Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart

• Published in: Scientific reports Vol. 13; no. 1; pp. 15022 - 14
• Main Authors: Del Gaudio, Francesca, Liu, Dongli, Andaloussi Mäe, Maarja, Braune, Eike-Benjamin, Hansson, Emil M, Wang, Qing-Dong, Betsholtz, Christer, Lendahl, Urban
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 12.09.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Cardiomyocytes; CD36 antigen; Cytology; Fibrosis; Heart; Hypertrophy; Medicin och hälsovetenskap; Metabolism; Oxygenation; Pericytes; Smooth muscle; Ventricle

Abstract The heart depends on a functional vasculature for oxygenation and transport of nutrients, and it is of interest to learn how primary impairment of the vasculature can indirectly affect cardiac function and heart morphology. Notch3 -deficiency causes vascular smooth muscle cell (VSMC) loss i...