Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology

Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation scientist....

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Published inAAPS PharmSciTech Vol. 21; no. 8; p. 309
Main Authors Nair, Athira R., Lakshman, Yarlagadda Dani, Anand, Vullendula Sai Krishna, Sree, K. S. Navya, Bhat, Krishnamurthy, Dengale, Swapnil J.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 08.11.2020
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Crystallization
Drug Carriers - chemistry
Pharmacology/Toxicology
Pharmacy
Polymers - chemistry
Review
Review Article
Solubility
solubility
polymers
solid dispersion
stability
dissolution
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Abstract Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation scientist. Since the advent of the solid dispersion technology in the early 1960s, there have been more than 5000 scientific papers published in the subject area. This review discusses the polymeric carrier properties of most extensively used polymers PVP, Copovidone, PEG, HPMC, HPMCAS, and Soluplus® in the solid dispersion technology. The literature trends about preparation techniques, dissolution, and stability improvement are analyzed from the Scopus® database to enable a formulator to make an informed choice of polymeric carrier. The stability and extent of dissolution improvement are largely dependent upon the type of polymeric carrier employed to formulate solid dispersions. With the increasing acceptance of transfer dissolution setup in the research community, it is required to evaluate the crystallization/precipitation inhibition potential of polymers under dynamic pH shift conditions. Further, there is a need to develop a regulatory framework which provides definition and complete classification along with necessarily recommended studies to characterize and evaluate solid dispersions.
AbstractList Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation scientist. Since the advent of the solid dispersion technology in the early 1960s, there have been more than 5000 scientific papers published in the subject area. This review discusses the polymeric carrier properties of most extensively used polymers PVP, Copovidone, PEG, HPMC, HPMCAS, and Soluplus® in the solid dispersion technology. The literature trends about preparation techniques, dissolution, and stability improvement are analyzed from the Scopus® database to enable a formulator to make an informed choice of polymeric carrier. The stability and extent of dissolution improvement are largely dependent upon the type of polymeric carrier employed to formulate solid dispersions. With the increasing acceptance of transfer dissolution setup in the research community, it is required to evaluate the crystallization/precipitation inhibition potential of polymers under dynamic pH shift conditions. Further, there is a need to develop a regulatory framework which provides definition and complete classification along with necessarily recommended studies to characterize and evaluate solid dispersions.Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation scientist. Since the advent of the solid dispersion technology in the early 1960s, there have been more than 5000 scientific papers published in the subject area. This review discusses the polymeric carrier properties of most extensively used polymers PVP, Copovidone, PEG, HPMC, HPMCAS, and Soluplus® in the solid dispersion technology. The literature trends about preparation techniques, dissolution, and stability improvement are analyzed from the Scopus® database to enable a formulator to make an informed choice of polymeric carrier. The stability and extent of dissolution improvement are largely dependent upon the type of polymeric carrier employed to formulate solid dispersions. With the increasing acceptance of transfer dissolution setup in the research community, it is required to evaluate the crystallization/precipitation inhibition potential of polymers under dynamic pH shift conditions. Further, there is a need to develop a regulatory framework which provides definition and complete classification along with necessarily recommended studies to characterize and evaluate solid dispersions.
Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation scientist. Since the advent of the solid dispersion technology in the early 1960s, there have been more than 5000 scientific papers published in the subject area. This review discusses the polymeric carrier properties of most extensively used polymers PVP, Copovidone, PEG, HPMC, HPMCAS, and Soluplus® in the solid dispersion technology. The literature trends about preparation techniques, dissolution, and stability improvement are analyzed from the Scopus® database to enable a formulator to make an informed choice of polymeric carrier. The stability and extent of dissolution improvement are largely dependent upon the type of polymeric carrier employed to formulate solid dispersions. With the increasing acceptance of transfer dissolution setup in the research community, it is required to evaluate the crystallization/precipitation inhibition potential of polymers under dynamic pH shift conditions. Further, there is a need to develop a regulatory framework which provides definition and complete classification along with necessarily recommended studies to characterize and evaluate solid dispersions.
ArticleNumber 309
Author Anand, Vullendula Sai Krishna
Bhat, Krishnamurthy
Nair, Athira R.
Lakshman, Yarlagadda Dani
Dengale, Swapnil J.
Sree, K. S. Navya
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  surname: Nair
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– sequence: 2
  givenname: Yarlagadda Dani
  surname: Lakshman
  fullname: Lakshman, Yarlagadda Dani
  organization: Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
– sequence: 3
  givenname: Vullendula Sai Krishna
  surname: Anand
  fullname: Anand, Vullendula Sai Krishna
  organization: Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
– sequence: 4
  givenname: K. S. Navya
  surname: Sree
  fullname: Sree, K. S. Navya
  organization: Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
– sequence: 5
  givenname: Krishnamurthy
  surname: Bhat
  fullname: Bhat, Krishnamurthy
  organization: Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
– sequence: 6
  givenname: Swapnil J.
  orcidid: 0000-0002-0013-5007
  surname: Dengale
  fullname: Dengale, Swapnil J.
  email: swapnil.jd@manipal.edu
  organization: Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33161493$$D View this record in MEDLINE/PubMed
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Issue 8
Keywords solubility
polymers
solid dispersion
stability
dissolution
Language English
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Snippet Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of...
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SubjectTerms Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Crystallization
Drug Carriers - chemistry
Pharmacology/Toxicology
Pharmacy
Polymers - chemistry
Review
Review Article
Solubility
Title Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology
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https://www.ncbi.nlm.nih.gov/pubmed/33161493
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https://pubmed.ncbi.nlm.nih.gov/PMC7649155
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