_01_009 crossref_primary_10_1080_2162402X_2017_1327494 crossref_primary_10_3390_biomedicines12071446 crossref_primary_10_3390_cancers12113129 crossref_primary_10_1093_carcin_bgz177 crossref_primary_10_1007_s00262_023_03530_3 crossref_primary_10_3389_fimmu_2024_1392546 crossref_primary_10_3390_ijms25179276 crossref_primary_10_1038_s41568_020_00322_0 crossref_primary_10_1038_s41418_023_01219_9 crossref_primary_10_3390_cancers14030751 crossref_primary_10_1016_j_trsl_2022_12_008 crossref_primary_10_1038_s41590_023_01471_8 crossref_primary_10_3390_cells11010162 crossref_primary_10_3748_wjg_v28_i29_3869 crossref_primary_10_1007_s00018_022_04365_4 crossref_primary_10_1002_anie_201916039 crossref_primary_10_1136_jitc_2022_006483 crossref_primary_10_1177_17588359241258443 crossref_primary_10_1016_j_ijbiomac_2023_128574 crossref_primary_10_1016_j_intimp_2019_106003 crossref_primary_10_1186_s12935_024_03293_6 crossref_primary_10_1186_s13027_024_00584_5 crossref_primary_10_3390_genes16030307 crossref_primary_10_1016_j_canlet_2019_11_020 crossref_primary_10_1038_s41467_020_15364_z crossref_primary_10_1016_j_tranon_2020_101003 crossref_primary_10_1039_C8NR01478G crossref_primary_10_1186_s12943_018_0928_4 crossref_primary_10_1186_s13046_019_1044_z crossref_primary_10_3389_fimmu_2022_1084339 crossref_primary_10_3389_fimmu_2024_1405485 crossref_primary_10_3390_ijms22020791 crossref_primary_10_1126_scisignal_aam5681 crossref_primary_10_3389_fimmu_2025_1510179 crossref_primary_10_3390_biomedicines9111702 crossref_primary_10_5483_BMBRep_2021_54_1_241 crossref_primary_10_1080_2162402X_2020_1831153 crossref_primary_10_1074_mcp_RA117_000037 crossref_primary_10_1080_08820139_2023_2177168 crossref_primary_10_1016_j_vetimm_2018_02_007 crossref_primary_10_1186_s40164_022_00297_8 crossref_primary_10_1186_s12943_024_01977_1 crossref_primary_10_3389_fimmu_2019_02293 crossref_primary_10_1111_aos_13833 crossref_primary_10_1038_s41467_018_04313_6 crossref_primary_10_1038_s41467_021_22618_x crossref_primary_10_1158_0008_5472_CAN_19_2314 crossref_primary_10_1158_1541_7786_MCR_21_0147 crossref_primary_10_1158_0008_5472_CAN_19_1108 crossref_primary_10_3390_ijms24032506 crossref_primary_10_1093_toxsci_kfae003 crossref_primary_10_1093_noajnl_vdz058 crossref_primary_10_1007_s00216_023_04919_w crossref_primary_10_1186_s13046_021_01987_7 crossref_primary_10_1016_j_semcancer_2019_11_011 crossref_primary_10_1002_1878_0261_13567 crossref_primary_10_1016_j_canlet_2021_08_008 crossref_primary_10_3390_ijms22031340 crossref_primary_10_1038_s41467_024_51242_8 crossref_primary_10_1080_21645515_2020_1730658 crossref_primary_10_1016_j_actbio_2023_03_002 crossref_primary_10_1016_j_jconrel_2022_01_004 crossref_primary_10_1080_2162402X_2020_1738798 crossref_primary_10_3390_cimb46030136 crossref_primary_10_1038_s41586_018_0756_0 crossref_primary_10_3390_medicines10020015 crossref_primary_10_1002_anie_202103696 crossref_primary_10_1084_jem_20211505 crossref_primary_10_3389_fonc_2021_649338 crossref_primary_10_1080_15384047_2022_2088984 crossref_primary_10_1038_s41418_022_01012_0 crossref_primary_10_1038_s41388_019_0877_4 crossref_primary_10_3390_life15010126 crossref_primary_10_1093_abt_tbad004 crossref_primary_10_1002_1878_0261_13699 crossref_primary_10_1007_s10120_024_01500_x crossref_primary_10_1021_acs_jproteome_0c00521 crossref_primary_10_1136_jitc_2024_010148 crossref_primary_10_1038_s41417_023_00693_0 crossref_primary_10_21053_ceo_2018_00150 crossref_primary_10_3389_or_2022_10568 crossref_primary_10_3389_fimmu_2023_1145682 crossref_primary_10_1186_s40364_022_00396_y crossref_primary_10_1042_BST20200763 crossref_primary_10_1073_pnas_2303400120 crossref_primary_10_1080_15384101_2018_1489177 crossref_primary_10_1093_biolre_ioad105 crossref_primary_10_1016_j_molmed_2023_05_006 crossref_primary_10_3389_fimmu_2024_1436174 crossref_primary_10_3390_ijms23158599 crossref_primary_10_1038_s41389_024_00532_3 crossref_primary_10_3390_cancers16061237 crossref_primary_10_1002_advs_202303175 crossref_primary_10_1159_000503339 crossref_primary_10_3389_fimmu_2022_989928 crossref_primary_10_1007_s00262_021_03097_x crossref_primary_10_1080_2162402X_2019_1655361 crossref_primary_10_3390_membranes12080775 crossref_primary_10_1002_1873_3468_14032 crossref_primary_10_1111_febs_15585 crossref_primary_10_3389_fonc_2020_569202 crossref_primary_10_1016_j_semcancer_2020_06_016 crossref_primary_10_1038_s41589_018_0161_x crossref_primary_10_1158_1541_7786_MCR_20_0967 crossref_primary_10_3389_fphar_2022_828440 crossref_primary_10_1016_j_phymed_2024_155825 crossref_primary_10_3390_cancers14246188 crossref_primary_10_1016_j_lfs_2023_121781 crossref_primary_10_1038_s41388_018_0303_3 crossref_primary_10_3389_fphar_2021_678409 crossref_primary_10_3390_cancers14051343 crossref_primary_10_1002_ctm2_70161 crossref_primary_10_1016_j_jmb_2024_168500 crossref_primary_10_1126_sciadv_abd2712 crossref_primary_10_1016_j_biopha_2023_115519 crossref_primary_10_1002_cncr_34729 crossref_primary_10_1158_2326_6066_CIR_19_0159 crossref_primary_10_3390_pharmaceutics14091768 crossref_primary_10_3389_fimmu_2023_1250559 crossref_primary_10_1038_s41392_021_00825_8 crossref_primary_10_3389_fimmu_2023_1029438 crossref_primary_10_1038_s41419_020_03140_2 crossref_primary_10_1186_s12943_020_01304_4 crossref_primary_10_3389_fonc_2022_958043 crossref_primary_10_1136_jitc_2022_005461 crossref_primary_10_1155_2024_5512422 crossref_primary_10_1016_j_jelechem_2025_118999 |
| Cites_doi | 10.1158/0008-5472.CAN-15-1941 10.1016/j.devcel.2009.06.016 10.1056/NEJMoa1003466 10.1016/j.immuni.2007.05.016 10.4049/jimmunol.1100056 10.1074/jbc.M600788200 10.3389/fonc.2012.00015 10.1200/JCO.2009.26.7609 10.1016/j.str.2013.03.003 10.1128/MCB.00620-06 10.1038/35096075 10.1038/ncb1173 10.1038/nature14404 10.1146/annurev.biochem.73.011303.073752 10.1016/j.ymeth.2006.10.002 10.1038/328267a0 10.1038/nm730 10.1042/bj3590001 10.1158/2159-8290.CD-13-0310 10.1053/j.gastro.2008.07.027 10.1038/363418a0 10.1016/j.cell.2014.01.043 10.1038/nature12080 10.1002/j.1460-2075.1992.tb05481.x 10.1016/j.cell.2007.05.058 10.1038/nrc3239 10.1242/jcs.00384 10.1016/j.febslet.2004.07.083 10.1016/j.chembiol.2013.09.010 10.1016/S0969-2126(02)00937-1 10.1101/cshperspect.a005199 10.1038/ncb1676 10.1158/1078-0432.CCR-12-2063 10.1084/jem.192.7.1027 10.1038/labinvest.2013.130 10.1038/ncb2173 10.1016/S1534-5807(03)00153-9 10.1016/S1534-5807(03)00154-0 10.1016/j.sbi.2011.08.005 10.1016/S0092-8674(04)00302-2 10.1126/science.291.5512.2364 10.1038/nm1517 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2016 Copyright Nature Publishing Group Aug 2016 Copyright © 2016, The Author(s) 2016 The Author(s) |
| Copyright_xml | – notice: The Author(s) 2016 – notice: Copyright Nature Publishing Group Aug 2016 – notice: Copyright © 2016, The Author(s) 2016 The Author(s) |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/ncomms12632 |
| DatabaseName | SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journal Collection url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 11 |
| ExternalDocumentID | oai_doaj_org_article_95bbbbb825d74f9a9d75ce9718db0cfa PMC5013604 4164277551 27572267 10_1038_ncomms12632 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA109311 – fundername: NCI NIH HHS grantid: P30 CA016672 – fundername: NIEHS NIH HHS grantid: 27303C0140 – fundername: NCI NIH HHS grantid: P01 CA099031 |
| GroupedDBID | --- 0R~ 39C 3V. 4.4 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BAPOH BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EJD EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AARCD AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI RC3 SOI 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c512t-5b4568f4e980fdcda3911f06523641850f39a75d336848134d53cb1b5db578ba3 |
| IEDL.DBID | M48 |
| ISSN | 2041-1723 |
| IngestDate | Wed Aug 27 01:14:52 EDT 2025 Thu Aug 21 18:21:15 EDT 2025 Thu Jul 10 18:05:27 EDT 2025 Wed Aug 13 09:41:59 EDT 2025 Thu Apr 03 07:02:29 EDT 2025 Thu Apr 24 22:51:05 EDT 2025 Tue Jul 01 02:31:25 EDT 2025 Fri Feb 21 02:40:34 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c512t-5b4568f4e980fdcda3911f06523641850f39a75d336848134d53cb1b5db578ba3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work |
| ORCID | 0000-0002-4873-4412 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/ncomms12632 |
| PMID | 27572267 |
| PQID | 1814933797 |
| PQPubID | 546298 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_95bbbbb825d74f9a9d75ce9718db0cfa pubmedcentral_primary_oai_pubmedcentral_nih_gov_5013604 proquest_miscellaneous_1815681917 proquest_journals_1814933797 pubmed_primary_27572267 crossref_citationtrail_10_1038_ncomms12632 crossref_primary_10_1038_ncomms12632 springer_journals_10_1038_ncomms12632 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20160830 |
| PublicationDateYYYYMMDD | 2016-08-30 |
| PublicationDate_xml | – month: 8 year: 2016 text: 20160830 day: 30 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2016 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Hodi (CR3) 2010; 363 Guardavaccaro (CR25) 2003; 4 Doble, Woodgett (CR17) 2003; 116 Yamaguchi, Hsu, Hung (CR32) 2012; 2 Parsa (CR33) 2007; 13 Cheung, Reithmeier (CR8) 2007; 41 von Itzstein (CR13) 1993; 363 Frame, Cohen (CR18) 2001; 359 Margottin-Goguet (CR24) 2003; 4 Lim (CR40) 2008; 135 Brunet (CR14) 1987; 328 Hu (CR36) 2004; 117 MacDonald, Tamai, He (CR21) 2009; 17 Lee (CR39) 2007; 130 Zhou (CR26) 2006; 281 Spranger, Bao, Gajewski (CR1) 2015; 523 Sznol, Chen (CR6) 2013; 19 Yang (CR29) 2011; 187 Pardoll (CR7) 2012; 12 Li (CR42) 2016; 76 Chang (CR38) 2011; 13 Freeman (CR2) 2000; 192 Helenius, Aebi (CR11) 2001; 291 Zhou (CR20) 2004; 6 Cohen, Frame (CR35) 2001; 2 Helenius, Aebi (CR12) 2004; 73 Ishida, Agata, Shibahara, Honjo (CR30) 1992; 11 Yang (CR31) 2008; 10 Hudak, Bertozzi (CR15) 2014; 21 Butte, Keir, Phamduy, Sharpe, Freeman (CR28) 2007; 27 Shen (CR37) 2013; 497 Akbay (CR34) 2013; 3 Dong (CR4) 2002; 8 Stanley (CR22) 2011; 3 Sheppard (CR41) 2004; 574 Schwarz, Aebi (CR9) 2011; 21 Velcheti (CR5) 2014; 94 Croci (CR16) 2014; 156 Vigdorovich (CR23) 2013; 21 Ding (CR19) 2007; 27 Huang (CR27) 2003; 11 Brahmer (CR10) 2010; 28 Y Ishida (BFncomms12632_CR30) 1992; 11 GJ Freeman (BFncomms12632_CR2) 2000; 192 M von Itzstein (BFncomms12632_CR13) 1993; 363 A Helenius (BFncomms12632_CR12) 2004; 73 J Yang (BFncomms12632_CR29) 2011; 187 CW Li (BFncomms12632_CR42) 2016; 76 JR Brahmer (BFncomms12632_CR10) 2010; 28 MC Hu (BFncomms12632_CR36) 2004; 117 V Vigdorovich (BFncomms12632_CR23) 2013; 21 D Guardavaccaro (BFncomms12632_CR25) 2003; 4 AT Parsa (BFncomms12632_CR33) 2007; 13 JE Hudak (BFncomms12632_CR15) 2014; 21 EA Akbay (BFncomms12632_CR34) 2013; 3 A Helenius (BFncomms12632_CR11) 2001; 291 BP Zhou (BFncomms12632_CR20) 2004; 6 SO Lim (BFncomms12632_CR40) 2008; 135 JF Brunet (BFncomms12632_CR14) 1987; 328 JC Cheung (BFncomms12632_CR8) 2007; 41 JY Yang (BFncomms12632_CR31) 2008; 10 Q Ding (BFncomms12632_CR19) 2007; 27 S Frame (BFncomms12632_CR18) 2001; 359 DO Croci (BFncomms12632_CR16) 2014; 156 M Sznol (BFncomms12632_CR6) 2013; 19 FS Hodi (BFncomms12632_CR3) 2010; 363 H Yamaguchi (BFncomms12632_CR32) 2012; 2 P Cohen (BFncomms12632_CR35) 2001; 2 BT MacDonald (BFncomms12632_CR21) 2009; 17 V Velcheti (BFncomms12632_CR5) 2014; 94 GL Zhou (BFncomms12632_CR26) 2006; 281 DF Lee (BFncomms12632_CR39) 2007; 130 F Schwarz (BFncomms12632_CR9) 2011; 21 F Margottin-Goguet (BFncomms12632_CR24) 2003; 4 KA Sheppard (BFncomms12632_CR41) 2004; 574 J Shen (BFncomms12632_CR37) 2013; 497 H Dong (BFncomms12632_CR4) 2002; 8 BW Doble (BFncomms12632_CR17) 2003; 116 X Huang (BFncomms12632_CR27) 2003; 11 CJ Chang (BFncomms12632_CR38) 2011; 13 S Spranger (BFncomms12632_CR1) 2015; 523 MJ Butte (BFncomms12632_CR28) 2007; 27 DM Pardoll (BFncomms12632_CR7) 2012; 12 P Stanley (BFncomms12632_CR22) 2011; 3 |
| References_xml | – volume: 76 start-page: 1451 year: 2016 end-page: 1462 ident: CR42 article-title: AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-1941 – volume: 17 start-page: 9 year: 2009 end-page: 26 ident: CR21 article-title: Wnt/beta-catenin signaling: components, mechanisms, and diseases publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.06.016 – volume: 363 start-page: 711 year: 2010 end-page: 723 ident: CR3 article-title: Improved survival with ipilimumab in patients with metastatic melanoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1003466 – volume: 27 start-page: 111 year: 2007 end-page: 122 ident: CR28 article-title: Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses publication-title: Immunity doi: 10.1016/j.immuni.2007.05.016 – volume: 187 start-page: 1113 year: 2011 end-page: 1119 ident: CR29 article-title: The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses publication-title: J. Immunol. doi: 10.4049/jimmunol.1100056 – volume: 281 start-page: 36443 year: 2006 end-page: 36453 ident: CR26 article-title: Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration publication-title: J. Biol. Chem. doi: 10.1074/jbc.M600788200 – volume: 2 start-page: 15 year: 2012 ident: CR32 article-title: Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer publication-title: Front. Oncol. doi: 10.3389/fonc.2012.00015 – volume: 28 start-page: 3167 year: 2010 end-page: 3175 ident: CR10 article-title: Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2009.26.7609 – volume: 21 start-page: 707 year: 2013 end-page: 717 ident: CR23 article-title: Structure and T cell inhibition properties of B7 family member, B7-H3 publication-title: Structure doi: 10.1016/j.str.2013.03.003 – volume: 27 start-page: 4006 year: 2007 end-page: 4017 ident: CR19 article-title: Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00620-06 – volume: 2 start-page: 769 year: 2001 end-page: 776 ident: CR35 article-title: The renaissance of GSK3 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/35096075 – volume: 6 start-page: 931 year: 2004 end-page: 940 ident: CR20 article-title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition publication-title: Nat. Cell Biol. doi: 10.1038/ncb1173 – volume: 523 start-page: 231 year: 2015 end-page: 235 ident: CR1 article-title: Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity publication-title: Nature doi: 10.1038/nature14404 – volume: 73 start-page: 1019 year: 2004 end-page: 1049 ident: CR12 article-title: Roles of N-linked glycans in the endoplasmic reticulum publication-title: Annual review of biochemistry doi: 10.1146/annurev.biochem.73.011303.073752 – volume: 41 start-page: 451 year: 2007 end-page: 459 ident: CR8 article-title: Scanning N-glycosylation mutagenesis of membrane proteins publication-title: Methods doi: 10.1016/j.ymeth.2006.10.002 – volume: 328 start-page: 267 year: 1987 end-page: 270 ident: CR14 article-title: A new member of the immunoglobulin superfamily--CTLA-4 publication-title: Nature doi: 10.1038/328267a0 – volume: 8 start-page: 793 year: 2002 end-page: 800 ident: CR4 article-title: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion publication-title: Nat. Med. doi: 10.1038/nm730 – volume: 359 start-page: 1 year: 2001 end-page: 16 ident: CR18 article-title: GSK3 takes centre stage more than 20 years after its discovery publication-title: Biochem. J. doi: 10.1042/bj3590001 – volume: 3 start-page: 1355 year: 2013 end-page: 1363 ident: CR34 article-title: Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-0310 – volume: 135 start-page: 2128 year: 2008 end-page: 2140 ident: CR40 article-title: Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.07.027 – volume: 363 start-page: 418 year: 1993 end-page: 423 ident: CR13 article-title: Rational design of potent sialidase-based inhibitors of influenza virus replication publication-title: Nature doi: 10.1038/363418a0 – volume: 156 start-page: 744 year: 2014 end-page: 758 ident: CR16 article-title: Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors publication-title: Cell doi: 10.1016/j.cell.2014.01.043 – volume: 497 start-page: 383 year: 2013 end-page: 387 ident: CR37 article-title: EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2 publication-title: Nature doi: 10.1038/nature12080 – volume: 11 start-page: 3887 year: 1992 end-page: 3895 ident: CR30 article-title: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death publication-title: EMBO J. doi: 10.1002/j.1460-2075.1992.tb05481.x – volume: 130 start-page: 440 year: 2007 end-page: 455 ident: CR39 article-title: IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway publication-title: Cell doi: 10.1016/j.cell.2007.05.058 – volume: 12 start-page: 252 year: 2012 end-page: 264 ident: CR7 article-title: The blockade of immune checkpoints in cancer immunotherapy publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3239 – volume: 116 start-page: 1175 year: 2003 end-page: 1186 ident: CR17 article-title: GSK-3: tricks of the trade for a multi-tasking kinase publication-title: J. Cell Sci. doi: 10.1242/jcs.00384 – volume: 574 start-page: 37 year: 2004 end-page: 41 ident: CR41 article-title: PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta publication-title: FEBS Lett. doi: 10.1016/j.febslet.2004.07.083 – volume: 21 start-page: 16 year: 2014 end-page: 37 ident: CR15 article-title: Glycotherapy: new advances inspire a reemergence of glycans in medicine publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2013.09.010 – volume: 11 start-page: 21 year: 2003 end-page: 30 ident: CR27 article-title: Crystal structure of an inactive Akt2 kinase domain publication-title: Structure doi: 10.1016/S0969-2126(02)00937-1 – volume: 3 start-page: 1 year: 2011 end-page: 13 ident: CR22 article-title: Golgi glycosylation publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a005199 – volume: 10 start-page: 138 year: 2008 end-page: 148 ident: CR31 article-title: ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation publication-title: Nat. Cell Biol. doi: 10.1038/ncb1676 – volume: 19 start-page: 1021 year: 2013 end-page: 1034 ident: CR6 article-title: Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-2063 – volume: 192 start-page: 1027 year: 2000 end-page: 1034 ident: CR2 article-title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation publication-title: J. Exp. Med. doi: 10.1084/jem.192.7.1027 – volume: 94 start-page: 107 year: 2014 end-page: 116 ident: CR5 article-title: Programmed death ligand-1 expression in non-small cell lung cancer publication-title: Lab. Invest. doi: 10.1038/labinvest.2013.130 – volume: 13 start-page: 317 year: 2011 end-page: 323 ident: CR38 article-title: p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs publication-title: Nat. Cell Biol. doi: 10.1038/ncb2173 – volume: 4 start-page: 813 year: 2003 end-page: 826 ident: CR24 article-title: Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00153-9 – volume: 4 start-page: 799 year: 2003 end-page: 812 ident: CR25 article-title: Control of meiotic and mitotic progression by the F box protein beta-Trcp1 publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00154-0 – volume: 21 start-page: 576 year: 2011 end-page: 582 ident: CR9 article-title: Mechanisms and principles of N-linked protein glycosylation publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/j.sbi.2011.08.005 – volume: 117 start-page: 225 year: 2004 end-page: 237 ident: CR36 article-title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a publication-title: Cell doi: 10.1016/S0092-8674(04)00302-2 – volume: 291 start-page: 2364 year: 2001 end-page: 2369 ident: CR11 article-title: Intracellular functions of N-linked glycans publication-title: Science doi: 10.1126/science.291.5512.2364 – volume: 13 start-page: 84 year: 2007 end-page: 88 ident: CR33 article-title: Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma publication-title: Nat. Med. doi: 10.1038/nm1517 – volume: 8 start-page: 793 year: 2002 ident: BFncomms12632_CR4 publication-title: Nat. Med. doi: 10.1038/nm730 – volume: 156 start-page: 744 year: 2014 ident: BFncomms12632_CR16 publication-title: Cell doi: 10.1016/j.cell.2014.01.043 – volume: 117 start-page: 225 year: 2004 ident: BFncomms12632_CR36 publication-title: Cell doi: 10.1016/S0092-8674(04)00302-2 – volume: 41 start-page: 451 year: 2007 ident: BFncomms12632_CR8 publication-title: Methods doi: 10.1016/j.ymeth.2006.10.002 – volume: 3 start-page: 1 year: 2011 ident: BFncomms12632_CR22 publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a005199 – volume: 11 start-page: 21 year: 2003 ident: BFncomms12632_CR27 publication-title: Structure doi: 10.1016/S0969-2126(02)00937-1 – volume: 28 start-page: 3167 year: 2010 ident: BFncomms12632_CR10 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2009.26.7609 – volume: 10 start-page: 138 year: 2008 ident: BFncomms12632_CR31 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1676 – volume: 11 start-page: 3887 year: 1992 ident: BFncomms12632_CR30 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1992.tb05481.x – volume: 574 start-page: 37 year: 2004 ident: BFncomms12632_CR41 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2004.07.083 – volume: 281 start-page: 36443 year: 2006 ident: BFncomms12632_CR26 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M600788200 – volume: 13 start-page: 317 year: 2011 ident: BFncomms12632_CR38 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2173 – volume: 4 start-page: 813 year: 2003 ident: BFncomms12632_CR24 publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00153-9 – volume: 2 start-page: 769 year: 2001 ident: BFncomms12632_CR35 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/35096075 – volume: 21 start-page: 576 year: 2011 ident: BFncomms12632_CR9 publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/j.sbi.2011.08.005 – volume: 192 start-page: 1027 year: 2000 ident: BFncomms12632_CR2 publication-title: J. Exp. Med. doi: 10.1084/jem.192.7.1027 – volume: 4 start-page: 799 year: 2003 ident: BFncomms12632_CR25 publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00154-0 – volume: 21 start-page: 16 year: 2014 ident: BFncomms12632_CR15 publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2013.09.010 – volume: 6 start-page: 931 year: 2004 ident: BFncomms12632_CR20 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1173 – volume: 187 start-page: 1113 year: 2011 ident: BFncomms12632_CR29 publication-title: J. Immunol. doi: 10.4049/jimmunol.1100056 – volume: 291 start-page: 2364 year: 2001 ident: BFncomms12632_CR11 publication-title: Science doi: 10.1126/science.291.5512.2364 – volume: 328 start-page: 267 year: 1987 ident: BFncomms12632_CR14 publication-title: Nature doi: 10.1038/328267a0 – volume: 116 start-page: 1175 year: 2003 ident: BFncomms12632_CR17 publication-title: J. Cell Sci. doi: 10.1242/jcs.00384 – volume: 17 start-page: 9 year: 2009 ident: BFncomms12632_CR21 publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.06.016 – volume: 94 start-page: 107 year: 2014 ident: BFncomms12632_CR5 publication-title: Lab. Invest. doi: 10.1038/labinvest.2013.130 – volume: 19 start-page: 1021 year: 2013 ident: BFncomms12632_CR6 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-2063 – volume: 73 start-page: 1019 year: 2004 ident: BFncomms12632_CR12 publication-title: Annual review of biochemistry doi: 10.1146/annurev.biochem.73.011303.073752 – volume: 76 start-page: 1451 year: 2016 ident: BFncomms12632_CR42 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-1941 – volume: 523 start-page: 231 year: 2015 ident: BFncomms12632_CR1 publication-title: Nature doi: 10.1038/nature14404 – volume: 130 start-page: 440 year: 2007 ident: BFncomms12632_CR39 publication-title: Cell doi: 10.1016/j.cell.2007.05.058 – volume: 363 start-page: 711 year: 2010 ident: BFncomms12632_CR3 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1003466 – volume: 2 start-page: 15 year: 2012 ident: BFncomms12632_CR32 publication-title: Front. Oncol. doi: 10.3389/fonc.2012.00015 – volume: 21 start-page: 707 year: 2013 ident: BFncomms12632_CR23 publication-title: Structure doi: 10.1016/j.str.2013.03.003 – volume: 12 start-page: 252 year: 2012 ident: BFncomms12632_CR7 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3239 – volume: 363 start-page: 418 year: 1993 ident: BFncomms12632_CR13 publication-title: Nature doi: 10.1038/363418a0 – volume: 359 start-page: 1 year: 2001 ident: BFncomms12632_CR18 publication-title: Biochem. J. doi: 10.1042/bj3590001 – volume: 3 start-page: 1355 year: 2013 ident: BFncomms12632_CR34 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-0310 – volume: 497 start-page: 383 year: 2013 ident: BFncomms12632_CR37 publication-title: Nature doi: 10.1038/nature12080 – volume: 135 start-page: 2128 year: 2008 ident: BFncomms12632_CR40 publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.07.027 – volume: 13 start-page: 84 year: 2007 ident: BFncomms12632_CR33 publication-title: Nat. Med. doi: 10.1038/nm1517 – volume: 27 start-page: 4006 year: 2007 ident: BFncomms12632_CR19 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00620-06 – volume: 27 start-page: 111 year: 2007 ident: BFncomms12632_CR28 publication-title: Immunity doi: 10.1016/j.immuni.2007.05.016 |
| SSID | ssj0000391844 |
| Score | 2.6651487 |
| Snippet | Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here... Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 12632 |
| SubjectTerms | 13/106 14/1 38/70 631/250/580 631/67/1059/2325 631/67/1347 631/80/458/1524 64 64/60 82/58 Animal models Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis B7-H1 Antigen - immunology B7-H1 Antigen - metabolism beta-Transducin Repeat-Containing Proteins - metabolism Breast - pathology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - pathology Cancer Cell death Cell Line, Tumor Deactivation Epidermal growth factor Epidermal Growth Factor - metabolism Female Gefitinib Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - metabolism Glycosylation Growth factors Humanities and Social Sciences Humans Immunity Immunologic Surveillance - immunology Immunosuppression Inactivation Kinases Ligands Lymphocyte Activation - immunology Lymphocytes T Mice Mice, Inbred BALB C Mortality multidisciplinary PD-1 protein PD-L1 protein Phosphorylation Programmed Cell Death 1 Receptor - metabolism Proteasomes Protein Stability - drug effects Proteins Quinazolines - pharmacology Quinazolines - therapeutic use Science Science (multidisciplinary) Signal transduction T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Escape - immunology Tumors Ubiquitination Xenograft Model Antitumor Assays |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEB1CoJBLaZq0dZMGFZJLQcSOJMs6tqVpCDSnhORm9NkGtt5Q7x7233dG9i67TSCX-mgNWMyMNG-s0RuAY7Sy93VjuWuU59JZyRvjDU8ungmECyoJuu_846q-uJGXd-purdUX1YQN9MCD4k6NcvRgIhO0TMaaoJWPBrfU4EqfMjTCmLeWTOU9WBhMXeR4Ia8UzWmHBvzdV0RPvhGCMlP_U_DycZXkP0elOQKdv4KXI3Rkn4cp78JW7F7Di6GZ5GIPbr9PFn7aL4biNma7wBD5Ue3rcNOSTRMbq7HwcywQ9mOT-58oyCvWzx9ySWzs2TWnv_mMbjxQY4l9uDn_dv31go9tE7jH6D3jyiEoapKMpilT8MGiLqqEUIO44jE8l0kYq1UQoiYufSGDEt5VTgWHy9dZ8Qa2u2kX3wFzGO6t04EsLUunbKx1lTDpqqJNTVIFfFpqsvUjpzi1tpi0-WxbNO2a2gs4Xgk_DFQaT4t9IZOsRIj_Or9Ar2hHr2if84oCDpcGbcdF2bcIZqQRQhtdwMfVMC4n0qrt4nSeZYiSDZPYAt4O9l_N5EwrjWgVR_SGZ2xMdXOku_-VKbsVUeOVsoCTpQ-tTeuxDt7_Dx0cwA6iuzr_AC8PYXv2Zx4_IIKauaO8WP4CphsfRQ priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkLojwDbWWkckGymtR2HJ8QINoKCU6t2FvkZ6m0JEuze9h_z4zjDV1akeN6tLFmPJnP4_E3hByClZ2rG8NsIx0T1gjWaKdZtOGYA1yQkeN952_f67ML8XUmZznhNuSyys03MX2ofe8wR34EkUjA5ltp9WHxm2HXKDxdzS007pMHSF2GJV1qpqYcC7KfN0Lka3klb446-MtfQ4Uk5VuBKPH13wUyb9dK_nNgmuLQyRPyOANI-nG0-C65F7qn5OHYUnL9jPw4na9dP6zHEjdqOk8B_2EF7HjfkvaR5poseB31iADp_OoSBFlFh9UiFcaGgZ4zzOlTvPeA7SWek4uTL-efz1hunsAcxPAlkxagURNF0E0ZvfMGdFFFABzIGA9BuoxcGyU95zUy6nPhJXe2stJbcGJr-Auy0_VdeEWohaBvrPJob1FaaUKtqghbryqY2ERZkPcbTbYuM4tjg4t5m064edPeUHtBDifhxUiocbfYJzTJJIIs2OmH_vqyzU7VamnxgU2uVyJqo72SLmgIt96WLpqC7G0M2mbXHNq_C6kgb6dhcCrUqulCv0oySMwGW9mCvBztP83kWEkFmBVG1NbK2Jrq9kh39TMRd0skyCtFQd5t1tCNad3Wwev_T_8NeQTorU4J7nKP7CyvV2EfENLSHiQ3-AOHRBUo priority: 102 providerName: ProQuest – databaseName: SpringerOpen Free (Free internet resource, activated by CARLI) dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagCIkLassrtEVGKhekiKS2Y_sIK0pVCU6t6C3ys1TaJlWze9h_z4zjjXZpD-SWeKJYM-PMZ3v8DSHHYGXnGmVKq4QruTW8VNrpMtpwwgAuiMjwvPPPX83ZJT-_EleZZ3vIaZUjpWX6Ta-zw750cHc71Mgu_pQ8Q852dOdZM5sWVJDqXHGez-BVTG2-sxV1Ejn_Y4jyYWLkP7ujKeic7pKXGS3Sr2P_9siT0O2T52P9yNUr8vvHfOX6YTXms1HTeQpgD9Ndx8OVtI80J2DB56hHuEfnN9cgWNZ0WN6lLNgw0IsSF_ApHnLAWhKvyeXp94vZWZkrJZQOAvaiFBZwkIo8aFVF77wBXdQR0AXSw0NEriLTRgrPWIP0-Yx7wZytrfAWRqw17A3Z6fouvCPUQoQ3Vno0Lq-sMKGRdYR5Vh1MVFEU5PNak63LNOJYzWLepu1sptoNtRfkeBK-G9kzHhf7hiaZRJDyOj3o76_b7AKtFhYvmNF6yaM22kvhgobY6m3loinI4dqgbR6HQwv4hWvGpJYF-Tg1wwhCrZou9MskgyxsMG8tyNvR_lNPTqSQAFChRW55xlZXt1u6mz-JpVsgG17FC_Jp7UMb3Xqog_f_KXdAXgBma9KydnVIdhb3y3AEuGhhP6Tx8Bc0MBGy priority: 102 providerName: Springer Nature |
| Title | Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity |
| URI | https://link.springer.com/article/10.1038/ncomms12632 https://www.ncbi.nlm.nih.gov/pubmed/27572267 https://www.proquest.com/docview/1814933797 https://www.proquest.com/docview/1815681917 https://pubmed.ncbi.nlm.nih.gov/PMC5013604 https://doaj.org/article/95bbbbb825d74f9a9d75ce9718db0cfa |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEB7yoNBL6LtqU7OF9FJQK3W1Wu2hFMfECYaE0sbUN7HPNOBKiR9Q__vOriQTJz7VBxmkFVrmoflmNfsNwBFqWeu8kLEqmI4zJbO4EFrETtkvFOECc9Tvdz6_yM_G2WjCJjvQNeNsBTjfmtr5flLj2fTT39vVN3T4r82W8eJzhbr5M0898_gu7GNI4t5Dz1ucH17JVGAmk7X78-7d4_mAOeOIQ_hGcAoc_tuA58P6yXsfUUNsGj6BgxZUkn5jBU9hx1bP4FHTZnL1HH6dTle6nq-asjciK0MQE_qq2GYPJqkdaeu08HHEeFRIptdXODBOyXx5E4pl7Zxcxn6dn_i9EL7lxAsYD08uB2dx21Ah1hjXFzFTCJcKl1lRJM5oI1EsqUMQ4lnkMXAnjgrJmaE09yz7NDOMapUqZhQ6tpL0JexVdWVfA1EIBKTixttAligmbc5Th-lYaqUrHIvgYyfJUrds477pxbQMX71pUd7RQARH68E3DcnG9mHHXiXrIZ4ZO5yoZ1dl62ilYMr_MPE1PHNCCsOZtgJDsFGJdjKCw06hZWdtJcKcTFDKBY_g_foyOpqXqqxsvQxjPFkbprcRvGr0v55JZz8R8A3L2Jjq5pXq-ncg82aeNC_JIvjQ2dCdaT2UwZv_fsJbeIxgLw_r4ckh7C1mS_sOAdVC9WCXTzgei-FpD_b7_dHPEf4fn1x8_4FnB_mgF5YqesGp_gGnfiwE |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9NAFH4qRQguiLW4FBik9oJk1cnMZOwDQmwlpcspFbmZWUulYKd1IpQ_xW_kPS-hoRW3-ph5isdvmffNzFsAtlHK1g5SHZtU2lgYLeI0s1kcjO9zhAsycMp3PjoeDE_E17Ecr8HvLheGwiq7NbFeqF1p6Yx8Fz2RwM23ytS76XlMXaPodrVrodGoxYFf_MItW_V2_xPKd6ff3_s8-jiM264CsUXnNoulQcyQBuGzNAnOOs3R3gN6Yiqljt4rCTzTSjrOB1RqngsnuTU9I51B7Taa4__egtvoeBOyKDVWyzMdqraeCtGmASY83S3wE35WPSqKvuL46v4A14Haq7GZ_1zQ1n5v7wHcbwEre99o2ENY88UjuNO0sFw8hm9fJgtbVosmpI7pwjHEmxRx2-R3sjKwNgYMX8ccIU42OTtFwrjHqvm0DsT1FRvFdIfAKM-C2lk8gZMbYetTWC_Kwj8DZhBkaKMc6ZdIjNR-oHoBt3o9r0MaZARvOk7mtq1kTg01Jnl9o87T_BLbI9heEk-bAh7Xk30gkSxJqOp2_UN5cZq3Rpxn0tCDm2qnRMh05pS0PkP37kxig45gqxNo3i4FVf5XcSN4vRxGIyau6sKX85qGCsHh1jmCjUb-y5n0lVSIkXFErWjGylRXR4qzH3WhcEkF-RIRwU6nQ5emdZUHm_-f_iu4OxwdHeaH-8cHz-EeIsdBfbiebMH67GLuXyA6m5mXtUkw-H7TNvgHOPBQTw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VIhAXxBtDgUVqL0hW7exu1j4gBJTQUqg4tCI3d5-lUrBDnQjlr_HrmPEjNLTiVh-zo3g9j51vd-cBsIlStnaY6dhk0sbCaBFnuc3jYPyAI1yQgVO-85eD4e6R-DSW4zX43efCUFhlvyY2C7WrLJ2Rb6MnErj5VrnaDl1YxNed0Zvpz5g6SNFNa99Oo1WRfb_4hdu3-vXeDsp6azAYfTh8vxt3HQZii45uFkuD-CELwudZEpx1mqPtB_TKVFYdPVkSeK6VdJwPqew8F05ya1IjnUFNN5rj_16D64rLlGxMjdXyfIcqr2dCdCmBCc-2S_ycH3VKBdJXnGDTK-AygHsxTvOfy9rGB47uwO0OvLK3rbbdhTVf3oMbbTvLxX349nGysFW9aMPrmC4dQ-xJ0bdtrierAuviwfB1zBH6ZJPTEySMU1bPp01Qrq_ZYUz3CYxyLqi1xQM4uhK2PoT1sir9Y2AGAYc2ypGuicRI7YcqDbjtS70OWZARvOo5Wdiuqjk115gUze06z4pzbI9gc0k8bYt5XE72jkSyJKEK3M0P1dlJ0Rl0kUtDD26wnRIh17lT0vocXb0ziQ06go1eoEW3LNTFXyWO4OVyGA2auKpLX80bGioKh9voCB618l_OZKCkQryMI2pFM1amujpSnn5vioZLKs6XiAi2eh06N62LPHjy_-m_gJtofcXnvYP9p3ALQeSwOWdPNmB9djb3zxCozczzxiIYHF-1Cf4BqytUhQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Glycosylation+and+stabilization+of+programmed+death+ligand-1+suppresses+T-cell+activity&rft.jtitle=Nature+communications&rft.au=Li%2C+Chia-Wei&rft.au=Lim%2C+Seung-Oe&rft.au=Xia%2C+Weiya&rft.au=Lee%2C+Heng-Huan&rft.date=2016-08-30&rft.pub=Nature+Publishing+Group&rft.eissn=2041-1723&rft.volume=7&rft_id=info:doi/10.1038%2Fncomms12632&rft_id=info%3Apmid%2F27572267&rft.externalDocID=PMC5013604 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |