Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses

• Published in: Science (American Association for the Advancement of Science) Vol. 342; no. 6155; pp. 243 - 247
• Main Authors: Shi, Yi, Zhang, Wei, Wang, Fei, Qi, Jianxun, Wu, Ying, Song, Hao, Gao, Feng, Bi, Yuhai, Zhang, Yanfang, Fan, Zheng, Qin, Chengfeng, Sun, Honglei, Liu, Jinhua, Haywood, Joel, Liu, Wenjun, Gong, Weimin, Wang, Dayan, Shu, Yuelong, Wang, Yu, Yan, Jinghua, Gao, George F.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 11.10.2013; The American Association for the Advancement of Science
• Subjects: Affinity; amino acid sequences; Amino acids; Animals; Avian flu; avian influenza; Binding; binding sites; Birds; China; Crystallography, X-Ray; Glycine - chemistry; Glycine - genetics; Glycine - metabolism; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; hemagglutinins; Human; human diseases; Humans; hydrophobicity; Hydroxyapatite; Influenza; Influenza A virus; Influenza A virus - metabolism; Influenza in Birds - virology; Influenza, Human - virology; mutants; mutation; polysaccharides; Protein Conformation; Receptors; Receptors, Cell Surface - chemistry; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; virion; Virology; Viruses; China

An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln²²⁶) and A/Anhui/1/2013 (AH-H7N9) (co...